In-target chemistry during the production of 15O and 11C using 3He reactions
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K.A. Krohn
The use of nuclear reactions that do not involve a change in element can be advantageous for radionuclide production because enriched targets are rarely required and the yield of the nuclear reactions is usually adequate. However there is a disadvantage to these reactions for medical imaging because the product radioactivity is of low specific activity. In this report we discuss the application of radiation chemistry and nucleogenic recoil chemistry to two reactions, 16O(3He,4He)15O and 12C(3He,4He)11C, to improve specific activity of the radioactive oxygen and carbon recovered from the target. For both reactions, specific activities were improved, with minimal decrease in recovered radioactivity. For the 16O→15O reaction in water, results demonstrated that the production of [15O]-O2 followed a different reaction mechanism from that for unlabeled O2. The unlabeled yield was quantitatively predicted from classical radiation chemistry G-values for water. The radiochemical product distribution was a consequence of the combined effects of recoil chemistry and radiation chemistry. Studies with thin graphite foils demonstrated that we could irradiate sufficiently thin C foils so that a useful fraction of the recoil nucleogenic 11C atoms escaped the irradiated carbon and reacted with circulating gas to capture an appreciable fraction of the product 11C with an improvement in specific activity. Although we have shown the feasibility of producing GBq quantities of radiopharmaceuticals by recoil techniques, the advantages of even higher specific activity using enriched targets outweigh the cost of using enriched targets.
© 2015 Oldenbourg Wissenschaftsverlag GmbH, Rosenheimer Str. 145, 81671 München
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- Preface: Alfred P. Wolf Memorial Issue
- Im Memoriam Alfred P. Wolf
- The centenary of a controversial discovery: actinium
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- Possibility of production of 81Rb via the 80Kr(d,n) reaction at a small cyclotron
- Positron emission intensity in the decay of 120gI
- Production of high specific activity 27Mg by fast neutron irradiation and recoil-aided leaching
- Production of strontium-82 for the Cardiogen® PET generator: a project of the Department of Energy Virtual Isotope Center
- Lutetium-177-EDTMP for bone pain palliation. Preparation, biodistribution and pre-clinical studies
- Thermochromatographic separation of no-carrier-added 186Re or 188Re from tungsten targets relevant to nuclear medical applications
- Low energy cyclotron production and chemical separation of "no carrier added" iodine-124 from a reusable, enriched tellurium-124 dioxide/aluminum oxide solid solution target
- Physicochemical and radiochemical aspects of separation of radioiodine from TeO2-targets
- Novel separation of thallium-201 using p-tert-butylcalix[4]arene derivative
- Recovery of 201Tl by ion exchange chromatography from proton bombarded thallium cyclotron targets
- Doppler broadening as a probe of the chemical environment following oxygen-14 decay
- In-target chemistry during the production of 15O and 11C using 3He reactions
- 11C-methane production in small volume, high pressure gas targets
- 11C-methylations using 11C-methyl iodide and tetrabutylammonium fluoride
- Specific activity of [11C]CO2 generated in a N2 gas target: effect of irradiation dose, irradiation history, oxygen content and beam energy
- Effect of dissolved gas on the specific activity of N-13 labeled ions generated in water by the 16O(p,α)13N reaction
- Direct n.c.a. radioiodination of weakly activated arenes using metal salts
- Synthesis of substituted [123I]imidazo[1,2-α]pyridines as potential probes for the study of the peripheral benzodiazepine receptors using SPECT
- Determination of trace impurities in iron-based alloy using neutron activation analysis
- EXAFS analyses of technetium(I) carbonyl complexes – stability studies in solutions
- Syntheses and structures of technetium(V) and rhenium(V) oxo complexes of peptide having KYC-sequence
Articles in the same Issue
- Preface: Alfred P. Wolf Memorial Issue
- Im Memoriam Alfred P. Wolf
- The centenary of a controversial discovery: actinium
- Proton-induced nuclear reactions in neptunium-237 targets. Production of plutonium tracers in the energy range 15-40 MeV
- Possibility of production of 81Rb via the 80Kr(d,n) reaction at a small cyclotron
- Positron emission intensity in the decay of 120gI
- Production of high specific activity 27Mg by fast neutron irradiation and recoil-aided leaching
- Production of strontium-82 for the Cardiogen® PET generator: a project of the Department of Energy Virtual Isotope Center
- Lutetium-177-EDTMP for bone pain palliation. Preparation, biodistribution and pre-clinical studies
- Thermochromatographic separation of no-carrier-added 186Re or 188Re from tungsten targets relevant to nuclear medical applications
- Low energy cyclotron production and chemical separation of "no carrier added" iodine-124 from a reusable, enriched tellurium-124 dioxide/aluminum oxide solid solution target
- Physicochemical and radiochemical aspects of separation of radioiodine from TeO2-targets
- Novel separation of thallium-201 using p-tert-butylcalix[4]arene derivative
- Recovery of 201Tl by ion exchange chromatography from proton bombarded thallium cyclotron targets
- Doppler broadening as a probe of the chemical environment following oxygen-14 decay
- In-target chemistry during the production of 15O and 11C using 3He reactions
- 11C-methane production in small volume, high pressure gas targets
- 11C-methylations using 11C-methyl iodide and tetrabutylammonium fluoride
- Specific activity of [11C]CO2 generated in a N2 gas target: effect of irradiation dose, irradiation history, oxygen content and beam energy
- Effect of dissolved gas on the specific activity of N-13 labeled ions generated in water by the 16O(p,α)13N reaction
- Direct n.c.a. radioiodination of weakly activated arenes using metal salts
- Synthesis of substituted [123I]imidazo[1,2-α]pyridines as potential probes for the study of the peripheral benzodiazepine receptors using SPECT
- Determination of trace impurities in iron-based alloy using neutron activation analysis
- EXAFS analyses of technetium(I) carbonyl complexes – stability studies in solutions
- Syntheses and structures of technetium(V) and rhenium(V) oxo complexes of peptide having KYC-sequence
