Production and radiochemical separation of rhodium-105 for radiopharmaceutical applications
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P. R. Unni
Summary
Production of no carrier added 105Rh by thermal neutron irradiation of natural Ru target and ist radiochemical separation to obtain radionuclidically and radiochemically pure species is described. Irradiation planning, post irradiation chemical separation of 105Rh from ruthenium and irridium radionuclidic contaminants are discussed in detail. 100 mg of natural Ru was irradiated in a thermal neutron flux of 3 × 1013 neutrons/cm2/s for 7 days. Irradiated target was disolved in an mixture of KIO4and KOH in presence of water. Solvent extraction with CCI4was used for removal of 97Ru and 103Ru, whereas solvent extraction with TBP was used for the removal of traces of192Ir impurity. Different radiochemical separation techniques were tested for the recovery of 105Ru and ist final purification from the accompanying radionuclidic impurities. The salts associated with the product were subsequently removed by fractional precipitation and by cation exchange chromatography. The radionuclidic purity of the 105Rh separated was estimated by gamma ray spectrometry; no radionuclidic contamination was observed. The radiochemical purity of the 105RhCI3 was acsertained bx paper chromatography and paper electrophoresis. Production of no carrier added 105Rh by thermal neutron irradiation of natural Ru target and ist radiochemical separation to obtain radionuclidically and radiochemically pure species is described. Irradiation planning, post irradiation chemical separation of 105Rh from ruthenium and irridium radionuclidic contaminants are discussed in detail. 100 mg of natural Ru was irradiated in a thermal neutron flux of 3 x 1013 neutrons / cm2/ s for 7 days. Irradiated target was disolved in an mixture of KIO4and KOH in presence of water. Solvent extraction with CCI4was used for removal of 97Ru and 103Ru, whereas solvent extraction with TBP was used for the removal of traces of192Ir impurity. Different radiochemical separation techniques were tested for the recovery of 105Ru and ist final purification from the accompanying radionuclidic impurities. The salts associated with the product were subsequently removed by fractional precipitation and by cation exchange chromatography. The radionuclidic purity of the 105Rh separated was estimated by gamma ray spectrometry; no radionuclidic contamination was observed. The radiochemical purity of the 105RhCI3 was acsertained bx paper chromatography and paper electrophoresis.
© Oldenbourg Wissenschaftsverlag, München
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Articles in the same Issue
- Excitation functions of proton induced reactions on 68Zn from threshold up to 71 MeV, with specific reference to the production of 67Cu
- X-ray absorption fine structure spectroscopy of plutonium complexes with bacillus sphaericus
- Separation of neptunium and plutonium from acidic medium using 3-phenyl-4-benzoyl-5-isoxazolone
- A statistical study of 238U and 234U/238U distributions in coral samples from the Egyptian shoreline of the north-western Red Sea and in fossil mollusk shells from the Atlantic coast of High Atlas in Morocco: Implications for 230Th/234U dating
- Ion-molecule reactions of Ru+ and Os+ with oxygen in a Penning trap
- Inner-sphere, outer-sphere and ternary surface complexes: a TRLFS study of the sorption process of Eu(III) onto smectite and kaolinite
- Radiochemical neutron activation analysis of total trace tin and determination of its differentiated compounds in aquatic biota
- Rate effected adsorption profile of selenium-thiocyanate complex onto polyurethane foam
- Production and radiochemical separation of rhodium-105 for radiopharmaceutical applications
