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Double Porphyrin Platinum Conjugates

  • Henri Brunner EMAIL logo and Karl-Martin Schellerer
Published/Copyright: June 2, 2014
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Zeitschrift für Naturforschung B
From the journal Zeitschrift für Naturforschung B Volume 57 Issue 7

Platinum-containing groups and porphyrins in the same molecule not only show additivity of the dark toxicity of the platinum moiety and the phototoxicity of the porphyrin system but also a selective enrichment of porphyrin platinum conjugates in tumor tissues compared to platinum-only drugs. Porphyrin platinum conjugates containing amino-porphyrin non-leaving groups and porphyrin-carboxylate leaving groups were synthesized and tested with the mammary carcinoma cell line MDA-MB-231.

Keywords: Tumor Therapy; Cytotoxicity; Phototoxicity
Received: 2002-3-11
Published Online: 2014-6-2
Published in Print: 2002-7-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

Articles in the same Issue

  1. Wechselwirkungen in Molekülkristallen, 179 [1, 2]. σ-Donator/Akzeptor-Komplexe {I2C=CI2···X⊖ } (X⊖ = Cl⊖ , Br⊖ , I⊖ , SCN⊖ ) von Tetraiodethen in Tetra(n-butyl)ammoniumhalogenid-Salzen / Interaction in Molecular Crystals, 179 [1, 2]. σ-Donor/Acceptor Complexes {I2C=CI2···X⊖} (X⊖= Cl⊖, Br⊖, I⊖, SCN⊖) of Tetraiodoethene in Tetra(n-butyl)ammonium Halide Salts
  2. Silanolato-Komplexe von Vanadium (III, IV) / Silanolato Complexes of Vanadium (III, IV)
  3. Improved Synthesis of HOPh2Si-SiPh2OH and Crystal Structure Analyses of HOPh2Si-SiPh2OH and HOPh2Si-SiPh2-O-Ph2Si-SiPh2OH·1/2C6H6
  4. Synthesis, Characterisation and Crystal Structure of a Cyano-Bridged Polymeric Yttrium-Iron Complex {[Y(phen)2(H2O)2Fe(CN)6]·8H2O}n
  5. 1,1-Ethylborationof Diethynyl(dimethyl)silane: Formation of a Silole Followed by [4+2]Cycloadditions to 7-Silanorbornadienes and 7-Silanorbornenes
  6. Octahedral Complexes of Fe(III) with Phosphorylic Ligands Closely Related to β-Diketones
  7. Double Porphyrin Platinum Conjugates
  8. Übergangsmetallorganisch stabilisierte Indate und Germanate: Synthese, Struktur und Eigenschaften der Komplexe [{(CO)5M}EX3]2– (M = Cr, Mo, W; E = In; X = Cl, Br), [(CO5Cr)InBr(μ2-Br)]22– sowie [{(CO)5Cr}E(oxinat)2]n– (E = In, n = 2; E = Ge, n = 1) / Organometallically Protected Indates and Germanates: Synthesis, Structure and Properties of [{(CO)5M}EX3]2- (M = Cr, Mo, W; E = In; X = Cl, Br), [(CO5Cr)InBr(μ2-Br)]22- and [{(CO)5Cr}E(oxinat)2]n- (E = In, n = 2; E = Ge, n = 1)
  9. A Homoleptic Zirconium Complex with Four Bulky η2-Pyrazolato Ligands
  10. Polysulfonylamine, CLV [1]. Starke und schwache Wasserstoffbrücken in den Kristallstrukturen von 2,2΄-Bipyridinium-, 1,10-Phenanthrolinium- und 1,8-Bis(dimethylamino)naphthalinium-dimesylamid / Polysulfonylamines, CLV [1]. Strong and Weak Hydrogen Bonding in the Crystal Structures of 2,2΄-Bipyridinium, 1,10-Phenanthrolinium and 1,8-Bis(dimethylamino)naphthalinium Dimesylamide
  11. Synthesis, Structure, and Magnetic Properties of CeNiIn2
  12. Ternary Indides LnRhIn2 (Ln = La, Ce, Pr, Nd, Sm) with MgCuAl2 Type Structure
  13. Palladium Complexes with Bidentate P,N Ligands: Synthesis, Characterization and Application in Ethene Oligomerization
  14. Metallkomplexe mit biologisch wichtigen Liganden, CXLVI [1]. Bis(allyl)-N,O-α-Aminocarboxylat-Rhodium-Komplexe / Metal Complexes of Biologically Important Ligands, CXLVI [1]. Bis(allyl)-N,O-α-Aminocarboxylate-Rhodium Complexes
  15. Borate, an Effective Mummification Agent in Pharaonic Egypt
  16. 2"-Chartreusin-monoacetate, a New Natural Product with Unusual Anisotropy Effects from the Marine Isolate Streptomyces sp. B5525, and its 4"-Isomer
  17. Synthesis and Crystal Structures of Two Monomeric Methylene Bis(diaminoalanes)
https://doi.org/10.1515/znb-2002-0707
Keywords for this article
Tumor Therapy; Cytotoxicity; Phototoxicity

