Abstract
This review highlights recent data concerning the synthesis of brain metabolic DNA (BMD) by cytoplasmic reverse transcription and the prompt acquisition of the double-stranded configuration that allows its partial transfer to nuclei. BMD prevails in the mitochondrial fraction and is present in presynaptic regions and astroglial processes where it undergoes a turnover lasting a few weeks. Additional data demonstrate that BMD sequences are modified by learning, thus indicating that the modified synaptic activity allowing proper brain responses is encoded in learning BMD. In addition, several converging observations regarding the origin of BMD strongly suggest that BMD is reverse transcribed by mitochondrial telomerase.
Acknowledgments
We warmly thank Prof. Carla Perrone Capano and Marianna Crispino from the Federico II University in Naples, Italy, for their improving comments to our article.
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Conflict of interest statement: The authors declare no conflict of interest.
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Articles in the same Issue
- Frontmatter
- Circulating microparticles in patients after ischemic stroke: a systematic review and meta-analysis
- Efficacy and safety of endovascular treatment for patients with acute intracranial atherosclerosis–related posterior circulation stroke: a systematic review and meta-analysis
- Neuroprotection of hypoxic/ischemic preconditioning in neonatal brain with hypoxic-ischemic injury
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Articles in the same Issue
- Frontmatter
- Circulating microparticles in patients after ischemic stroke: a systematic review and meta-analysis
- Efficacy and safety of endovascular treatment for patients with acute intracranial atherosclerosis–related posterior circulation stroke: a systematic review and meta-analysis
- Neuroprotection of hypoxic/ischemic preconditioning in neonatal brain with hypoxic-ischemic injury
- Treatment for mitochondrial diseases
- The role of melatonin and its analogues in epilepsy
- Gut microbiota on gender bias in autism spectrum disorder
- BDNF and nicotine dependence: associations and potential mechanisms
- Brain metabolic DNA: recent evidence for a mitochondrial connection
- Channels to consciousness: a possible role of gap junctions in consciousness