10 Successful examples of blockbusters drugs for drug repurposing
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Hitesh Kumar
Abstract
The development of new chemical entities or drugs is a time-taking and costly process. The unfulfilled need for the development of efficacious drugs led to a shift in the paradigm of drug repurposing against cancer. Drug repurposing means the utilization of known drugs for the treatment of new diseases. Because of the several advantages such as the lower cost, short development times, and better safety profiles that drug repurposing offers, it emerged as a hot topic and an excellent strategy for drug development in recent times. Various drugs, such as antiviral, antibiotics, antimicrobial, antibacterial, cardiovascular, non-steroidal anti-inflammatory, etc. are being explored for drug repurposing in cancer treatment. This chapter provides an overview of the repurposing of the various blockbuster drugs approved by the FDA, which exist to treat various diseases. We have summarized the repurposing of these drugs for treating various cancers. Furthermore, we have also elaborated on the possible studied mechanisms involved in demonstrating their anticancer activities.
Abstract
The development of new chemical entities or drugs is a time-taking and costly process. The unfulfilled need for the development of efficacious drugs led to a shift in the paradigm of drug repurposing against cancer. Drug repurposing means the utilization of known drugs for the treatment of new diseases. Because of the several advantages such as the lower cost, short development times, and better safety profiles that drug repurposing offers, it emerged as a hot topic and an excellent strategy for drug development in recent times. Various drugs, such as antiviral, antibiotics, antimicrobial, antibacterial, cardiovascular, non-steroidal anti-inflammatory, etc. are being explored for drug repurposing in cancer treatment. This chapter provides an overview of the repurposing of the various blockbuster drugs approved by the FDA, which exist to treat various diseases. We have summarized the repurposing of these drugs for treating various cancers. Furthermore, we have also elaborated on the possible studied mechanisms involved in demonstrating their anticancer activities.
Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
- List of authors IX
- 1 Contemporary trends in drug repurposing: Identifying new targets for existing drugs 1
- 2 Intellectual property and regulatory considerations in drug repurposing 23
- 3 Drug repurposing from an academic and industrial view 41
- 4 Implication of drug repurposing in the identification of drugs for neurological disorders 55
- 5 Implication of drug repurposing in the identification of drugs as antiviral agents 101
- 6 Implication of drug repurposing in the identification of antibacterial agents 115
- 7 The implication of drug repurposing in the identification of drugs for gastrointestinal disorders 139
- 8 Implication of drug repurposing in the identification of drugs for renal disorders 159
- 9 Drug repurposing strategy in the identification of drugs for cardiovascular disorders 181
- 10 Successful examples of blockbusters drugs for drug repurposing 207
- 11 Drug repurposing of drugs from natural and marine origins 221
- 12 Drug repurposing of selective COX-2 inhibitors in the pursuit of new therapeutic avenues 233
- 13 Advantages, opportunities, and challenges to drug repurposing 283
- Index 293
Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
- List of authors IX
- 1 Contemporary trends in drug repurposing: Identifying new targets for existing drugs 1
- 2 Intellectual property and regulatory considerations in drug repurposing 23
- 3 Drug repurposing from an academic and industrial view 41
- 4 Implication of drug repurposing in the identification of drugs for neurological disorders 55
- 5 Implication of drug repurposing in the identification of drugs as antiviral agents 101
- 6 Implication of drug repurposing in the identification of antibacterial agents 115
- 7 The implication of drug repurposing in the identification of drugs for gastrointestinal disorders 139
- 8 Implication of drug repurposing in the identification of drugs for renal disorders 159
- 9 Drug repurposing strategy in the identification of drugs for cardiovascular disorders 181
- 10 Successful examples of blockbusters drugs for drug repurposing 207
- 11 Drug repurposing of drugs from natural and marine origins 221
- 12 Drug repurposing of selective COX-2 inhibitors in the pursuit of new therapeutic avenues 233
- 13 Advantages, opportunities, and challenges to drug repurposing 283
- Index 293
