Abstract
According to recent research, disturbances of self-awareness and conscious experience have a critical role in the pathophysiology of schizophrenia, and in this context, schizophrenia is currently understood as a disorder characterized by distortions of acts of awareness, self-consciousness, and self-monitoring. Together, these studies suggest that the processes of disrupted awareness and conscious disintegration in schizophrenia might be related and represented by similar disruptions on the brain level, which, in principle, could be explained by various levels of disturbed connectivity and information disintegration that may negatively affect usual patterns of synchronous activity constituting adaptive integrative functions of consciousness. On the other hand, mental integration based on self-awareness and insight may significantly increase information integration and directly influence neural mechanisms underlying basic pathophysiological processes in schizophrenia.
Acknowledgments
The study was supported by the Charles University grant (PRVOUK and SVV), a project provided by the Czech Ministry of Education (LH11032), and the project ‘CEITEC–Central European Institute of Technology’ (CZ.1.05/1.1.00/02.0068) from the European Regional Development Fund.
References
Aleman, A., Agrawal, N., Morgan, K.D., and David, A.S. (2006). Insight in psychosis and neuropsychological function: meta-analysis. Br. J. Psychiatry 189, 204–212.10.1192/bjp.189.3.204Search in Google Scholar
Amador, X.F. and Gorman, J.M. (1998). Psychopathologic domains and insight in schizophrenia. Psychiatr. Clin. North Am. 21, 27–42.10.1016/S0193-953X(05)70359-2Search in Google Scholar
Amador, X.F., Strauss, D.H., Yale, S.A., and Gorman, J.M. (1991). Awareness of illness in schizophrenia. Schizophr. Bull. 17, 113–132.10.1093/schbul/17.1.113Search in Google Scholar
Amador, X.F., Strauss, D.H., Yale, S.A., Flaum, M.M., Endicott, J., and Gorman, J.M. (1993). Assessment of insight in psychosis. Am. J. Psychiatr. 150, 873–879.10.1176/ajp.150.6.873Search in Google Scholar
Amador, X.F., Flaum, M., Andreasen, N.C., Strauss, D.H., Yale, S.A., Clark, S.C., and Gorman, J.M. (1994). Awareness of illness in schizophrenia and schizoaffective and mood disorders. Arch. Gen. Psychiatry 51, 826–836.10.1001/archpsyc.1994.03950100074007Search in Google Scholar
American Psychiatric Association (2013). The Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (Arlington, VA: American Psychiatric Association).10.1176/appi.books.9780890425596Search in Google Scholar
Ayesa-Arriola, R., Morinigo, J.D., David, A.S., Perez-Iglesias, R., Rodriguez-Sanchez, J.M., and Crespo-Facorro, B. (2014). Lack of insight 3 years after first-episode psychosis: an unchangeable illness trait determined from first presentation? Schizophr. Res. 157, 271–277.Search in Google Scholar
Baars, B.J. (2002). The conscious access hypothesis: origins and recent evidence. Trends Cogn. Sci. 6, 47–52.10.1016/S1364-6613(00)01819-2Search in Google Scholar
Baars, B.J., Franklin, S., and Ramsoy, T.Z. (2013). Global workspace dynamics: cortical “binding and propagation” enables conscious contents. Front. Psychol. 4, 200.10.3389/fpsyg.2013.00200Search in Google Scholar
Beck, A.T., Baruch, E., Balter, J.M., Steer, R.A., and Warman, D.M. (2004). A new instrument for measuring insight: the Beck Cognitive Insight Scale. Schizophr. Res. 68, 319–329.10.1016/S0920-9964(03)00189-0Search in Google Scholar
Bennett, M.R. (2007). Development of the concept of mind. Aust. N. Z. J. Psychiatry 41, 943–956.10.1080/00048670701689477Search in Google Scholar PubMed
