Volume 2 Complex Flavoproteins, Dehydrogenases and Physical Methods
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With contributions by:
Csaba Bajzath
, David Ballou , Elisa Bombarda , Gary Cecchini , Verónica I. Dumit , Bryan T. Eger , Holly R. Ellis , Barrie Entsch , Carlos Gomez-Moreno , Hiroshi Ishikita , Jung-Ja Kim , Goutham Kodali , Anabel Gracia Lostao , Stefania Montersino , Takeshi Nishino , Ken Okamoto , Emil F. Pai , Bernd Paulus , John M. Robbins , Reeder M. Robinson , Erik Schleicher , Anna L. Shen , Pablo Sobrado , Robert J. Stanley , Jon Stewart , Matthias Ullmann , Willem van Berkel , Adam Z. Walton , Stefan Weber , Chuanwu Xia , Jingyuan Xiong and Dongping Zhong
About this book
The dynamic field of flavin and flavoprotein biochemistry has seen rapid advancement in recent years. This comprehensive two volume set provides an overview of all aspects of contemporary research in this important class of enzymes. Topics treated include flavoproteins involved in energy generation, signal transduction and electron transfer (including respiration); oxygen activation by flavoproteins; the biology and biochemistry of complex flavoproteins; flavin and flavoprotein photochemistry/photophysics as well as biotechnological applications of flavoproteins. Recent developments in this field include new structures (including those of large membrane-integral electron transfer complexes containing FMN or FAD), elucidation of the role of flavoproteins in cell signalling pathways (including both phototaxis and the circadian cycle) and important new insights into the reaction mechanisms of flavin-containing enzymes. This volume focusing on complex flavoproteins and physical methods is an essential reference for all researchers in biochemistry, chemistry, photochemistry and photophysics working on flavoenzymes.
- Comprehensive treatment of flavoenzymes
- From basic oxidation-reduction and electron transfer chemistry and enzyme biology to modern biotechnological applications of flavoproteins
- Extensive color figures
Author / Editor information
Russ Hille, University of California, Riverside, CA, USA; Susan Miller, University of California, San Francisco, CA, USA; Bruce Palfey, University of Michigan, Ann Arbor, MI, USA.
Supplementary Materials
Topics
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Frontmatter
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Preface
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Contributing authors
vii -
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Table of contents
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1 The reaction mechanisms of Groups A and B flavoprotein monooxygenases
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2 Flavin-dependent monooxygenases in siderophore biosynthesis
29 -
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3 The flavin monooxygenases
51 -
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4 Structure and catalytic mechanism of NADPH-cytochrome P450 oxidoreductase: a prototype of the diflavin oxidoreductase family of enzymes
73 -
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5 The xanthine oxidoreductase enzyme family: xanthine dehydrogenase , xanthine oxidase , and aldehyde oxidase
103 -
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6 Assimilatory nitrate reductase
125 -
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7 Succinate dehydrogenase (Complex II) and fumarate reductase
141 -
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8 Flavoprotein disulfide reductases and structurally related flavoprotein thiol/disulfide-linked oxidoreductases
165 -
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9 Flavoenzymes in pyrimidine metabolism
203 -
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10 Excited state electronic structure of flavins and flavoproteins from theory and experiment
225 -
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11 Structural properties of the alkanesulfonate monooxygenase system that dictate function
255 -
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12 Single molecule methods to study flavoproteins
277 -
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13 Applications of Saccharomyces pastorianus Old Yellow Enzyme to asymmetric alkene reductions
299 -
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14 Contributions of protein environment to the reduction potentials of flavin-containing proteins
321 -
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15 Methods based on continuum electrostatics and their application to flavoproteins – a review
335 -
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16 Flavoproteins and blue light reception in plants
361 -
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17 Ultrafast dynamics of flavins and flavoproteins
393 -
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Index
429
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