Mass Spectrometry in Biopharmaceutical Analysis

Igor A. Kaltashov; Shunhai Wang; Guanbo Wang

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Mass Spectrometry in Biopharmaceutical Analysis

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Language: English

Published/Copyright: 2022

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About this book

Biopharmaceuticals are a unique class of compounds due to their extreme structural complexity. The current text puts together a variety of the state‐of‐the art approaches that use mass spectrometry to evaluate various aspects of biopharmaceutical products ranging from monitoring stress‐related structural changes to their quantitation in pharmacokinetic studies.

Gives an overview how mass spectrometry can be used to study biopharmaceuticals.
Explores the existing techniques, their limitations and potential pitfalls.
Contains numeorus examples of analysis of biopharmaceutical products.

Author / Editor information

Igor Kaltashov, Univ. of Massachusetts‐Amherst.
Shunhai Wang, Regeneron Pharmaceuticals.
Guanbo Wang, Peking Univ.

Topics

Publicly Available

Frontmatter
I

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Preface
V

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Contents
VII

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Chapter 1 Analytical chemistry in biopharma
1

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Chapter 2 A brief overview of biological mass spectrometry: concepts and definitions
11

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Chapter 3 Characterization of covalent structure of protein therapeutics
37

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Chapter 4 Characterization of higher order structure and protein interactions
101

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Chapter 5 Biosimilars and comparability studies
145

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Chapter 6 Characterization of impurities in biopharmaceutical products
159

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Chapter 7 Quantitation of protein therapeutics in biological samples
183

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Chapter 8 Non-protein biopharmaceuticals and related macromolecular drugs
207

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Chapter 9 What is next?
243

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Index
251

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Publishing information

Pages and Images/Illustrations in book

eBook published on:

November 22, 2021

eBook ISBN:

9783110546187

Hardcover published on:

December 6, 2021

Hardcover ISBN:

9783110544961

Pages and Images/Illustrations in book

Front matter:

10

Main content:

270

Illustrations:

26

Coloured Illustrations:

79

Tables:

2

https://doi.org/10.1515/9783110546187

eBook ISBN: 9783110546187

Hardcover ISBN: 9783110544961

Keywords for this book

Biochemical Analysis; Mass Spectroscopy; Spectroscopy; Structural Analysis

Audience(s) for this book

Biochemists, Analytical Chemists, Organic Chemists, researchers involved drug discovery and development.

Safety & product resources

Manufacturer information:: Walter de Gruyter GmbH
Genthiner Straße 13
10785 Berlin; productsafety@degruyterbrill.com

Mass Spectrometry in Biopharmaceutical Analysis

Overview

About this book

Author / Editor information

Topics

Table of contents

Frontmatter

Preface

Contents

Chapter 1 Analytical chemistry in biopharma

Chapter 2 A brief overview of biological mass spectrometry: concepts and definitions

Chapter 3 Characterization of covalent structure of protein therapeutics

Chapter 4 Characterization of higher order structure and protein interactions

Chapter 5 Biosimilars and comparability studies

Chapter 6 Characterization of impurities in biopharmaceutical products

Chapter 7 Quantitation of protein therapeutics in biological samples

Chapter 8 Non-protein biopharmaceuticals and related macromolecular drugs

Chapter 9 What is next?

Index

Bibliographic data