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Degradation of Vitamin E in Nanoemulsions during Storage as Affected by Temperature, Light and Darkness

  • Joseph Hategekimana and Fang Zhong EMAIL logo
Published/Copyright: February 11, 2015

Abstract

Vitamin E (VE) nanoemulsions confront physical instabilities and chemical degradation during processing and/or storage. Therefore, thermal stability and degradation kinetics of VE in nanoemulsions fabricated using low-energy emulsification method as a function of temperature under light and in the dark were studied. Nanoemulsions had small droplet diameter (≈110 nm). The thermal degradation of VE followed the first-order kinetics with samples heated at 75°C and above presenting the highest degradation rate and short half-life (5.22 min). The degradation of VE in long-term storage fitted the Weibull model with highest degradation in nanoemulsions stored under light at 40°C. However, VE retained in nanoemulsions after certain period of time might be boosted up when nanoemulsions are stored in the dark. Results showed that the physical stability tests alone are not enough to judge the stability of VE delivery systems, as the encapsulated VE might be lost during processing and storage.

Funding statement: Funding: This work was financially supported by National 863 Program 2011BAD23B02, 2013AA102207, NSFC 31171686, 30901000, 111 Project-B07029 and PCSIRT0627.

References

1. Brigelius-FlohéR, TraberMG. Vitamin E: function and metabolism. FASEB J1999;13:114555.10.1096/fasebj.13.10.1145Search in Google Scholar

2. MayerS, WeissJ, McClementsDJ. Vitamin E-enriched nanoemulsions formed by emulsion phase inversion: factors influencing droplet size and stability. J Colloid Interface Sci2013;15:12230.10.1016/j.jcis.2013.04.016Search in Google Scholar

3. MayerS, WeissJ, McClementsDJ. Behavior of vitamin E acetate delivery systems under simulated gastrointestinal conditions: lipid digestion and bioaccessibility of low-energy nanoemulsions. J Colloid Interface Sci2013;15:21522.10.1016/j.jcis.2013.04.048Search in Google Scholar

4. McClementsDJ, RaoJ. Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity. Crit Rev Food Sci Nutr2011;51:285330.10.1080/10408398.2011.559558Search in Google Scholar

5. McClementsDJ. Edible lipid nanoparticles: digestion, absorption, and potential toxicity. Progr Lipid Res2013;52:40923.10.1016/j.plipres.2013.04.008Search in Google Scholar

6. McClementsDJ. Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter2012;8:171929.10.1039/C2SM06903BSearch in Google Scholar

7. FernandezP, AndréV, RiegerJ, KühnleA. Nano-emulsion formation by emulsion phase inversion. Colloids Surf A2004;251:538.10.1016/j.colsurfa.2004.09.029Search in Google Scholar

8. OstertagF, WeissJ, McClementsDJ. Low-energy formation of edible nanoemulsions: factors influencing droplet size produced by emulsion phase inversion. J Colloid Interface Sci2012;388:95102.10.1016/j.jcis.2012.07.089Search in Google Scholar

9. JahanzadF, CrombieG, InnesR, SajjadiS. Catastrophic phase inversion via formation of multiple emulsions: a prerequisite for formation of fine emulsions. Chem Eng Res Des2009;87:4928.10.1016/j.cherd.2008.11.015Search in Google Scholar

10. ShinodaK, SaitoH. The stability of O/W type emulsions as functions of temperature and the HLB of emulsifiers: the emulsification by PIT-method. J Colloid Interface Sci1969;30:25863.10.1016/S0021-9797(69)80012-3Search in Google Scholar

11. YiJ, LiY, ZhongF, YokoyamaW. The physicochemical stability and in vitro bioaccessibility of beta-carotene in oil-in-water sodium caseinate emulsions. Food Hydrocolloids2014;35:1927.10.1016/j.foodhyd.2013.07.025Search in Google Scholar

12. LiangR, ShoemakerCF, YangX, ZhongF, HuangQ. Stability and bioaccessibility of β-carotene in nanoemulsions stabilized by modified starches. J Agric Food Chem2013;61:124957.10.1021/jf303967fSearch in Google Scholar

13. HuangQ, YuH, RuQ. Bioavailability and delivery of nutraceuticals using nanotechnology. J Food Sci2010;75:R507.10.1111/j.1750-3841.2009.01457.xSearch in Google Scholar

14. RaoJ, McClementsDJ. Food-grade microemulsions and nanoemulsions: role of oil phase composition on formation and stability. Food Hydrocolloids2012;29:32634.10.1016/j.foodhyd.2012.04.008Search in Google Scholar

