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Study of Surfactant (Benzyldimethylhexadecylammonium Chloride) Effect on Selected Properties of Hydrogels

  • Petra Herdová , Zuzana Vitková und Jarmila Oremusová
Veröffentlicht/Copyright: 1. Mai 2013
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Tenside Surfactants Detergents
Aus der Zeitschrift Tenside Surfactants Detergents Band 51 Heft 1

Abstract

This paper aims to provide analysis of the influences of concentration changes of the surfactant – benzyldimethylhexadecylammonium chloride in hydrogels on their liberation, rheological, association and solubility properties. The hydrogels contained constant amounts of the gel-creating basis (polymer chitosan – 2.5 % w/w), the drug (chlorhexidine dihydrochloride – 0.1 % w/w) and the surfactant, which was used as an enhancer (0.005 – 0.05 % w/w). The highest value of the released drug corresponded to the highest surfactant concentration in the hydrogel. Critical micelle concentration and thermodynamic parameters, molar Gibbs energy, enthalpy and entropy of micellization were calculated. A linear increase of the surfactant amounts in hydrogels caused a non-linear increase of the cloud point. The appearance of the surfactant's associates in hydrogels influenced both their liberation and rheological properties.

Kurzfassung

Dieser Beitrag ist eine Analyse des Einflusses der Konzentrationsänderungen von Benzyldimethylhexadecylammoniumchlorid in Hydrogelen auf ihre Freisetzung, ihre rheologischen, assoziierenden und löslichen Eigenschaften. Die Hydrogele enthielten konstante Mengen der gel-bildenden Basis (2,5 w% Chitosan) und des Wirkstoff (0,1 w% Chlorhexidindihydrochlorid) und 0.005 – 0.05 w% Tensid, das als Verstärker eingesetzt wurde. Die höchste Menge an freigesetztem Wirkstoff stimmte mit der höchsten Tensidkonzentration im Hydrogel überein. Die kritische Mizellbildungskonzentration und die thermodynamischen Parameter (molare Gibbs-Energie, Enthalpie und Entropie der Mizellenbildung) wurden berechnet. Ein linearer Anstieg der Tensidmenge in den Hydrogelen verursachte einen nicht linearen Anstieg der Cloudpunkte. Das Auftreten von Tensidassoziaten beeinflusste sowohl die Freisetzung als auch die rheologischen Eigenschaften.

Key words: Benzyldimethyl hexadecyl ammonium chloride; chlorhexidine dihydrochloride; hydrogels; UV-VIS; viscosity; conductometry; drug release; assoziates
Stichwörter: Benzyldimethylhexadecylammoniumchlorid; Chlorhexidindihydrochlorid; Hydrogele; UV-VIS; Viskosität; Konduktometrie; Wirkstofffreisetzung; Assoziate
Correspondence address Mrs. Dr. Jarmila Oremusová, Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University, Odbojárov 10, 83232 Bratislava, Slovak Republic, Fax: +00 42 12 55 57 20 65, E-Mail:

Pharm. Dr. Petra Herdová PhD., graduated from the Faculty of Pharmacy, Comenius University in Bratislava, Slovakia, in 2008. She obtained PhD degree in 2011. Since 2011 she has been acting at the Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava.

Assoc. Prof. Zuzana Vitková, PhD. graduated from the Faculty of Pharmacy, Comenius University in Bratislava, Slovakia, in 1967. She obtained PhD degree in 1972. Since 1993 she has been acting as associate professor at the Department of Galenic Pharmacy. Research: Modern drug delivery systems and biopharmacy. She is author of numerous journal and conference papers and two monographs related to these topics.

Dr. Jarmila Oremusová, PhD. graduated from the Faculty of Chemical Technology, Slovak University of Technology in Bratislava, Slovakia, in 1983. She obtained PhD degree in 1990. Since 1989 she has been acting at the Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University in Bratislava.

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Received: 2013-03-03
Accepted: 2013-10-22
Published Online: 2013-05-01
Published in Print: 2014-01-20

© 2014, Carl Hanser Publisher, Munich

Artikel in diesem Heft

  1. Contents/Inhalt
  2. Contents
  3. Abstracts
  4. Abstracts
  5. Application
  6. Enhancing the Surface Properties of Some Amine Alginate Salts with Cationic Surfactant
  7. Method Development
  8. Transmission Measurements as Tool to Study Phase Transitions of Liquid Mixtures
  9. Novel Surfactant
  10. Synthesis and Surface Active Properties of Dimeric Gemini Sulfonate Surfactants
  11. Physical Chemistry
  12. Efficiency Boosting in Technical Grade Sugar Surfactant Based Microemulsions Using Pluronics
  13. Impact of Surfactants on the Performance of “Green Additives” as Calcium Carbonate Inhibitors for Aqueous Systems
  14. Study of Surfactant (Benzyldimethylhexadecylammonium Chloride) Effect on Selected Properties of Hydrogels
  15. Physicochemical Properties of Quaternary Ammonium Surfactants with Hydroxyethyl Groups
  16. Environmental Chemistry
  17. Removal of Basic Red 5 on Calcined Kaolinite – Characterization and Adsorption Kinetics
  18. Conference and Meeting Report
  19. Emulsions and Dispersions, Trends in Detergency, Cleaning and Hygiene, Sustainability and Product Safety, Forum for Innovations
https://doi.org/10.3139/113.110285
Schlagwörter für diesen Artikel
Benzyldimethyl hexadecyl ammonium chloride; chlorhexidine dihydrochloride; hydrogels; UV-VIS; viscosity; conductometry; drug release; assoziates

Artikel in diesem Heft

  1. Contents/Inhalt
  2. Contents
  3. Abstracts
  4. Abstracts
  5. Application
  6. Enhancing the Surface Properties of Some Amine Alginate Salts with Cationic Surfactant
  7. Method Development
  8. Transmission Measurements as Tool to Study Phase Transitions of Liquid Mixtures
  9. Novel Surfactant
  10. Synthesis and Surface Active Properties of Dimeric Gemini Sulfonate Surfactants
  11. Physical Chemistry
  12. Efficiency Boosting in Technical Grade Sugar Surfactant Based Microemulsions Using Pluronics
  13. Impact of Surfactants on the Performance of “Green Additives” as Calcium Carbonate Inhibitors for Aqueous Systems
  14. Study of Surfactant (Benzyldimethylhexadecylammonium Chloride) Effect on Selected Properties of Hydrogels
  15. Physicochemical Properties of Quaternary Ammonium Surfactants with Hydroxyethyl Groups
  16. Environmental Chemistry
  17. Removal of Basic Red 5 on Calcined Kaolinite – Characterization and Adsorption Kinetics
  18. Conference and Meeting Report
  19. Emulsions and Dispersions, Trends in Detergency, Cleaning and Hygiene, Sustainability and Product Safety, Forum for Innovations
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