Startseite Naturwissenschaften Influence of Alcohols on Micellar and Release Balances of Cationic Surfactant – Carbethopendecinium Bromide (Septonex)
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Influence of Alcohols on Micellar and Release Balances of Cationic Surfactant – Carbethopendecinium Bromide (Septonex)

  • Jarmila Oremusová , Zuzana Vitková und Petra Herdová
Veröffentlicht/Copyright: 22. Juli 2014
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Tenside Surfactants Detergents
Aus der Zeitschrift Tenside Surfactants Detergents Band 51 Heft 4

Abstract

An objective of this work is analysis of influence of selected alcohols from the group of enhancers (ethanol, propan-1-ol, propan-2-ol) and humectants (ethane-1,2-diol, propane-1,2-diol and propane-1,2,3-triol) in the hydrogels containing carbethopendecinium bromide on their associative (critical micelle concentration and thermodynamic parameters) and release properties (pH, percentage of drug release and the release rate constant). The studied hydrogels contained constant amounts of the gel-creating basis (polymer chitosan – 2.5% w/w), drug carbethopendecinium bromide (Septonex) – 1.0% w/w and additive of alcohol in 5 and 10% w/w concentrations. Associative parameter – critical micelle concentration (CMC) was evaluated by conductometric measurements. The CMC significantly increased in the environment of alcohols in comparison with water solutions as many as 50 times, while concentration of alcohols ranged within W = 0–100% mass fractions. Micellization in the both environments was spontaneous (ΔGm < 0), and from the energetic point of view it was exothermic (ΔHm < 0). The additive of alcohols in hydrogels supported the drug relase from hydrogels. As the concentration of alcohols increased the mass percentage of the drug released from gel increased as well.

Kurzfassung

Ein Ziel dieser Arbeit war, den Einfluss ausgewählter Alkohole aus der Gruppe der Enhancer (Ethanol, Propan-1-ol, Propan-2-ol) und Feuchthaltemittel (Ethan-1,2-diol, Propan-1,2-diol und Propan-1,2,3-triol) in carbethopendeciniumbromid-haltigen Hydrogelen hinsichtlich ihres assoziativen Verhaltens (d.h. kritische Mizellenbildungskonzentration und thermodynamische Parameter) und ihrer Freisetzungseigenschaften (d.h. pH, Anteil der Wirkstoffabgabe, und Geschwindigkeitskonstante der Freisetzung) zu analysieren. Die untersuchten Hydrogele enthielten konstante Mengen der gelerzeugenden Basis (2,5% Chitosan) und des Wirkstoffs (1,0% Carbethopendeciniumbromid (Septonex)) sowie Alkoholzugaben zwischen 5% und 10% (w/w). Der Assoziationsparameter (die kritische Mizellenbildungskonzentration, CMC) wurde mittels konduktometrischer Messungen bestimmt. Die CMC nimmt deutlich in Anwesenheit der Alkohole zu; im Vergleich zu wässrigen Lösungen um mehr als das 50-fache, wenn die Alko holkonzentration im Molenbruchbereich zwischen 0 und 100% liegt. Die Mizellenbildung ist sowohl in alkoholischer als auch in wässriger Umgebung spontan (ΔGm < 0) und exotherm (ΔHm < 0). Die Alkoholzugabe unterstützt die Wirkstofffreisetzung aus den Hydrogelen. Wenn die Konzentration des Alkohols ansteigt, dann steigt auch der Massenanteil des aus dem Hydrogel freigesetzten Wirkstoffs.

Key words: Carbethopendecinium bromide; (1-ethoxy-1-oxohexadecan-2-yl)-trimethylazanium bromide; alcohols; hydrogels; liberation; critical micelle concentration
Stichwörter: Carbethopendeciniumbromid; 1-(Ethoxy-1-oxohexadecan-2-yl)-trimethylazaniumbromid; Alkohole; Hydrogele; Freisetzung; kritische Mizellenbildungskonzentration
* Correspondence address Mrs. Dr Jarmila Oremusová, Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University, Odbojárov 10, 83232 Bratislava, Slovak Republic, E-Mail:

Dr. Jarmila Oremusová, PhD. graduated from the Faculty of Chemical Technology, Slovak University of Technology in Bratislava, Slovakia, in 1983. She obtained PhD degree in 1990. Since 1989 she has been acting at the Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University in Bratislava.

