3 Drug repurposing from an academic and industrial view
-
Devendra Kumar
Abstract
Traditional drug discovery protocol may be replaced by the method of repurposing. Drug repurposing may reduce the burden of rigorous preclinical and clinical data required for traditional drug discovery. Thus, the technique will provide maximum output with minimal time and capital expense. Further, the drug repurposing method also has less risk of failure. These factors together impact the cost of the drug. The chapter includes drug repurposing in the case of neurological disorders. Moreover, drug repurposing from the industry and academic perspectives are also discussed. The tool and data bases used by these two are mentioned in the chapter. Various successful case studies adopting the method of drug repurposing are elaborated.
Abstract
Traditional drug discovery protocol may be replaced by the method of repurposing. Drug repurposing may reduce the burden of rigorous preclinical and clinical data required for traditional drug discovery. Thus, the technique will provide maximum output with minimal time and capital expense. Further, the drug repurposing method also has less risk of failure. These factors together impact the cost of the drug. The chapter includes drug repurposing in the case of neurological disorders. Moreover, drug repurposing from the industry and academic perspectives are also discussed. The tool and data bases used by these two are mentioned in the chapter. Various successful case studies adopting the method of drug repurposing are elaborated.
Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
- List of authors IX
- 1 Contemporary trends in drug repurposing: Identifying new targets for existing drugs 1
- 2 Intellectual property and regulatory considerations in drug repurposing 23
- 3 Drug repurposing from an academic and industrial view 41
- 4 Implication of drug repurposing in the identification of drugs for neurological disorders 55
- 5 Implication of drug repurposing in the identification of drugs as antiviral agents 101
- 6 Implication of drug repurposing in the identification of antibacterial agents 115
- 7 The implication of drug repurposing in the identification of drugs for gastrointestinal disorders 139
- 8 Implication of drug repurposing in the identification of drugs for renal disorders 159
- 9 Drug repurposing strategy in the identification of drugs for cardiovascular disorders 181
- 10 Successful examples of blockbusters drugs for drug repurposing 207
- 11 Drug repurposing of drugs from natural and marine origins 221
- 12 Drug repurposing of selective COX-2 inhibitors in the pursuit of new therapeutic avenues 233
- 13 Advantages, opportunities, and challenges to drug repurposing 283
- Index 293
Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
- List of authors IX
- 1 Contemporary trends in drug repurposing: Identifying new targets for existing drugs 1
- 2 Intellectual property and regulatory considerations in drug repurposing 23
- 3 Drug repurposing from an academic and industrial view 41
- 4 Implication of drug repurposing in the identification of drugs for neurological disorders 55
- 5 Implication of drug repurposing in the identification of drugs as antiviral agents 101
- 6 Implication of drug repurposing in the identification of antibacterial agents 115
- 7 The implication of drug repurposing in the identification of drugs for gastrointestinal disorders 139
- 8 Implication of drug repurposing in the identification of drugs for renal disorders 159
- 9 Drug repurposing strategy in the identification of drugs for cardiovascular disorders 181
- 10 Successful examples of blockbusters drugs for drug repurposing 207
- 11 Drug repurposing of drugs from natural and marine origins 221
- 12 Drug repurposing of selective COX-2 inhibitors in the pursuit of new therapeutic avenues 233
- 13 Advantages, opportunities, and challenges to drug repurposing 283
- Index 293
