Contents

Chapters in this book

1. Frontmatter i
2. Contents v
3. Acknowledgments xi
4. 1. Introduction 3
5. PART I. BACKGROUND
6. 2. Vertebrate Immunity 13
7. 3. Benefits of Antigenic Variation 22
8. PART II. MOLECULAR PROCESSES
9. 4. Specificity and Cross-Reactivity 33
10. 5. Generative Mechanisms 57
11. PART III. INDIVIDUAL INTERACTIONS
12. 6. Immunodominance within Hosts 73
13. 7. Parasite Escape within Hosts 93
14. PART IV. POPULATION CONSEQUENCES
15. 8. Genetic Variability of Hosts 111
16. 9. Immunological Variability of Hosts 124
17. 10. Genetic Structure of Parasite Populations 148
18. 11. Classifications by Antigenicity and Phylogeny 175
19. 12. Experimental Evolution: Foot-and-Mouth Disease Virus 188
20. 13. Experimental Evolution: Influenza 205
21. 14. Experimental Evolution: CTL Escape 230
22. 15. Measuring Selection with Population Samples 246
23. 16. Recap of Some Interesting Problems 265
24. References 269
25. Author Index 313
26. Subject Index 337