1 Soluble Synthetic Combinatorial Libraries: The Use of Molecular Diversities for Drug Discovery

Chapters in this book

1. Frontmatter I
2. Introduction V
3. Contents VII
4. A Synthetic Peptide Libraries
5. 1 Soluble Synthetic Combinatorial Libraries: The Use of Molecular Diversities for Drug Discovery 1
6. 2 Combinatorial Libraries of Synthetic Structures: Synthesis, Screening, and Structure Determination 27
7. 3 Peptide Libraries Bound to Continuous Cellulose Membranes: Tools to Study Molecular Recognition 53
8. Β Nucleic Acids Libraries
9. 4 In Vitro Selection of Nucleic Acid Sequences that Bind Small Molecules 69
10. 5 Discovery and Characterization of a Thrombin Aptamer Selected from a Combinatorial ssDNA Library 87
11. C Phage Display of Peptide Libraries
12. 6 Structural and Functional Constraints in the Display of Peptides on Filamentous Phage Capsids 113
13. 7 Conformationally Defined Peptide Libraries on Phage: Selectable Templates for the Design of Pharmacological Agents 127
14. 8 Discovery of Disease-Specific Mimotopes by Screening Phage Libraries with Human Serum Samples 145
15. 9 The Utilization of Platelets and Whole Cells for the Selection of Peptides Ligands from Phage Display Libraries 159
16. 10 Identification of MHC Binding Motifs with Synthetic and Phage Displayed Peptide Libraries 175
17. D Phage Display of Protein Domains
18. 11 Isolating High Affinity Human Antibodies from Phage Repertoires 189
19. 12 Altering the Function of Enzymes and Macromolecular Inhibitors by Phage Display 205
20. Authors 223
21. Index 227
22. Backmatter 233