Startseite Lebenswissenschaften Antidiabetic activities of aerial part of Asparagus racemosus Willd. extract: an in vitro, in vivo, and in silico approach
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Antidiabetic activities of aerial part of Asparagus racemosus Willd. extract: an in vitro, in vivo, and in silico approach

  • Priya Das , Ankrita Thapa , Suraj Mistri , Gouhar Jahan Ashraf , Sourav Sarkar , Debabrata Modak , Soumen Bhattacharjee , Ravi Kumar Singh , Tarun Kumar Dua ORCID logo , Paramita Paul , Gouranga Nandi und Ranabir Sahu ORCID logo EMAIL logo
Veröffentlicht/Copyright: 10. Februar 2025
Zeitschrift für Naturforschung C
Aus der Zeitschrift Zeitschrift für Naturforschung C Band 80 Heft 11-12

Abstract

Asparagus racemosus Willd., a significant medicinal plant in India’s Darjeeling Himalayan region. The current study aims to assess the antidiabetic efficacy of the aerial part of Asparagus racemosus Willd. utilizing a streptozotocin-nicotinamide-induced diabetic rat model. The methanolic extract of plant (ARME) was evaluated for in vitro antidiabetic activity through α-glucosidase and α-amylase enzyme suppression assay and assessed in vivo in a streptozotocin-induced rat model. A 21-day chronic multiple-dose study of ARME was examined. STZ-induced diabetic rats were treated with metformin (70 mg/kg) and ARME at concentrations of 200 and 400 mg/kg. It was discovered that ARME inhibited the activities of α-amylase and α-glucosidase and showed potent therapeutic effects on the rat’s model. ARME helps raise body weight, hemoglobin, and other blood counts and normalizes the serum parameters in the diabetic group. In addition, liver tissues’ abnormal levels of the antioxidant enzymes glutathione and lipid peroxides were returned to those of control animals. HPTLC study revealed the presence of stigmasterol, which showed a strong affinity for the proteins linked to diabetes mellitus through in silico study. As a result of these findings, ARME inhibits the activity of digestive enzymes and has antioxidant and antihyperglycemic effects in STZ-nicotinamide-induced diabetic rats.

Keywords: Asparagus racemosus Willd.; antidiabetic activity; in vitro ; in vivo ; in silico
Corresponding author: Ranabir Sahu, Department of Pharmaceutical Technology, University of North Bengal, Darjeeling, 734013, West Bengal, India, E-mail:

Funding source: University of North Bengal

Award Identifier / Grant number: 2323/R-2022

Funding source: Science and Engineering Research Board

Award Identifier / Grant number: SRG/2019/001910

Funding source: University Grants Committee

Award Identifier / Grant number: No. F. 587 30-515/2020(BSR);12/02/2020

Acknowledgments

We are grateful to the University of North Bengal for providing facilities for research.

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: The authors state no conflict of interest.

  6. Research funding: The financial support of SERB-SRG (file no. SRG/2019/001910), India, UGC-SRG [No. F. 30-515/2020(BSR);12/02/2020], India and the University assistance/support for the research project (Ref. No. 2323/R-2022), University of North Bengal, India are greatly acknowledged.

  7. Data availability: Not applicable.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/znc-2024-0142).

Received: 2024-06-13
Accepted: 2025-01-18
Published Online: 2025-02-10
Published in Print: 2025-11-25

© 2025 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review Articles
  3. Cutting-edge developments in agro-waste derived carbon nanomaterials and their multifaceted applications in agriculture: enhancing crop imaging, nutrient efficiency, and plant health
  4. Emerging silk sericin-based formulation fortified with therapeutics in the management of diabetic wound and skin tissue regeneration
  5. Biogenic selenium nanoparticles: a comprehensive update on the multifaceted application, stability, biocompatibility, risk, and opportunity
  6. Enhancing vaginal drug delivery: the nanoemulsion gel strategy
  7. Research Articles
  8. Exploring the therapeutic potential of leriodenine and nuciferine from Nelumbo nucifera for renal fibrosis: an In-silico analysis
  9. Antidiabetic activities of aerial part of Asparagus racemosus Willd. extract: an in vitro, in vivo, and in silico approach
  10. New hydrazone derivatives: synthesis, characterization, carbonic anhydrase I-II enzyme inhibition, anticancer activity and in silico studies
  11. Design and synthesis of new 1,3,4-thiadiazoles as antimicrobial and antibiofilm agents
  12. Insight the confirmation of benzothiazolidinone-derived thiadiazole scaffolds as promising antiurease and anti-Alzheimer agents: synthesis, in vitro, and in silico investigations
  13. Biotransformation of vinblastine into vincristine using a fungal endophyte Fusarium equiseti along with the assessment of its antiangiogenic properties
  14. Rapid Communications
  15. Design and synthesis of 3-(azepan-1-ylsulfonyl)-N-aryl benzamide derivatives as potent carbonic anhydrase IX inhibitors with anticancer activities
  16. Unveiling the essential oil composition and bioactivities of Piper frustratum Boerl.
https://doi.org/10.1515/znc-2024-0142
Schlagwörter für diesen Artikel
Asparagus racemosus Willd.; antidiabetic activity; in vitro; in vivo; in silico

Artikel in diesem Heft

  1. Frontmatter
  2. Review Articles
  3. Cutting-edge developments in agro-waste derived carbon nanomaterials and their multifaceted applications in agriculture: enhancing crop imaging, nutrient efficiency, and plant health
  4. Emerging silk sericin-based formulation fortified with therapeutics in the management of diabetic wound and skin tissue regeneration
  5. Biogenic selenium nanoparticles: a comprehensive update on the multifaceted application, stability, biocompatibility, risk, and opportunity
  6. Enhancing vaginal drug delivery: the nanoemulsion gel strategy
  7. Research Articles
  8. Exploring the therapeutic potential of leriodenine and nuciferine from Nelumbo nucifera for renal fibrosis: an In-silico analysis
  9. Antidiabetic activities of aerial part of Asparagus racemosus Willd. extract: an in vitro, in vivo, and in silico approach
  10. New hydrazone derivatives: synthesis, characterization, carbonic anhydrase I-II enzyme inhibition, anticancer activity and in silico studies
  11. Design and synthesis of new 1,3,4-thiadiazoles as antimicrobial and antibiofilm agents
  12. Insight the confirmation of benzothiazolidinone-derived thiadiazole scaffolds as promising antiurease and anti-Alzheimer agents: synthesis, in vitro, and in silico investigations
  13. Biotransformation of vinblastine into vincristine using a fungal endophyte Fusarium equiseti along with the assessment of its antiangiogenic properties
  14. Rapid Communications
  15. Design and synthesis of 3-(azepan-1-ylsulfonyl)-N-aryl benzamide derivatives as potent carbonic anhydrase IX inhibitors with anticancer activities
  16. Unveiling the essential oil composition and bioactivities of Piper frustratum Boerl.
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