15. AbbasS, HayatK, KarangwaE, BashariM, ZhangX. An overview of ultrasound-assisted food-grade nanoemulsions. Food Eng Rev2013;5:13957.10.1007/s12393-013-9066-3Search in Google Scholar

16. SolansC, IzquierdoP, NollaJ, AzemarN, Garcia-CelmaMJ. Nano-emulsions. Curr Opin Colloid Interface Sci2005;10:10210.10.1016/j.cocis.2005.06.004Search in Google Scholar

17. PiorkowskiDT, McClementsDJ. Beverage emulsions: recent developments in formulation, production, and applications. Food Hydrocolloids. [Internet]. [cited November 17, 2013]. Available at: http://www.sciencedirect.com/science/article/pii/S0268005X13002117Search in Google Scholar

18. SoottitantawatA, BigeardF, YoshiiH, FurutaT, OhkawaraM, LinkoP. Influence of emulsion and powder size on the stability of encapsulated d-limonene by spray drying. Innovative Food Sci Emerg Technol2005;6:10714.10.1016/j.ifset.2004.09.003Search in Google Scholar

19. JuliantoT, YuenKH, NoorAM. Improved bioavailability of vitamin E with a self emulsifying formulation. Int J Pharm2000;200:537.10.1016/S0378-5173(00)00337-9Search in Google Scholar

20. HategekimanaJ, BwengyeMK, MasambaKG, YokoyamaW, ZhongF. Formation and Stability of Vitamin E Enriched Nanoemulsions Stabilized by Octenyl Succinic Anhydride Modified Starch. ijfe. 2014;10(4):63343.10.1515/ijfe-2014-0159Search in Google Scholar

21. OzturkB, ArginS, OzilgenM, McClementsDJ. Formation and stabilization of nanoemulsion-based vitamin E delivery systems using natural surfactants: quillaja saponin and lecithin. J Food Eng2014;142:5763.10.1016/j.jfoodeng.2014.06.015Search in Google Scholar

22. SaberiAH, FangY, McClementsDJ. Fabrication of vitamin E-enriched nanoemulsions: factors affecting particle size using spontaneous emulsification. J Colloid Interface Sci2013;1:95102.10.1016/j.jcis.2012.08.069Search in Google Scholar PubMed

23. RelkinP, YungJ-M, KalninD, OllivonM. Structural behaviour of lipid droplets in protein-stabilized nano-emulsions and stability of α-tocopherol. Food Biophys2008;3:1638.10.1007/s11483-008-9064-9Search in Google Scholar

24. YangY, LeserME, SherAA, McClementsDJ. Formation and stability of emulsions using a natural small molecule surfactant: quillaja saponin (Q-naturale®). Food Hydrocolloids2013;30:58996.10.1016/j.foodhyd.2012.08.008Search in Google Scholar

25. SabliovCM, FronczekC, AsteteCE, KhachaturyanM, KhachatryanL, LeonardiC. Effects of temperature and UV light on degradation of α-tocopherol in free and dissolved form. J Am Oil Chem Soc2009;86:895902.10.1007/s11746-009-1411-6Search in Google Scholar

26. VerleyenT, Kamal-EldinA, DobarganesC, VerheR, DewettinckK, HuyghebaertA. Modeling of α-tocopherol loss and oxidation products formed during thermoxidation in triolein and tripalmitin mixtures. Lipids2001;36:71926.10.1007/s11745-001-0777-6Search in Google Scholar PubMed

27. VerleyenT, VerheR, HuyghebaertA, DewettinckK, De GreytW. Identification of α-tocopherol oxidation products in triolein at elevated temperatures. J Agric Food Chem2001;49:150811.10.1021/jf001142fSearch in Google Scholar PubMed

28. GoffmanFD, MöllersC. Changes in tocopherol and plastochromanol-8 contents in seeds and oil of oilseed rape (Brassica napus L.) during storage as influenced by temperature and air oxygen. J Agric Food Chem2000;48:16059.10.1021/jf9912755Search in Google Scholar PubMed

29. RomeroN, RobertP, MassonL, OrtizJ, PavezJ, GarridoC, et al. Effect of α-tocopherol and α-tocotrienol on the performance of Chilean hazelnut oil (Gevuina avellana Mol) at high temperature. J Sci Food Agric2004;84:9438.10.1002/jsfa.1771Search in Google Scholar

30. ShukatR, RelkinP. Lipid nanoparticles as vitamin matrix carriers in liquid food systems: on the role of high-pressure homogenisation, droplet size and adsorbed materials. Colloids Surf B2011;86:11924.10.1016/j.colsurfb.2011.03.028Search in Google Scholar PubMed

