Synthesis and biodistribution of 99mTc-Vancomycin in a model of bacterial infection
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Samina Roohi
Abstract
Vancomycin Hydrochloride is an antibiotic produced by the growth of certain strains of Streptomyces orientalis. As Vancomycin Hydrochloride is poorly absorbed after oral administration; it is given intravenously for therapy of systemic infections. Vancomycin was labeled with technetium-99m pertechnetate using SnCl2·2H2O as reducing agent. The labeling efficiency depends on ligand/reductant ratio, pH, and volume of reaction mixture. Radiochemical purity and stability of 99mTc-Vancomycin was determined by thin layer chromatography. Biodistribution studies of 99mTc-Vancomycin were performed in a model of bacterial infection in Sprague–Dawley rats. A significantly higher accumulation of 99mTc-Vancomycin was seen at sites of S. aureus infected animals. Whereas uptake of 99mTc-Vancomycin in turpentine inflamed rats were quite low.
© Oldenbourg Wissenschaftsverlag, München
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- The solubility product of NaUO2PO4·xH2O determined in phosphate and carbonate solutions
- Speciation of technetium(IV) chloride under gamma irradiation
- Synthesis and biodistribution of 99mTc-Vancomycin in a model of bacterial infection
- Prospects and problems in the production of 143Pr for radionuclide therapy applications
- Zirconium decontamination from aqueous media using lateritic minerals
Articles in the same Issue
- Theoretical investigations of the reactivity of MO4 and the electronic structure of Na2[MO4(OH)2], where M=Ru, Os, and Hs (element 108)
- Production of 234,235Np and 236Pu in bombardment of 236U with protons in the energy range from 17 to 40 MeV
- Cross-section measurements for (n, 2n) and (n, p) reactions on platinum isotopes in the neutron energy range of 13.5 to 14.6 MeV
- Sorption of U(VI) species on hydroxyapatite
- Synthesis and characterization of sodium meta-autunite, Na[UO2PO4]·3H2O
- The solubility product of NaUO2PO4·xH2O determined in phosphate and carbonate solutions
- Speciation of technetium(IV) chloride under gamma irradiation
- Synthesis and biodistribution of 99mTc-Vancomycin in a model of bacterial infection
- Prospects and problems in the production of 143Pr for radionuclide therapy applications
- Zirconium decontamination from aqueous media using lateritic minerals
