Role of magnetic resonance diffusion weighted imaging in diagnosis of diabetic nephropathy in children living with type 1 diabetes mellitus

Eman Nabil Wahba; Ashraf Elsharkawy; Mohammad Hosny Awad; Ashraf Abdel Rahman; Amr Sarhan

doi:10.1515/jpem-2021-0379

Article

Role of magnetic resonance diffusion weighted imaging in diagnosis of diabetic nephropathy in children living with type 1 diabetes mellitus

Eman Nabil Wahba , Ashraf Elsharkawy , Mohammad Hosny Awad , Ashraf Abdel Rahman and Amr Sarhan

Published/Copyright: September 9, 2021

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From the journal Journal of Pediatric Endocrinology and Metabolism Volume 34 Issue 12

Abstract

Objectives

Diabetic nephropathy is a serious and a common complication of diabetes that can lead to end stage renal disease among children living with type 1 diabetes, thus an early and accurate method of diagnosis that allows timely intervention is of high importance. This study aimed to evaluate the role of magnetic resonance diffusion weighted imaging in diagnosis of diabetic nephropathy in children with type 1 diabetes.

Methods

This prospective, observational, case control study included 30 children with type 1 diabetes and 30 matched healthy controls attending the outpatient clinics in Mansoura University Children’s Hospital. All were subjected to magnetic resonance DWI of the renal parenchyma and their glomerular filtration rate (GFR) was estimated, along with micro albumin in 24 h urine collection and HbA1c in patients with diabetes.

Results

Children with diabetes who were positive for microalbuminuria had significantly lower apparent diffusion coefficient value compared to Children with diabetes who were negative for microalbuminuria (p = 0.034) as well as controls (p = 0.001). Among children with type 1 diabetes, apparent diffusion coefficient had significant positive correlation with estimated glomerular filtration rate (r = 0.491, p = 0.006) and negative correlation with microalbuminuria (r = −0.437, p = 0.016).

Conclusion

Magnetic resonance DWI of the renal parenchyma is correlated with estimated glomerular filtration rate (eGFR) in children with type 1 diabetes and can detect GFR deterioration even in presence of normal albumin excretion.

Keywords: diabetes mellitus type 1; diabetic nephropathies; diffusion magnetic resonance imaging; pediatrics

Corresponding author: Mohammad Hosny Awad, Department of Pediatrics, Mansoura University Children’s Hospital, Mansoura, Egypt, Phone: +20 1116966363, E-mail: mo7amed_hosny@hotmail.com

Acknowledgments

None.

Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from the parents of all individuals included in this study.
Ethical approval: The current work has been approved by the Institutional Review Board, Faculty of Medicine, Mansoura University, code: MS/17.08.93.

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Received: 2021-06-03

Accepted: 2021-08-23

Published Online: 2021-09-09

Published in Print: 2021-12-20

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Articles in the same Issue

https://doi.org/10.1515/jpem-2021-0379

Keywords for this article

diabetes mellitus type 1; diabetic nephropathies; diffusion magnetic resonance imaging; pediatrics