Home Arsenic projects in SE Asia
Article
Licensed
Unlicensed Requires Authentication

Arsenic projects in SE Asia

  • Panida Navasumrit , Krittinee Chaisatra and Mathuros Ruchirawat EMAIL logo
Published/Copyright: March 8, 2016
Reviews on Environmental Health
From the journal Reviews on Environmental Health Volume 31 Issue 1

Abstract

Early life exposure to inorganic arsenic is associated with a wide range of malignant and chronic disease outcomes in humans. Prenatal arsenic exposure may give rise to adverse effects on child health and development as arsenic readily passes through the placenta in human beings. The impact of maternal arsenic exposure on fetal gene expression was conducted in pregnant women living in Southern Thailand. Arsenic exposed newborns had significantly higher levels of arsenic in cord blood, and a set of genes associated with numerous biological pathways, including cell signaling, apoptosis, inflammatory and stress response. A slight increase in promoter methylation of p53 in cord blood lymphocytes which correlated with arsenic accumulation in nails was observed in these exposed newborns. A follow-up study on these exposed children showed a significant increase in oxidative DNA damage, measured as 8-hydroxydeoxyguanosine (8-OHdG) in saliva. In addition, levels of urinary 8-OHdG excretion and salivary hOGG1 expression were significantly decreased in exposed children suggesting a defect in repair of 8-OHdG in arsenic-exposed children. Our study indicates that prenatal arsenic and continued exposure through early childhood can trigger various genetic and epigenetic alterations that may lead to disease development later in life.

Keywords: arsenic; hOGG1 expression; 8-hydroxydeoxyguanosine; oxidative DNA damage; prenatal exposure; promoter methylation of p53
Corresponding author: Mathuros Ruchirawat, Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Lak Si, Bangkok 10210, Thailand; Post-graduate program in Environmental Toxicology, Chulabhorn Graduate Institute, Lak Si, Bangkok, Thailand; and Center of Excellence on Environmental Health and Toxicology, CHE, Ministry of Education, Thailand, E-mail:

References

1. Hubaux R, Becker-Santos D, Enfield S, Rowbotham D, Lam S, et al. Molecular features in arsenic-induced lung tumors. Mol Cancer 2013;12:20.10.1186/1476-4598-12-20Search in Google Scholar PubMed PubMed Central

2. Merola R, Hien T, Quyen D, Vengosh A. Arsenic exposure to drinking water in the Mekong Delta. Sci Total Environ 2015;511:544–52.10.1016/j.scitotenv.2014.12.091Search in Google Scholar PubMed

3. National Toxicology Program (NTP), US Department of Health and Human Services. NTP Workshop: Role of Environmental Chemicals in the Development of Diabetes and Obesity, 2011 [accessed 2011, 1 December] Available at: http://ntp.niehs.nih.gov/go/36433.Search in Google Scholar

4. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Arsenic, metals, fibres, and dusts IARC Monogr Eval Carcinog Risks Hum. 2012, 100(PtC):11–465.Search in Google Scholar

5. Waalkes MP, Liu J, Ward JM, Diwan BA. Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in mice. Toxicol Appl Pharmacol 2004;198(3):377–84.10.1016/j.taap.2003.10.028Search in Google Scholar PubMed

6. Tokar EJ, Qu W, Waalkes MP. Arsenic, stem cells, and the developmental basis of adult cancer. Toxicol Sci 2011;120(Suppl 1):S192–203.10.1093/toxsci/kfq342Search in Google Scholar PubMed PubMed Central

7. Fry RC, Navasumrit P, Valiathan C, Svensson JP, Hogan BJ, et al. Activation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers. PLoS Genet 2007;3(11):e207.10.1371/journal.pgen.0030207Search in Google Scholar PubMed PubMed Central

8. Intarasunanont P, Navasumrit P, Waraprasit S, Chaisatra K, Suk WA, et al. Effects of arsenic exposure on DNA methylation in cord blood samples from newborn babies and in a human lymphoblast cell line. Environ Health 2012;2:11:31.10.1186/1476-069X-11-31Search in Google Scholar PubMed PubMed Central

