Objectives, Design and Recruitment of a Familial and Longitudinal Cohort for Studying Gene-Environment Interactions in the Field of Cardiovascular Risk: The Stanislas Cohort
-
Gérard Siest
Abstract
The main objective of the Stanislas cohort is to study the role and the contribution of genetic and environmental factors to cardiovascular status. We plan:
to describe the degree of association of a large number of cardiovascular risk indicators with cardiovascular endpoints,
to evaluate the contribution of genetic and that of environmental factors to this association,
to follow the evolution of these risk indicators during a period of at least ten years,
to search for the determinants influencing this evolution.
The principal variables studied are:
to describe the degree of association of a large number of cardiovascular risk indicators with cardiovascular endpoints,
to evaluate the contribution of genetic and that of environmental factors to this association,
to follow the evolution of these risk indicators during a period of at least ten years,
to search for the determinants influencing this evolution.
blood pressure, cardiac mass, and wall thickness of carotid and femoral arteries,
obesity and fat mass,
indicators of lipid metabolism,
genetic polymorphisms of several cardiovascular risk candidate genes,
food, tobacco and alcohol consumption,
consumption of drugs and anti-oxidant vitamins.
Between September 1993 and August 1995, 1006 families consisting of the two biological parents with at least two children were recruited totalling 4295 individuals. This cohort will be followed up until 2004. There will be two health examinations five and ten years after the initial examination. A bank of blood samples (serum and plasma) in liquid nitrogen and DNA (−80 °C) has been established.
Copyright © 1998 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Editorial
- Predictive Medicine
- Standardization and Clinical Management of Lipoprotein(a) Measurements
- Evaluation of the Iron Status of the Newborn by Soluble Transferrin Receptors in Serum
- Quantitation of IgG and IgM Human Anti-Mouse Antibodies (HAMA) Interference in CA 125 Measurements Using Affinity Chromatography
- Neopterin Plasma Concentrations Predict the Course of Severe Acute Pancreatitis
- Objectives, Design and Recruitment of a Familial and Longitudinal Cohort for Studying Gene-Environment Interactions in the Field of Cardiovascular Risk: The Stanislas Cohort
- Total Carbon Dioxide Measured by the Vitros Enzymatic Method
- Evaluation of Glucocard Memory 2 and Accutrend® Sensor Blood Glucose Meters
- Evaluation of Circulating Type I Procollagen Propeptides in Patients with Paget's Disease of Bone
- Properties and Units in the Clinical Laboratory Sciences XIII. Properties and Units in Reproduction and Fertility
- Procalcitonin as a Specific Marker of Bacterial Infection in Adults
- Biological Variation and Quantification of Health: The Emergence of the Concept of Normality