Bhattacharya, J. and Petsche, H. (2002). Shadows of artistry: cortical synchrony during perception and imagery of visual art. Brain Res. Cogn. Brain Res. 13, 179–186.10.1016/S0926-6410(01)00110-0Search in Google Scholar
Birchwood, M., Smith, J., Drury, V., Healy, J., Macmillan, F., and Slade, M. (1994). A self-report insight scale for psychosis: reliability, validity and sensitivity to change. Acta Psychiatr. Scand. 89, 62–67.10.1111/j.1600-0447.1994.tb01487.xSearch in Google Scholar PubMed
Bleuler, E. (1950). Dementia Praecox or the Group of Schizophrenias (J. Zinkin, Trans.) (New York: International Universities Press).Search in Google Scholar
Bleuler, E. and Brill, A.A. (1924). Textbook of Psychiatry (Oxford: Macmillan).Search in Google Scholar
Bob, P. (2003). Subliminal processes, dissociation and the’I’. J. Anal. Psychol. 48, 307–316.10.1111/1465-5922.t01-4-00002Search in Google Scholar PubMed
Bob, P. (2004). Dissociative processes, multiple personality, and dream functions. Am. J. Psychother. 58, 139–149.10.1176/appi.psychotherapy.2004.58.2.139Search in Google Scholar PubMed
Bob, P. (2011). Brain, Mind and Consciousness: Advances in Neuroscience Research (New York: Springer).10.1007/978-1-4614-0436-1Search in Google Scholar
Bob, P. (2012). Consciousness, schizophrenia and complexity. Cogn. Syst. Res. 13, 87–94.10.1016/j.cogsys.2011.05.001Search in Google Scholar
Bob, P. and Mashour, G.A. (2011). Schizophrenia, dissociation, and consciousness. Conscious. Cogn. 20, 1042–1049.10.1016/j.concog.2011.04.013Search in Google Scholar PubMed
Bob, P., Palus, M., Susta, M., and Glaslova, K. (2008). EEG phase synchronization in patients with paranoid schizophrenia. Neurosci. Lett. 447, 73–77.10.1016/j.neulet.2008.09.055Search in Google Scholar PubMed
Bora, E., Yucel, M., and Pantelis, C. (2009). Theory of mind impairment in schizophrenia: meta-analysis. Schizophr. Res. 109, 1–9.10.1016/j.schres.2008.12.020Search in Google Scholar PubMed
Bourgeois, M., Swendsen, J., Young, F., Amador, X., Pini, S., Cassano, G.B., Lindenmayer, J.P., Hsu, C., Alphs, L., Meltzer, H.Y., et al. (2004). Awareness of disorder and suicide risk in the treatment of schizophrenia: results of the international suicide prevention trial. Am. J. Psychiatry 161, 1494–1496.10.1176/appi.ajp.161.8.1494Search in Google Scholar PubMed
Bowden, E.M., Jung-Beeman, M., Fleck, J., and Kounios, J. (2005). New approaches to demystifying insight. Trends Cogn. Sci. 9, 322–328.10.1016/j.tics.2005.05.012Search in Google Scholar PubMed
Buchy, L., Torres, I.J., Liddle, P.F., and Woodward, T.S. (2009). Symptomatic determinants of insight in schizophrenia spectrum disorders. Compr. Psychiatry 50, 578–583.10.1016/j.comppsych.2009.01.007Search in Google Scholar PubMed
Carr, V. and Wale, J. (1986). Schizophrenia: an information processing model. Aust. N. Z. J. Psychiatry 20, 136–155.10.3109/00048678609161327Search in Google Scholar PubMed
Carroll, A., Pantelis, C., and Harvey, C. (2004). Insight and hopelessness in forensic patients with schizophrenia. Aust. N. Z. J. Psychiatry 38, 169–173.10.1080/j.1440-1614.2004.01315.xSearch in Google Scholar PubMed
Cavinato, M., Genna, C., Manganotti, P., Formaggio, E., Storti, S.F., Campostrini, S., Arcaro, C., Casanova, E., Petrone, V., Piperno, R., et al. (2014). Coherence and consciousness: study of fronto-parietal gamma synchrony in patients with disorders of consciousness. Brain Topogr. doi:10.1007/s10548-014-0383-5.10.1007/s10548-014-0383-5Search in Google Scholar PubMed
