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Cytotoxic Polyacetylenes from the Red Sea Sponge Siphonochalina siphonella
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Seif-Eldin N. Ayyad
,
Rihab Angawy
Published/Copyright:
June 2, 2014
Two new polyacetylenes, callyspongenol-D (1) and callyspongendiol (2), the known polyacetylene dehydrosiphonochalynol (3), and the known triterpenoid sipholenol-A (4) were isolated from the Red Sea sponge Siphonochalina siphonella. Their chemical structures were elucidated on the basis of spectroscopic analyses. The cytotoxicity of the isolated compounds towards the human mammary carcinoma cell line MCF-7 was determined by the lactate dehydrogenase (LDH) assay, and compounds 4 and 1 were found to be the most toxic of the four, with IC50 values of 8.8 and 11:7 mM, respectively.
Received: 2013-5-5
Revised: 2014-1-25
Published Online: 2014-6-2
Published in Print: 2014-4-1
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
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Articles in the same Issue
- A New Ergostane Triterpenoid from a Solid Culture of the Basidiomycete Inocybe lilacina
- Non-Alkaloidal Compounds from the Bulbs of the Egyptian Plant Pancratium maritimum
- In vitro Investigation of Anticancer, Cell-Cycle-Inhibitory, and Apoptosis-Inducing Effects of Diversin, a Natural Prenylated Coumarin, on Bladder Carcinoma Cells
- Antileishmanial Compounds from Moringa oleifera Lam.
- Cytotoxic Polyacetylenes from the Red Sea Sponge Siphonochalina siphonella
- The Co-Occurrence of Two Pyridine Alkaloids, Mimosine and Trigonelline, in Leucaena leucocephala
- Aqueous Garlic Extract Alleviates Liver Fibrosis and Renal Dysfunction in Bile-Duct-Ligated Rats
- The Wheat Aquaporin Gene TaAQP7 Confers Tolerance to Cold Stress in Transgenic Tobacco
- Isolation and Characterization of Wild-Type Lipoxygenase LOXPsa1 from Pleurotus sapidus
- Molecular Cloning and Characterization of a Bombyx mori Gene Encoding the Transcription Factor Atonal
- Total Antioxidant Capacity of Feces of Mammalian Herbivores and Carnivores
- Direct Asymmetric Aldol Reactions Catalyzed by Lipase from Porcine Pancreas
