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Structures of 4-{3-(X-phenyl)perhydro-1,3-oxazolo[3,4-a]pyridin-1-yl}-2,8-bis(trifluoromethyl)quinolines (X = H, 2-O2N, 3-O2N and 4-O2N), derived from mefloquine
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Raoni Raoni Gonçalves
Published/Copyright:
August 9, 2011
Abstract
The crystal structures of four 4-{3-(X-phenyl)perhydro-1,3-oxazolo[3,4-a]pyridin-1-yl}-2,8-bis(trifluoro-methyl)quinolines, (2: X = H, 2-O2N, 3-O2N and 4-O2N) are reported. Differences in the conformations of the molecules are illustrated by the angles between the best planes through the various ring moieties. There are no strong intermolecular interactions, such as O—H···O, present in any of the four compounds. Instead, present in each of the four compounds are different combinations of some of C—H···F, C—H···O(nitro), C—H···π, C—F···π, N—O···π and π···π-stacking interactions, which result in very different supramolecular arrangements.
Keywords: Mefloquine derivatives; Hydrogen bonding; Intermolecular interactions; Single crystal structure analysis; X-ray diffraction
Published Online: 2011-08-09
Published in Print: 2011-10
© by Oldenbourg Wissenschaftsverlag, Belo Horizonte, Germany
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Keywords for this article
Mefloquine derivatives;
Hydrogen bonding;
Intermolecular interactions;
Single crystal structure analysis;
X-ray diffraction
Articles in the same Issue
- Colorings of lattices based on subgroup orbits
- Structure and properties of a multi-component crystal of 2,3-dihydro-1,3-benzothiazol-2-iminium and an [MnIII4] complex salt
- Anomalous elastic and piezoelastic properties of monoclinic bis(hexylammonium) zirconium bis (nitrilotriacetate) dihydrate, (C6H13NH3)2Zr(N(CH2COO)3)2 · 2 H2O
- Crystal and molecular structures of two triphenyllead xanthates, Ph3Pb(S2COR), R = Me and i-Pr, featuring weak intramolecular Pb … O interactions
- Molecular and supramolecular structures of aromatic acetylacetonato disubstituted dihydrazones in the crystalline state
- Structures of 4-{3-(X-phenyl)perhydro-1,3-oxazolo[3,4-a]pyridin-1-yl}-2,8-bis(trifluoromethyl)quinolines (X = H, 2-O2N, 3-O2N and 4-O2N), derived from mefloquine