Comparelli, A., Savoja, V., De Carolis, A., Di Pietro, S., Kotzalidis, G.D., Corigliano, V., Falcone, I., Tatarelli, R., Ferracuti, S., and Girardi, P. (2013). Relationships between psychopathological variables and insight in psychosis risk syndrome and first-episode and multiepisode schizophrenia. J. Nerv. Ment. Dis. 201, 229–233.10.1097/NMD.0b013e3182834315Search in Google Scholar PubMed
Crick, F. and Koch, C. (1992). The problem of consciousness. Sci. Am. 267, 152–159.10.1038/scientificamerican0992-152Search in Google Scholar PubMed
Crossley, N.A., Mechelli, A., Fusar-Poli, P., Broome, M.R., Matthiasson, P., Johns, L.C., Bramon, E., Valmaggia, L., Williams, S.C., and McGuire, P.K. (2009). Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis. Hum. Brain Mapp. 30, 4129–4137.10.1002/hbm.20834Search in Google Scholar PubMed PubMed Central
Crumlish, N., Whitty, P., Kamali, M., Clarke, M., Browne, S., McTigue, O., Lane, A., Kinsella, A., Larkin, C., and O’Callaghan, E. (2005). Early insight predicts depression and attempted suicide after 4 years in first-episode schizophrenia and schizophreniform disorder. Acta Psychiatr. Scand. 112, 449–455.10.1111/j.1600-0447.2005.00620.xSearch in Google Scholar PubMed
Cuesta, M.J. and Peralta, V. (1994). Lack of insight in schizophrenia. Schizophr. Bull. 20, 359–366.10.1093/schbul/20.2.359Search in Google Scholar PubMed
Cuesta, M.J., Peralta, V., Zarzuela, A., and Zandio, M. (2006). Insight dimensions and cognitive function in psychosis: a longitudinal study. BMC Psychiatry 6, 26.10.1186/1471-244X-6-26Search in Google Scholar
Danko, S.G., Shemiakina, N.V., Nagornova, Zh, V., and Starchenko, M.G. (2009). [Comparison of the effects of the subjective complexity and creativity of verbal activity on the EEG power spectral parameters]. Fiziol. Cheloveka 35, 132–134.Search in Google Scholar
David, A.S. (1990). Insight and psychosis. Br. J. Psychiatry 156, 798–808.10.1192/bjp.156.6.798Search in Google Scholar
David, A., Buchanan, A., Reed, A., and Almeida, O. (1992). The assessment of insight in psychosis. Br. J. Psychiatry 161, 599–602.10.1192/bjp.161.5.599Search in Google Scholar
Davis, A., Paulsen, J., Heaton, R., and Jeste, D. (1995). Assessment of the semantic network in chronic schizophrenia. J. Int. Neuropsychol. Soc. 1, 132.Search in Google Scholar
Dietrich, A. and Kanso, R. (2010). A review of EEG, ERP, and neuroimaging studies of creativity and insight. Psychol. Bull. 136, 822–848.10.1037/a0019749Search in Google Scholar
Doesburg, S.M., Kitajo, K., and Ward, L.M. (2005). Increased gamma-band synchrony precedes switching of conscious perceptual objects in binocular rivalry. Neuroreport 16, 1139–1142.10.1097/00001756-200508010-00001Search in Google Scholar
Donohoe, G., Donnell, C.O., Owens, N., and O’Callaghan, E. (2004). Evidence that health attributions and symptom severity predict insight in schizophrenia. J. Nerv. Ment. Dis. 192, 635–637.10.1097/01.nmd.0000138318.05729.dbSearch in Google Scholar
Edelman, G.M. (2003). Naturalizing consciousness: a theoretical framework. Proc. Natl. Acad. Sci. USA. 100, 5520–5524.10.1073/pnas.0931349100Search in Google Scholar
Edelman, G.M., Gally, J.A., and Baars, B.J. (2011). Biology of consciousness. Front. Psychol. 2, 4.10.3389/fpsyg.2011.00004Search in Google Scholar
Engel, A.K. and Singer, W. (2001). Temporal binding and the neural correlates of sensory awareness. Trends Cogn. Sci. 5, 16–25.10.1016/S1364-6613(00)01568-0Search in Google Scholar
Feinberg, I. (1978). Efference copy and corollary discharge: implications for thinking and its disorders. Schizophr. Bull. 4, 636–640.10.1093/schbul/4.4.636Search in Google Scholar PubMed
