A drug pharmacodynamics and pharmacokinetics based approach towards stabilization of HIV infection dynamics
-
Rufina M. Tretyakova
Abstract
In our study we developed a computational algorithm for finding optimal dosages of antiretroviral drug administration for the stabilization of HIV load at low levels. The novelty is that the pharmacokinetics and pharmacodynamics of the antiretroviral drugs were taken into account. A standard closed-loop control of HIV dynamics was constructed that stabilizes the viral load and the optimal drug administration mode was formulated. We analyze the appropriateness of the ‘drug efficacy’ based control and its relationship to a realistic drug dosage and kinetic models in the human body. The translation of the efficacy function into drug concentration is implemented via the pharmacodynamics model of the drug effect. Optimal approximation of the idealized concentration functions is based on the orthogonal projection on linear subspace of drug pharmacokinetics functions.
© 2015 by Walter de Gruyter Berlin/Boston
Articles in the same Issue
- Frontmatter
- Virtual blunt injury of human thorax: age-dependent response of vascular system
- Virtual fractional flow reserve assessment in patient-specific coronary networks by 1D hemodynamic model
- Viscous dissipation energy as a risk factor in multiple cerebral aneurysms
- The study of antitumor efficacy of bevacizumab antiangiogenic therapy using a mathematical model
- A drug pharmacodynamics and pharmacokinetics based approach towards stabilization of HIV infection dynamics
Articles in the same Issue
- Frontmatter
- Virtual blunt injury of human thorax: age-dependent response of vascular system
- Virtual fractional flow reserve assessment in patient-specific coronary networks by 1D hemodynamic model
- Viscous dissipation energy as a risk factor in multiple cerebral aneurysms
- The study of antitumor efficacy of bevacizumab antiangiogenic therapy using a mathematical model
- A drug pharmacodynamics and pharmacokinetics based approach towards stabilization of HIV infection dynamics
