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Pareto frontier visualization in multi-criteria search for efficient therapy strategies: HIV infection example
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A. V. Lotov
Published/Copyright:
February 26, 2013
Abstract
Visualization of the Pareto frontier is a new approach in multi-criteria decision making, i.e. searching for efficient decisions taking multiple decision criteria into account. In this paper, visualization of the Pareto frontier is used in the process of multi-criteria search for efficient strategies of HIV therapy. By using a non-linear mathematical model of virus dynamics, which takes into account the phenomenon of virus variability under the influence of a drug, we show that in the framework of the model it is possible to construct a therapy strategy that balances the conflicting requirements imposed on the therapy process.
Published Online: 2013-02-26
Published in Print: 2012-10
© 2013 by Walter de Gruyter GmbH & Co.
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Articles in the same Issue
- Masthead
- Conservative algorithm of substance transport over a closed graph of cardiovascular system
- Modelling of bioimpedance measurements: unstructured mesh application to real human anatomy
- Pareto frontier visualization in multi-criteria search for efficient therapy strategies: HIV infection example
- Discrete stochastic model of HIV infection spread within a heterogeneous population
- Interaction of simulation and analytic methods in modelling of ecological and biological objects
- Action potential propagation and phase dynamics in the sinoatrial node
- Modelling of thrombus growth and growth stop in flow by the method of dissipative particle dynamics
