Simple and efficient synthesis of novel N-dichloroacetyl-3,4-dihydro-2H-1,4-benzoxazines
-
Ying Fu
,
Li-Xia Zhao
Abstract
An easy synthetic route to N-dichloroacetyl-3,4-dihydro-2H-1,4-benzoxazine derivatives 3 involves cyclization of 2-aminophenols 1 with 1,2-dibromoethane and subsequent acylation of the resultant 3,4-dihydro-2H-1,4-benzoxazine derivatives 2 with dichloroacetyl chloride. All compounds were characterized by IR, 1H NMR, 13C NMR, ESI-MS and elemental analysis. The structure of 3a was determined by X-ray crystallographic analysis.
This work was supported by the National Nature Science Foundation of China (No. 31101473), the China Postdoctoral Science Foundation funded project (No. 2011M501006), the Science and Technology Research Project of Heilongjiang Education Department (No. 12521015, 12521002), the Research Science Foundation in Technology Innovation of Harbin (2010RFQYN108, 2012RFQXN015, 2012RFXXN002), and Northeast Agricultural University Doctor Foundation funded project.
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Articles in the same Issue
- Supplementary data
- Masthead
- Masthead
- Preliminary Communications
- Synthesis and molecular structure of (Z)-1H-purin-6-ylideneaminooxysulfonic acid: a possible secondary metabolite of adenine
- Design and synthesis of heterocyclic enamine derivatives based on skeleton of neonicotinoids
- Research Articles
- Reductive amination of 6-acetylpteridine to 6-N-arylaminoethylpteridine
- Efficient synthesis of selected phthalazine derivatives
- Synthesis of novel fluorescent 1,3,5-trisubstituted triazine derivatives and photophysical property evaluation of fluorophores and their BSA conjugates
- Fast and efficient microwave synthetic methods for some new 2(1H)-pyridone arabinosides
- Simple and efficient synthesis of novel N-dichloroacetyl-3,4-dihydro-2H-1,4-benzoxazines
- Palladium-catalyzed cascade reactions of benzyl halides with N,N-diallyl-p-toluenesulfonamide
- Iodine-catalyzed synthesis of 5-arylanthra[2,1-c][2,7]naphthyridine derivatives via three-component reaction
- One-pot synthesis of acenaphtho[1,2-b]pyrroles in the presence of supported ionic liquid catalyst
- Theoretical investigation on tautomerism and NBO analysis of 3-hydroxy-1,2,5-thiadiazole derivatives: solvent and substituent effects
