Biological studies of samarium-153 bleomycin complex in human breast cancer murine xenografts for therapeutic applications
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A. Bahrami-Samani
Abstract
In this work, a potential therapeutic DNA targeting agent, 153Sm-bleomycin complex ( 153Sm-BLM), was developed and the tumor accumulation studies were performed using single photon emission computed tomography (SPECT) and scarification studies. 153Sm-BLM was prepared at optimized conditions (room temperature, 4−8 h, 0.1 mg bleomycin for 740−3700 MBq 153SmCl3, radiochemical purity over 98%, HPLC, specific activityߙ=ߙ55 TBq/mmol). 153Sm-BLM was administered into human breast cancer murine xenografts and the biodistribution and imaging studies were performed up to 48 h. 153Sm-BLM demonstrated superior tumor accumulation properties in contrast with the other radiolabeled bleomycins with tumor: blood ratios of 41, 72 and 182 at 4, 24 and 48 h, respectively, and tumor: muscle ratios of 23, 33 and >1490 at 4, 24 and 48 h, respectively, while administered intravenously. The SPECT images also demonstrated the obvious tumor uptake at the chest region of the breast-tumor bearing mice. These initial experiments demonstrate significant accumulation of 153Sm-BLM in tumor tissues.
© by Oldenbourg Wissenschaftsverlag, München, Germany
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Articles in the same Issue
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- Biological studies of samarium-153 bleomycin complex in human breast cancer murine xenografts for therapeutic applications
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