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5. What is the potential of SFC-MS for doping control analysis?

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Supercritical Fluid Chromatography
Ein Kapitel aus dem Buch Supercritical Fluid Chromatography

Abstract

This chapter describes the application of modern supercritical fluid chromatography (SFC), coupled with mass spectrometry (MS), for the analysis of various classes of doping agents. Even if liquid chromatography (LC) and gas chromatography (GC) remain the reference techniques for doping control analysis, SFC appears as a promising strategy for the determination of numerous doping agents owing to the recent progresses. Indeed, this chromatographic technique appears as a faster, greener, more universal, and orthogonal analytical method compared to LC-MS and GC-MS. It also offers improved sensitivity, lower matrix effects, and excellent precision when analyzing biological fluids. For all these reasons, SFC-MS is expected to be more and more widely used in doping control laboratories.

Abstract

This chapter describes the application of modern supercritical fluid chromatography (SFC), coupled with mass spectrometry (MS), for the analysis of various classes of doping agents. Even if liquid chromatography (LC) and gas chromatography (GC) remain the reference techniques for doping control analysis, SFC appears as a promising strategy for the determination of numerous doping agents owing to the recent progresses. Indeed, this chromatographic technique appears as a faster, greener, more universal, and orthogonal analytical method compared to LC-MS and GC-MS. It also offers improved sensitivity, lower matrix effects, and excellent precision when analyzing biological fluids. For all these reasons, SFC-MS is expected to be more and more widely used in doping control laboratories.

Kapitel in diesem Buch

  1. Frontmatter I
  2. Preface V
  3. Contents VII
  4. List of Contributors IX
  5. 1. A history of supercritical fluid chromatography (SFC) 1
  6. 2. Achiral preparative supercritical fluid chromatography 23
  7. 3. Addressing robust operation and reproducibility in SFC 73
  8. 4. SFC within early drug discovery research – a user’s perspective 95
  9. 5. What is the potential of SFC-MS for doping control analysis? 111
  10. 6. SFC as a novel approach to assess polarity and identify intramolecular hydrogen bonding 129
  11. 7. Applications of supercritical fluid chromatography: Natural products in pharmaceutical, cosmetic, and food applications 139
  12. 8. Analytical chiral supercritical fluid chromatography 173
  13. Index 199
https://doi.org/10.1515/9783110500776-005

Kapitel in diesem Buch

  1. Frontmatter I
  2. Preface V
  3. Contents VII
  4. List of Contributors IX
  5. 1. A history of supercritical fluid chromatography (SFC) 1
  6. 2. Achiral preparative supercritical fluid chromatography 23
  7. 3. Addressing robust operation and reproducibility in SFC 73
  8. 4. SFC within early drug discovery research – a user’s perspective 95
  9. 5. What is the potential of SFC-MS for doping control analysis? 111
  10. 6. SFC as a novel approach to assess polarity and identify intramolecular hydrogen bonding 129
  11. 7. Applications of supercritical fluid chromatography: Natural products in pharmaceutical, cosmetic, and food applications 139
  12. 8. Analytical chiral supercritical fluid chromatography 173
  13. Index 199
Heruntergeladen am 9.5.2026 von https://www.degruyterbrill.com/document/doi/10.1515/9783110500776-005/html?lang=de
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