31. ShinT-S, GodberJS, MartinDE, WellsJH. Hydrolytic stability and changes in E vitamers and oryzanol of extruded rice bran during storage. J Food Sci1997;62:70428.10.1111/j.1365-2621.1997.tb15440.xSearch in Google Scholar

32. RelkinP, JungJ-M, OllivonM. Factors affecting vitamin degradation in oil-in-water nano-emulsions. J Therm Anal Calorim2009;98:1318.10.1007/s10973-009-0340-9Search in Google Scholar

33. SabliovCM, FronczekC, AsteteCE, KhachaturyanM, KhachatryanL, LeonardiC. Effects of temperature and UV light on degradation of α-tocopherol in free and dissolved form. J Am Oil Chem Soc2009;86:895902.10.1007/s11746-009-1411-6Search in Google Scholar

34. LiY, Le MauxS, XiaoH, McClementsDJ. Emulsion-based delivery systems for tributyrin, a potential colon cancer preventative agent. J Agric Food Chem2009;57:92439.10.1021/jf901836fSearch in Google Scholar

35. PreziosiV, PerazzoA, CasertaS, TomaiuoloG, GuidoS. Phase Inversion Emulsification. Chemical Engineering Transactions. 2013;32:1585–90.Search in Google Scholar

36. AntonN, VandammeTF. The universality of low-energy nano-emulsification. Int J Pharm2009;377:1427.10.1016/j.ijpharm.2009.05.014Search in Google Scholar

37. TadrosT, IzquierdoP, EsquenaJ, SolansC. Formation and stability of nano-emulsions. Adv Colloid Interface Sci2004;108–109:30318.10.1016/j.cis.2003.10.023Search in Google Scholar

38. FribergSE, CorkeryRW, BluteIA. Phase inversion temperature (PIT) emulsification process. J Chem Eng Data2011;56:428290.10.1021/je101179sSearch in Google Scholar

39. IsraelachviliJN. Special interactions: hydrogen-bonding and hydrophobic and hydrophilic interactions. Intermolecular and surface forces. 3rd ed. San Diego, CA: Academic Press, 2011:151–67. [cited April 25, 2013]. Available at: http://www.sciencedirect.com/science/article/pii/B9780123751829100089Internet10.1016/B978-0-12-375182-9.10008-9Search in Google Scholar

40. RobertP, RomeroN, OrtizJ, MassonL, Barrera-ArellanoD. Effect of Rosa mosqueta (Rosa rubiginosa) extract on the performance of Chilean hazelnut oil (Gevuina avellana Mol.) at high temperature. J Am Oil Chem Soc2006;83:6915.10.1007/s11746-006-5025-ySearch in Google Scholar

41. NissiotisM, Tasioula-MargariM. Changes in antioxidant concentration of virgin olive oil during thermal oxidation. Food Chem2002;77:3716.10.1016/S0308-8146(02)00113-9Search in Google Scholar

42. Sánchez-PazV, Pastoriza-GallegoMJ, Losada-BarreiroS, Bravo-DíazC, GunaseelanK, RomstedLS. Quantitative determination of α-tocopherol distribution in a tributyrin/brij 30/water model food emulsion. J Colloid Interface Sci2008;320:18.10.1016/j.jcis.2007.12.018Search in Google Scholar PubMed

43. SyamaladeviRM, SablaniSS, TangJ, PowersJ, SwansonBG. Stability of anthocyanins in frozen and freeze-dried raspberries during long-term storage: in relation to glass transition. J Food Sci2011;76:E41421.10.1111/j.1750-3841.2011.02249.xSearch in Google Scholar

44. RawsonA, BruntonN, TuohyM. High pressure–temperature degradation kinetics of polyacetylenes in carrots. Food Chem2012;133:1520.10.1016/j.foodchem.2011.11.123Search in Google Scholar

45. KristensenD, HansenE, ArndalA, TrinderupRA, SkibstedLH. Influence of light and temperature on the colour and oxidative stability of processed cheese. Int Dairy J2001;11:83743.10.1016/S0958-6946(01)00105-4Search in Google Scholar

46. BramleyP, ElmadfaI, KafatosA, KellyF, ManiosY, RoxboroughH, et al. Vitamin E. J Sci Food Agric2000;80:91338.10.1002/(SICI)1097-0010(20000515)80:7<913::AID-JSFA600>3.0.CO;2-3Search in Google Scholar

Published Online: 2015-2-11
Published in Print: 2015-4-1

©2015 by De Gruyter

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