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Unveiling the potential of chitosan-coated lipid nanoparticles in drug delivery for management of critical illness: a review

  • Ushasi Das , Devesh U. Kapoor , Sudarshan Singh ORCID logo EMAIL logo and Bhupendra G. Prajapati ORCID logo EMAIL logo
Published/Copyright: May 10, 2024
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Zeitschrift für Naturforschung C
From the journal Zeitschrift für Naturforschung C Volume 79 Issue 5-6

Abstract

Chitosan (CT), a natural, cationic, chemically stable molecule, biocompatible, biodegradable, nontoxic, polysaccharide derived from the deacetylation of chitin, has very uniquely surfaced as a material of promise for drug delivery and biomedical applications. For the oral, ocular, cutaneous, pulmonary, and nose-to-brain routes, CT-coated nanoparticles (CTCNPs) have numerous advantages, consisting of improved controlled drug release, physicochemical stability, improved cell and tissue interactions, and increased bioavailability and efficacy of the active ingredient. CTCNPs have a broad range of therapeutic properties including anticancer, antiviral, antifungal, anti-inflammatory, antibacterial properties, treating neurological disorders, and other diseases. This has led to substantial research into the many potential uses of CT as a drug delivery vehicle. CT has also been employed in a wide range of biomedical processes, including bone and cartilage tissue regeneration, ocular tissue regeneration, periodontal tissue regeneration, heart tissue regeneration, and wound healing. Additionally, CT has been used in cosmeceutical, bioimaging, immunization, and gene transfer applications. CT exhibits a number of biological activities, which are the basis for its remarkable potential for use as a drug delivery vehicle, and these activities are covered in detail in this article. The alterations applied to CT to obtain the necessary properties have been described.

Keywords: chitosan; chitin; drug delivery; chitosan-based nanoparticle; cancer
Corresponding authors: Sudarshan Singh, Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand; and Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand, E-mail: ; and Bhupendra G. Prajapati, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, Gujarat 384012, India, E-mail:
Ushasi Das and Devesh U. Kapoor contributed equally.

Acknowledgments

This work was partially supported by CMU Proactive Researcher Scheme (2023), Chiang Mai University “Contract No. 933/2566.”

  1. Research ethics: Not applicable.

  2. Author contributions: Conceptualization, SS and BGP; methodology, UD and DUK; software, UD and DUK; validation, SS and BGP; investigation, UD and DUK; resources, SS and BGP; data curation, SS and BGP; writing original draft preparation, UD and DUK; writing review and editing, SS and BGP; visualization, BGP; supervision, BGP and SS; project administration, SS and BGP. All authors have read and agreed to the published version of the manuscript.

  3. Competing interests: The authors state no conflict of interest

  4. Research funding: This work was partially supported by CMU Proactive Researcher Scheme (2023), Chiang Mai University “Contract No. 933/2566.” Moreover, authors are thankful to Ganpat University for providing necessary library facilities to acess the related data.

  5. Data availability: Not applicable.

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Received: 2023-12-27
Accepted: 2024-03-20
Published Online: 2024-05-10
Published in Print: 2024-05-27

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Editorial: Chitin structures and pathways as targets for biopesticides and drugs
  4. Review Articles
  5. Chitosan in cancer therapy: a dual role as a therapeutic agent and drug delivery system
  6. Unveiling the potential of chitosan-coated lipid nanoparticles in drug delivery for management of critical illness: a review
  7. Exploring chitin: novel pathways and structures as promising targets for biopesticides
  8. Research Articles
  9. Development of silver-doped copper oxide and chitosan nanocomposites for enhanced antimicrobial activities
  10. Enhancing microbial fuel cell performance through microbial immobilization
  11. Controlled delivery of nikkomycin by PEG coated PLGA nanoparticles inhibits chitin synthase to prevent growth of Aspergillus flavus and Aspergillus fumigatus
https://doi.org/10.1515/znc-2023-0181
Keywords for this article
chitosan; chitin; drug delivery; chitosan-based nanoparticle; cancer

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Editorial: Chitin structures and pathways as targets for biopesticides and drugs
  4. Review Articles
  5. Chitosan in cancer therapy: a dual role as a therapeutic agent and drug delivery system
  6. Unveiling the potential of chitosan-coated lipid nanoparticles in drug delivery for management of critical illness: a review
  7. Exploring chitin: novel pathways and structures as promising targets for biopesticides
  8. Research Articles
  9. Development of silver-doped copper oxide and chitosan nanocomposites for enhanced antimicrobial activities
  10. Enhancing microbial fuel cell performance through microbial immobilization
  11. Controlled delivery of nikkomycin by PEG coated PLGA nanoparticles inhibits chitin synthase to prevent growth of Aspergillus flavus and Aspergillus fumigatus
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