9. Hinhumpatch P, Navasumrit P, Chaisatra K, Promvijit J, Mahidol C, et al. Oxidative DNA damage and repair in children exposed to low levels of arsenic in utero and during early childhood: application of salivary and urinary biomarkers. Toxicol Appl Pharmacol 2013;273(3):569–79.10.1016/j.taap.2013.10.002Search in Google Scholar PubMed

Received: 2015-11-16
Accepted: 2015-11-16
Published Online: 2016-03-08
Published in Print: 2016-03-01

©2016 by De Gruyter

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Traditional and emerging environmental hazards in South-East Asia: double-trouble in the 21st century
  4. A quarter century of the Pacific Basin Consortium: looking back to move forward
  5. Exposure to Metals
  6. Arsenic projects in SE Asia
  7. Lead exposure from battery recycling in Indonesia
  8. Connecting mercury science to policy: from sources to seafood
  9. Mercury exposure in the work place and human health: dental amalgam use in dentistry at dental teaching institutions and private dental clinics in selected cities of Pakistan
  10. Protecting health from metal exposures in drinking water
  11. Exposure assessment of lead from food and airborne dusts and biomonitoring in pregnant mothers, their fetus and siblings in Karachi, Pakistan and Shimotsuke, Japan
  12. Mining
  13. Reconciling PM10 analyses by different sampling methods for Iron King Mine tailings dust
  14. The “CHILD” framework for the study of artisanal mercury mining communities
  15. Hydraulic fracturing for natural gas: impact on health and environment
  16. Hazardous Waste
  17. Searching bioremediation patents through Cooperative Patent Classification (CPC)
  18. Proteomics of Sphingobium indicum B90A for a deeper understanding of hexachlorocyclohexane (HCH) bioremediation
  19. Novel industrial wastewater treatment integrated with recovery of water and salt under a zero liquid discharge concept
  20. Water
  21. Connecting science with industry: lessons learned transferring a novel plasmonic mercury sensor from the bench to the field
  22. Pilot-scale UV/H2O2 study for emerging organic contaminants decomposition
  23. Nanotechnology: a clean and sustainable technology for the degradation of pharmaceuticals present in water and wastewater
  24. Solar-driven membrane distillation demonstration in Leupp, Arizona
  25. What works in water supply and sanitation projects in developing countries with EWB-USA
  26. Natural Disasters and a Changing Environment
  27. Environmental exposures due to natural disasters
  28. Changing exposures in a changing world: models for reducing the burden of disease
  29. Sustainable development through a gendered lens: climate change adaptation and disaster risk reduction
  30. Environmental Justice and Human Rights
  31. Creating healthy and just bioregions
  32. Worm-free children: an integrated approach to reduction of soil-transmitted helminth infections in Central Java
  33. Diabetes in Native Americans: elevated risk as a result of exposure to polychlorinated biphenyls (PCBs)
  34. Pollution, health and development: the need for a new paradigm
  35. EcoSystem
  36. Pacific connections for health, ecosystems and society: new approaches to the land-water-health nexus
  37. Exposure to e-waste
  38. E-waste: the growing global problem and next steps
  39. Global challenges for e-waste management: the societal implications
  40. E-waste issues in Sri Lanka and the Basel Convention
  41. E-waste interventions in Ghana
  42. CALUX bioassay: a cost-effective rapid screening technique for screening dioxins like compounds
  43. Cancer
  44. Cancer surveillance and research on environmental contributions to cancer
  45. Domestic incense use and lung cancer in Asia: a review
  46. Children
  47. Inadequate water, sanitation and hygiene in the South Pacific: how might it be impacting children?
  48. Children’s environmental health indicators in Australia: are we collecting the right information?
  49. Community-based efforts in health promotion in indigenous villages on the Thailand-Myanmar border
  50. Emerging issues
  51. Bayesian networks in infectious disease eco-epidemiology
  52. Health co-benefits in mortality avoidance from implementation of the mass rapid transit (MRT) system in Kuala Lumpur, Malaysia
  53. Particulate matter 2.5 (PM2.5) personal exposure evaluation on mechanics and administrative officers at the motor vehicle testing center at Pulo Gadung, DKI Jakarta
  54. Life cycle assessment of dairy farms
https://doi.org/10.1515/reveh-2015-0068
Keywords for this article
arsenic; hOGG1 expression; 8-hydroxydeoxyguanosine; oxidative DNA damage; prenatal exposure; promoter methylation of p53