Assoc. Prof. Zuzana Vitková, PhD. graduated from the Faculty of Pharmacy, Comenius University in Bratislava, Slovakia, in 1967. She obtained PhD degree in 1972. Since 1993 she has been acting as associate professor at the Department of Galenic Pharmacy. Research: Modern drug delivery systems and biopharmacy. She is author of numerous journal and conference papers and two monographs related to these topics.

PharmDr. Petra Herdová PhD., graduated from the Faculty of Pharmacy, Comenius University in Bratislava, Slovakia, in 2008. She obtained PhD degree in 2011. Since 2011 she has been acting at the Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava.

References

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Received: 2013-11-03
Revised: 2014-01-09
Published Online: 2014-07-22
Published in Print: 2014-07-15

© 2014, Carl Hanser Publisher, Munich

Artikel in diesem Heft

  1. Contents/Inhalt
  2. Contents
  3. Abstracts
  4. Abstracts
  5. Application
  6. Inactivation of Human Norovirus by Common Domestic Laundry Procedures
  7. Dispersion of Bioactive Glass using Cetyltrimethylammonium Bromide
  8. Novel/“Green” Surfactants
  9. Amphiphilic Choline Carboxylates as Demulsifiers of Water-in-Crude Oil Emulsions
  10. Synthesis and Antitumor and Surface Activity of Novel Tetrachloro Metallate Complexes of Sulfaquinoxaline with Co(II), Cu(II), or Sn(II) Chlorides
  11. Micellar Chemistry
  12. Combination of Best Promoter and Micellar Catalyst for Cr(VI) Oxidation of Lactose to Lactobionic Acid in Aqueous Medium at Room Temperature
  13. Physical Chemistry
  14. Cloud Point Extraction of Polycyclic Aromatic Hydrocarbons in Aqueous Solution with Nonionic Surfactants
  15. Influence of Alcohols on Micellar and Release Balances of Cationic Surfactant – Carbethopendecinium Bromide (Septonex)
  16. Synthesis
  17. Synthesis and Characterization of Series of Soft-Template Agents for Mesoporous Materials
  18. The Role of Surface Active Agents in Sulfonation of Double Bonds
https://doi.org/10.3139/113.110316
Schlagwörter für diesen Artikel
Carbethopendecinium bromide; (1-ethoxy-1-oxohexadecan-2-yl)-trimethylazanium bromide; alcohols; hydrogels; liberation; critical micelle concentration

Artikel in diesem Heft

  1. Contents/Inhalt
  2. Contents
  3. Abstracts
  4. Abstracts
  5. Application
  6. Inactivation of Human Norovirus by Common Domestic Laundry Procedures
  7. Dispersion of Bioactive Glass using Cetyltrimethylammonium Bromide
  8. Novel/“Green” Surfactants
  9. Amphiphilic Choline Carboxylates as Demulsifiers of Water-in-Crude Oil Emulsions
  10. Synthesis and Antitumor and Surface Activity of Novel Tetrachloro Metallate Complexes of Sulfaquinoxaline with Co(II), Cu(II), or Sn(II) Chlorides
  11. Micellar Chemistry
  12. Combination of Best Promoter and Micellar Catalyst for Cr(VI) Oxidation of Lactose to Lactobionic Acid in Aqueous Medium at Room Temperature
  13. Physical Chemistry
  14. Cloud Point Extraction of Polycyclic Aromatic Hydrocarbons in Aqueous Solution with Nonionic Surfactants
  15. Influence of Alcohols on Micellar and Release Balances of Cationic Surfactant – Carbethopendecinium Bromide (Septonex)
  16. Synthesis
  17. Synthesis and Characterization of Series of Soft-Template Agents for Mesoporous Materials
  18. The Role of Surface Active Agents in Sulfonation of Double Bonds
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