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Synthesis and Antitumor and Surface Activity of Novel Tetrachloro Metallate Complexes of Sulfaquinoxaline with Co(II), Cu(II), or Sn(II) Chlorides

  • Nashwa Saleh , Manal Khowdiary and Abdel Fattah Badawi
Published/Copyright: July 22, 2014
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Tenside Surfactants Detergents
From the journal Tenside Surfactants Detergents Volume 51 Issue 4

Abstract

New sulfonamide tetrachloro metallate complexes that might possess strong carbonic anhydrase (CA) inhibitory properties were synthesized by the reaction of 4-amino-N-(quinoxalin-2-yl) benzene sulfonamide (sulfaquinoxaline) hydrochloride with different metal chlorides, i.e. CoCl2, CuCl2 or SnCl2. The produced metal complexes of the sulfonamide derivative, containing divalent cations, were characterized by standard procedures. These metal complexes might possess topical antiglaucoma properties which might make them more effective as pharmacological agents. The synthesized complexes exhibited significant cytotoxic activity against colon HCT-116 human cell line. Surface properties of these surfactants were investigated. The surface properties studies included critical micelle concentration (CMC), maximum surface excess (Γmax), minimum surface area (Amin). Free energy of micellization (ΔG°mic) and adsorption (ΔG°ads) were calculated.

Kurzfassung

Neue Sulfonamidtetra chlorometallat-Komplexe, die Carboanhydrase (CA) deutlich hemmen können, wurden in einer Reaktion des 4-Amino-N-2-quinoxalinylbenzensulfonamidhydrochlorids (= Sulfaquinoxalinhydrochlorid) mit verschiedenen Metallchloriden (CoCl2, CuCl2 oder SnCl2) synthetisiert. Die synthetisierten Metall-Komplexe der Sulfonamidderivate enthalten divalente Kationen und wurden mit Standardverfahren charakterisiert. Die Metallkomplexe könnten lokal gegen Glaukom wirken, was sie als pharmakologische Agenzien noch effektiver macht. Die synthetisierten Komplexe sind signifikant zytotoxisch aktiv gegen die humane kolorektale Karzinom-Zelllinie HCT-116. Die Oberflächeneigenschaften dieser Tenside wurden untersucht. Hierzu gehören die kritische Mizellbildungskonzentration (CMC), der maximale Oberflächenüberschuss (Γmax) und der minimale Platzbedarf an der Oberfläche (Amin). Die freien Energien der Mizellenbildung (ΔG°mic) und der Adsorption (ΔG°ads) wurden auch berechnet.

Key words: critical micelle concentration; sulfaquinoxaline tetrachlorometallate complex; carbonic anhydrase; in-vitro antitumor activity
Stichwörter: Kritische Mizellbildungskonzentration; Sulfonamid tetrachlorometallat-Komplex; Carboanhydrase; in-vitro-Antitumoraktivität
* Correspondence address Prof. Manal Mohmed Khowdiary, Elzomer St., Egyptian Petroleum Institute, Naser City, Cairo, Egypt, Tel.: 00966504348073, E-mail:

M. M. Kowdiary: She received his Ph.D. for the thesis “Synthesis and evaluation of some quaternary ammonium surfactants” from Ain Shams University in the year 2000. Now she is a Assoc. professor of Applied Organic Phiscal chemistry, petrochemicals Department, Egyptian Petroleum Research Institute. she is interested in several fields of surfactant applications, including:, emulsification, solubilization, corrosion inhibition of metals. He is also interested in the biological activity of surfactants and their metal complexes towards bacteria, fungi and tumors. Her activities now are concerned on studying the interaction of different types of surfactants with protein and macromolecules in short and long term measurements using new measurements methodology.

Dr. Nashwa Mostafa Saleh: Lecturer of Organic Chemistry, Faculty of Science, Al-Azhar University (Girl's branch). Her research interests are in the areas of both Environmental Chemistry and Medicinal Chemistry with special emphasis on antitumor agents. Her current research involves investigations on metal based drugs. Additional interests include the development of biocides and investigation of Nanotechnology for destruction of tumors.

Dr. Abdel Fattah M. Badawi is Professor of Applied Organic Chemistry in the Egyptian Petroleum Research Institute (Applied Surfactant Laboratory). He participated in the research of Applied Surfactant, Metallosurfactant Chemistry and Nanotechnology. Her research interests are in the areas of both Environmental Chemistry and Medicinal Chemistry with special emphasis on antitumor agents. His current research involves investigations on metal based drugs. Additional interests include the development of biocides and investigation of Nanotechnology for destruction of tumors.

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Received: 2013-09-05
Revised: 2014-01-30
Published Online: 2014-07-22
Published in Print: 2014-07-15

© 2014, Carl Hanser Publisher, Munich

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  2. Contents
  3. Abstracts
  4. Abstracts
  5. Application
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  8. Novel/“Green” Surfactants
  9. Amphiphilic Choline Carboxylates as Demulsifiers of Water-in-Crude Oil Emulsions
  10. Synthesis and Antitumor and Surface Activity of Novel Tetrachloro Metallate Complexes of Sulfaquinoxaline with Co(II), Cu(II), or Sn(II) Chlorides
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https://doi.org/10.3139/113.110313
Keywords for this article
critical micelle concentration; sulfaquinoxaline tetrachlorometallate complex; carbonic anhydrase; in-vitro antitumor activity

Articles in the same Issue

  1. Contents/Inhalt
  2. Contents
  3. Abstracts
  4. Abstracts
  5. Application
  6. Inactivation of Human Norovirus by Common Domestic Laundry Procedures
  7. Dispersion of Bioactive Glass using Cetyltrimethylammonium Bromide
  8. Novel/“Green” Surfactants
  9. Amphiphilic Choline Carboxylates as Demulsifiers of Water-in-Crude Oil Emulsions
  10. Synthesis and Antitumor and Surface Activity of Novel Tetrachloro Metallate Complexes of Sulfaquinoxaline with Co(II), Cu(II), or Sn(II) Chlorides
  11. Micellar Chemistry
  12. Combination of Best Promoter and Micellar Catalyst for Cr(VI) Oxidation of Lactose to Lactobionic Acid in Aqueous Medium at Room Temperature
  13. Physical Chemistry
  14. Cloud Point Extraction of Polycyclic Aromatic Hydrocarbons in Aqueous Solution with Nonionic Surfactants
  15. Influence of Alcohols on Micellar and Release Balances of Cationic Surfactant – Carbethopendecinium Bromide (Septonex)
  16. Synthesis
  17. Synthesis and Characterization of Series of Soft-Template Agents for Mesoporous Materials
  18. The Role of Surface Active Agents in Sulfonation of Double Bonds
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