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Traditional and emerging environmental hazards in South-East Asia: double-trouble in the 21st century
  4. A quarter century of the Pacific Basin Consortium: looking back to move forward
  5. Exposure to Metals
  6. Arsenic projects in SE Asia
  7. Lead exposure from battery recycling in Indonesia
  8. Connecting mercury science to policy: from sources to seafood
  9. Mercury exposure in the work place and human health: dental amalgam use in dentistry at dental teaching institutions and private dental clinics in selected cities of Pakistan
  10. Protecting health from metal exposures in drinking water
  11. Exposure assessment of lead from food and airborne dusts and biomonitoring in pregnant mothers, their fetus and siblings in Karachi, Pakistan and Shimotsuke, Japan
  12. Mining
  13. Reconciling PM10 analyses by different sampling methods for Iron King Mine tailings dust
  14. The “CHILD” framework for the study of artisanal mercury mining communities
  15. Hydraulic fracturing for natural gas: impact on health and environment
  16. Hazardous Waste
  17. Searching bioremediation patents through Cooperative Patent Classification (CPC)
  18. Proteomics of Sphingobium indicum B90A for a deeper understanding of hexachlorocyclohexane (HCH) bioremediation
  19. Novel industrial wastewater treatment integrated with recovery of water and salt under a zero liquid discharge concept
  20. Water
  21. Connecting science with industry: lessons learned transferring a novel plasmonic mercury sensor from the bench to the field
  22. Pilot-scale UV/H2O2 study for emerging organic contaminants decomposition
  23. Nanotechnology: a clean and sustainable technology for the degradation of pharmaceuticals present in water and wastewater
  24. Solar-driven membrane distillation demonstration in Leupp, Arizona
  25. What works in water supply and sanitation projects in developing countries with EWB-USA
  26. Natural Disasters and a Changing Environment
  27. Environmental exposures due to natural disasters
  28. Changing exposures in a changing world: models for reducing the burden of disease
  29. Sustainable development through a gendered lens: climate change adaptation and disaster risk reduction
  30. Environmental Justice and Human Rights
  31. Creating healthy and just bioregions
  32. Worm-free children: an integrated approach to reduction of soil-transmitted helminth infections in Central Java
  33. Diabetes in Native Americans: elevated risk as a result of exposure to polychlorinated biphenyls (PCBs)
  34. Pollution, health and development: the need for a new paradigm
  35. EcoSystem
  36. Pacific connections for health, ecosystems and society: new approaches to the land-water-health nexus
  37. Exposure to e-waste
  38. E-waste: the growing global problem and next steps
  39. Global challenges for e-waste management: the societal implications
  40. E-waste issues in Sri Lanka and the Basel Convention
  41. E-waste interventions in Ghana
  42. CALUX bioassay: a cost-effective rapid screening technique for screening dioxins like compounds
  43. Cancer
  44. Cancer surveillance and research on environmental contributions to cancer
  45. Domestic incense use and lung cancer in Asia: a review
  46. Children
  47. Inadequate water, sanitation and hygiene in the South Pacific: how might it be impacting children?
  48. Children’s environmental health indicators in Australia: are we collecting the right information?
  49. Community-based efforts in health promotion in indigenous villages on the Thailand-Myanmar border
  50. Emerging issues
  51. Bayesian networks in infectious disease eco-epidemiology
  52. Health co-benefits in mortality avoidance from implementation of the mass rapid transit (MRT) system in Kuala Lumpur, Malaysia
  53. Particulate matter 2.5 (PM2.5) personal exposure evaluation on mechanics and administrative officers at the motor vehicle testing center at Pulo Gadung, DKI Jakarta
  54. Life cycle assessment of dairy farms
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2025 De Gruyter Brill
Downloaded on 6.9.2025 from https://www.degruyterbrill.com/document/doi/10.1515/reveh-2015-0068/pdf
Scroll to top button