Spontaneously hypertensive rat (SHR) as an animal model for ADHD: a short overview
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Alfredo Meneses
,
Georgina Perez-Garcia
Abstract
Diverse studies indicate that attention-deficit hyperactivity disorder (ADHD) is associated with alterations in encoding processes, including working or short-term memory. Some ADHD dysfunctional domains are reflected in the spontaneously hypertensive rat (SHR). Because ADHD, drugs and animal models are eliciting a growing interest, hence the aim of this work is to present a brief overview with a focus on the SHR as an animal model for ADHD and memory deficits. Thus, this paper reviews the concept of SHR as a model system for ADHD, comparing SHR, Wistar-Kyoto and Sprague-Dawley rats with a focus on the hypertension level and working, short-term memory and attention in different behavioral tasks, such as open field, five choice serial reaction time, water maze, passive avoidance, and autoshaping. In addition, drug treatments (d-amphetamine and methylphenidate) are evaluated.
©2011 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Publisher’s Note
- Impoverished environment, cognition, aging and dementia
- When is adult hippocampal neurogenesis necessary for learning? Evidence from animal research
- Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer’s disease
- Cytokines and depression: findings, issues, and treatment implications
- BDNF-TrkB signalling in fear learning: from genetics to neural networks
- Role of the basolateral amygdala and NMDA receptors in higher-order conditioned fear
- Allosteric modulation of ATP-gated P2X receptor channels
- Current perspectives on potential role of albumin in neuroprotection
- Spontaneously hypertensive rat (SHR) as an animal model for ADHD: a short overview
