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At a PI3K crossroads: lessons from flies and rodents
-
Angel Acebes
and
Miguel Morales
Published/Copyright:
February 1, 2012
Abstract
PI3K activation is the starting point of signaling pathways relaying on changes in the phosphorylation levels of membrane phosphoinositides. These pathways have been involved in several neuronal processes, including cellular growth and survival, differentiation, neuroprotection, dendritic growing, and synaptic plasticity among others. Recent data from Drosophila and rodents have demonstrated an unexpected role of PI3K controlling synapse number that lead to functional and behavioral effects. In the short-term, PI3K is also required for maintaining AMPA receptor clustering at the postsynaptic membranes. We review here the PI3K roles regulating synapse number and functionality.
Keywords: AMPA receptors; dendritic spines; Drosophila; LTP; PI3K; rodents; synapse number; synaptogenic pathway
Received: 2011-9-10
Accepted: 2011-10-7
Published Online: 2012-02-01
Published in Print: 2012-02-01
©2012 by Walter de Gruyter Berlin Boston
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Keywords for this article
AMPA receptors;
dendritic spines;
Drosophila;
LTP;
PI3K;
rodents;
synapse number;
synaptogenic pathway
Articles in the same Issue
- GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease
- Mitochondrial and metabolic-based protective strategies in Huntington’s disease: the case of creatine and coenzyme Q
- At a PI3K crossroads: lessons from flies and rodents
- Theta phase precession beyond the hippocampus
- The role of Ca2+-stimulated adenylyl cyclases in bidirectional synaptic plasticity and brain function
- Endoplasmic reticulum stress and prion diseases
- Head models and dynamic causal modeling of subcortical activity using magnetoencephalographic/electroencephalographic data
- The role of glutamatergic inputs onto parvalbumin-positive interneurons: relevance for schizophrenia
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