Articles in the same Issue

  1. Wechselwirkungen in Molekülkristallen, 179 [1, 2]. σ-Donator/Akzeptor-Komplexe {I2C=CI2···X⊖ } (X⊖ = Cl⊖ , Br⊖ , I⊖ , SCN⊖ ) von Tetraiodethen in Tetra(n-butyl)ammoniumhalogenid-Salzen / Interaction in Molecular Crystals, 179 [1, 2]. σ-Donor/Acceptor Complexes {I2C=CI2···X⊖} (X⊖= Cl⊖, Br⊖, I⊖, SCN⊖) of Tetraiodoethene in Tetra(n-butyl)ammonium Halide Salts
  2. Silanolato-Komplexe von Vanadium (III, IV) / Silanolato Complexes of Vanadium (III, IV)
  3. Improved Synthesis of HOPh2Si-SiPh2OH and Crystal Structure Analyses of HOPh2Si-SiPh2OH and HOPh2Si-SiPh2-O-Ph2Si-SiPh2OH·1/2C6H6
  4. Synthesis, Characterisation and Crystal Structure of a Cyano-Bridged Polymeric Yttrium-Iron Complex {[Y(phen)2(H2O)2Fe(CN)6]·8H2O}n
  5. 1,1-Ethylborationof Diethynyl(dimethyl)silane: Formation of a Silole Followed by [4+2]Cycloadditions to 7-Silanorbornadienes and 7-Silanorbornenes
  6. Octahedral Complexes of Fe(III) with Phosphorylic Ligands Closely Related to β-Diketones
  7. Double Porphyrin Platinum Conjugates
  8. Übergangsmetallorganisch stabilisierte Indate und Germanate: Synthese, Struktur und Eigenschaften der Komplexe [{(CO)5M}EX3]2– (M = Cr, Mo, W; E = In; X = Cl, Br), [(CO5Cr)InBr(μ2-Br)]22– sowie [{(CO)5Cr}E(oxinat)2]n– (E = In, n = 2; E = Ge, n = 1) / Organometallically Protected Indates and Germanates: Synthesis, Structure and Properties of [{(CO)5M}EX3]2- (M = Cr, Mo, W; E = In; X = Cl, Br), [(CO5Cr)InBr(μ2-Br)]22- and [{(CO)5Cr}E(oxinat)2]n- (E = In, n = 2; E = Ge, n = 1)
  9. A Homoleptic Zirconium Complex with Four Bulky η2-Pyrazolato Ligands
  10. Polysulfonylamine, CLV [1]. Starke und schwache Wasserstoffbrücken in den Kristallstrukturen von 2,2΄-Bipyridinium-, 1,10-Phenanthrolinium- und 1,8-Bis(dimethylamino)naphthalinium-dimesylamid / Polysulfonylamines, CLV [1]. Strong and Weak Hydrogen Bonding in the Crystal Structures of 2,2΄-Bipyridinium, 1,10-Phenanthrolinium and 1,8-Bis(dimethylamino)naphthalinium Dimesylamide
  11. Synthesis, Structure, and Magnetic Properties of CeNiIn2
  12. Ternary Indides LnRhIn2 (Ln = La, Ce, Pr, Nd, Sm) with MgCuAl2 Type Structure
  13. Palladium Complexes with Bidentate P,N Ligands: Synthesis, Characterization and Application in Ethene Oligomerization
  14. Metallkomplexe mit biologisch wichtigen Liganden, CXLVI [1]. Bis(allyl)-N,O-α-Aminocarboxylat-Rhodium-Komplexe / Metal Complexes of Biologically Important Ligands, CXLVI [1]. Bis(allyl)-N,O-α-Aminocarboxylate-Rhodium Complexes
  15. Borate, an Effective Mummification Agent in Pharaonic Egypt
  16. 2"-Chartreusin-monoacetate, a New Natural Product with Unusual Anisotropy Effects from the Marine Isolate Streptomyces sp. B5525, and its 4"-Isomer
  17. Synthesis and Crystal Structures of Two Monomeric Methylene Bis(diaminoalanes)
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