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Structure- and ligand-based drug design approaches for neglected tropical diseases

  • Rafael V. C. Guido , Glaucius Oliva and Adriano D. Andricopulo
Published/Copyright: May 22, 2012
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Pure and Applied Chemistry
From the journal Pure and Applied Chemistry Volume 84 Issue 9

Online erschienen: 2012-5-22
Erschienen im Druck: 2012-5-22

© 2013 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Preface
  2. Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry
  3. Bioactive cubitane diterpenoids from a Colombian gorgonian species of the genus Eunicea
  4. Structure- and ligand-based drug design approaches for neglected tropical diseases
  5. First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme
  6. Potent and selective 2-oxoamide inhibitors of phospholipases A2 as novel medicinal agents for the treatment of inflammatory diseases
  7. Structural and functional impairments of polysialic acid (polySia)-neural cell adhesion molecule (NCAM) synthesized by a mutated polysialyltransferase of a schizophrenic patient
  8. Balancing life with glycoconjugates: Monitoring unfolded protein response-mediated anti-angiogenic action of tunicamycin by Raman spectroscopy
  9. Exploring metal-driven stereoselectivity of glycopeptides by free-energy calculations
  10. Why are the low-energy protein normal modes evolutionarily conserved?
  11. IUPAC/CITAC Guide: Investigating out-of-specification test results of chemical composition based on metrological concepts (IUPAC Technical Report)
https://doi.org/10.1351/PAC-CON-11-11-07
Keywords for this article
biological activity; computer-aided molecular design; drug discovery; enzyme inhibitors; enzymes; ligand-based drug design; medicinal chemistry; neglected tropical diseases; structure-based drug design; structure–activity relationships

Articles in the same Issue

  1. Preface
  2. Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry
  3. Bioactive cubitane diterpenoids from a Colombian gorgonian species of the genus Eunicea
  4. Structure- and ligand-based drug design approaches for neglected tropical diseases
  5. First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme
  6. Potent and selective 2-oxoamide inhibitors of phospholipases A2 as novel medicinal agents for the treatment of inflammatory diseases
  7. Structural and functional impairments of polysialic acid (polySia)-neural cell adhesion molecule (NCAM) synthesized by a mutated polysialyltransferase of a schizophrenic patient
  8. Balancing life with glycoconjugates: Monitoring unfolded protein response-mediated anti-angiogenic action of tunicamycin by Raman spectroscopy
  9. Exploring metal-driven stereoselectivity of glycopeptides by free-energy calculations
  10. Why are the low-energy protein normal modes evolutionarily conserved?
  11. IUPAC/CITAC Guide: Investigating out-of-specification test results of chemical composition based on metrological concepts (IUPAC Technical Report)
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