Stem Cell-Dependent Therapies
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Edited by:
Gerhard Gross
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With contributions by:
Graca Almeida-Porada
About this book
Multipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD).
This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation.
- An important contribution to the exciting field of regenerative medicine
- Unique focus on aspects of inflammation / anti-inflammation and their implication for regeneration
- Treats bone-, tendon, cartilage and heart regeneration
- Full color illustrations
Author / Editor information
Gerhard Gross, Helmholtz Centre for Infection Research, Braunschweig, Germany; Thomas Häupl, Charité, Berlin, Germany.
Supplementary Materials
Topics
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Charles Durand and Pierre Charbord Requires Authentication Unlicensed Licensed |
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Shang Zhang, Anthony P. Hollander and David C. Wraith Requires Authentication Unlicensed Licensed |
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Alan Tyndall and Chiara Bocelli-Tyndall Requires Authentication Unlicensed Licensed |
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Andreas Kurtz and Su-Jun Oh Requires Authentication Unlicensed Licensed |
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Andrea Hoffmann, Virginia Seiffart, Sandra Laggies and Gerhard Gross Requires Authentication Unlicensed Licensed |
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Olle Ringdén and Behnam Sadeghi Requires Authentication Unlicensed Licensed |
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Behnam Sadeghi and Olle Ringdén Requires Authentication Unlicensed Licensed |
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143 |
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Christopher D. Porada and Graça Almeida-Porada Requires Authentication Unlicensed Licensed |
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Danilo Candido de Almeida, Clarice Silvia Taemi Origassa, Ênio Jose Bassi and Niels Olsen Saraiva Câmara Requires Authentication Unlicensed Licensed |
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15 Immunomodulation by mesenchymal stem cells – a potential therapeutic strategy for type 1 diabetes
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Thomas Häupl Requires Authentication Unlicensed Licensed |
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