An electro-amalgamation approach to produce 175Yb suitable for radiopharmaceutical applications
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Rubel Chakravarty
Abstract
175Yb is a prospective reactor produced radionuclide suitable for preparation of therapeutic radiopharmaceuticals. However, a major restraint in the use of 175Yb produced via the (n, γ) reaction, for therapeutic applications, is the presence of longer-lived 177Lu impurity which is co-produced along with 175Yb on irradiation of natural Yb2O3 target. A radiochemical separation procedure adopting electro-amalgamation approach for the removal of 177Lu impurity from 175Yb has been critically evaluated. The experimental parameters such as applied potential, electrolysis time and the pH of the electrolyte, affecting the electrochemical separation process, were studied and optimized. The developed radiochemical procedure was extensively tested for purification of up to 15 GBq of 175Yb. The purified 175Yb could be obtained in HCl medium with ∼95% yield. The 177Lu impurity could not be detected in the purified product and 175Yb was found suitable for the preparation of potential radiotherapeutic agents.
© by Oldenbourg Wissenschaftsverlag, Trombay, Mumbai-400 085, Germany
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Articles in the same Issue
- Role of an ionic liquid, 1-butyl-3-methylimidazolium 2-(2-methoxyethoxy)ethyl sulfate in extraction studies of gadolinium oxide
- Production of actinium, thorium and radium isotopes from natural thorium irradiated with protons up to 141 MeV
- Cross section measurements for gallium in the neutron energy range of 13.5 to 14.8MeV
- Syntheses and structures of two uranyl complexes with DMPU
- Incorporation of pertechnetate and perrhenate into corroded steel surfaces studied by X-ray absorption fine structure spectroscopy
- An electro-amalgamation approach to produce 175Yb suitable for radiopharmaceutical applications
- Synthesis, quality control and biological evaluation of tris[(1,10-phenanthroline)[153Sm]samarium(III)]trithiocyanate complex as a therapeutic agent
- Radiolysis of C5-BTBP in cyclohexanone irradiated in the absence and presence of an aqueous phase