Fishman, R.S. (2008). The study of the wonderful: the first topographical mapping of vision in the brain. Arch. Ophthalmol. 126, 1767–1773.10.1001/archopht.126.12.1767Search in Google Scholar
Foote, B. and Park, J. (2008). Dissociative identity disorder and schizophrenia: differential diagnosis and theoretical issues. Curr. Psychiatry Rep. 10, 217–222.10.1007/s11920-008-0036-zSearch in Google Scholar
Ford, J.M. and Mathalon, D.H. (2005). Corollary discharge dysfunction in schizophrenia: can it explain auditory hallucinations? Int. J. Psychophysiol. 58, 179–189.10.1016/j.ijpsycho.2005.01.014Search in Google Scholar
Ford, J.M., Mathalon, D.H., Heinks, T., Kalba, S., Faustman, W.O., and Roth, W.T. (2001). Neurophysiological evidence of corollary discharge dysfunction in schizophrenia. Am. J. Psychiatry 158, 2069–2071.10.1176/appi.ajp.158.12.2069Search in Google Scholar
Ford, J.M., Gray, M., Faustman, W.O., Roach, B.J., and Mathalon, D.H. (2007). Dissecting corollary discharge dysfunction in schizophrenia. Psychophysiology 44, 522–529.10.1111/j.1469-8986.2007.00533.xSearch in Google Scholar
Ford, J.M., Roach, B.J., Faustman, W.O., and Mathalon, D.H. (2008). Out-of-synch and out-of-sorts: dysfunction of motor-sensory communication in schizophrenia. Biol. Psychiatry 63, 736–743.10.1016/j.biopsych.2007.09.013Search in Google Scholar
Forrest, K.A. (2001). Toward an etiology of dissociative identity disorder: a neurodevelopmental approach. Conscious. Cogn. 10, 259–293.10.1006/ccog.2001.0493Search in Google Scholar
Fries, P., Reynolds, J.H., Rorie, A.E., and Desimone, R. (2001). Modulation of oscillatory neuronal synchronization by selective visual attention. Science 291, 1560–1563.10.1126/science.1055465Search in Google Scholar
Friston, K.J. and Frith, C.D. (1995). Schizophrenia: a disconnection syndrome? Clin. Neurosci. 3, 89–97.Search in Google Scholar
Frith, C.D. (1987). The positive and negative symptoms of schizophrenia reflect impairments in the perception and initiation of action. Psychol. Med. 17, 631–648.10.1017/S0033291700025873Search in Google Scholar
Frith, C.D. (1992). The Cognitive Neuropsychology of Schizophrenia (Hillsdale, NJ: Erlbaum).Search in Google Scholar
Gallagher, I.I. (2000). Philosophical conceptions of the self: implications for cognitive science. Trends Cogn. Sci. 4, 14–21.10.1016/S1364-6613(99)01417-5Search in Google Scholar
Goldberg, T.E. and Weinberger, D.R. (2000). Thought disorder in schizophrenia: a reappraisal of older formulations and an overview of some recent studies. Cogn. Neuropsychiatry 5, 1–19.10.1080/135468000395790Search in Google Scholar
Gray, C.M. and Singer, W. (1989). Stimulus-specific neuronal oscillations in orientation columns of cat visual cortex. Proc. Natl. Acad. Sci. USA. 86, 1698–1702.10.1073/pnas.86.5.1698Search in Google Scholar
Gray, C.M., Konig, P., Engel, A.K., and Singer, W. (1989). Oscillatory responses in cat visual cortex exhibit inter-columnar synchronization which reflects global stimulus properties. Nature 338, 334–337.10.1038/338334a0Search in Google Scholar
Gray, J.A., Feldon, J., Rawlins, J., Hemsley, D., and Smith, A. (1991). The neuropsychology of schizophrenia. Behav. Brain Sci. 14, 1–20.10.1017/S0140525X00065055Search in Google Scholar
Hemsley, D.R. (2005). The development of a cognitive model of schizophrenia: placing it in context. Neurosci. Biobehav. Rev. 29, 977–988.10.1016/j.neubiorev.2004.12.008Search in Google Scholar
Holt, D.J., Cassidy, B.S., Andrews-Hanna, J.R., Lee, S.M., Coombs, G., Goff, D.C., Gabrieli, J.D., and Moran, J.M. (2011). An anterior-to-posterior shift in midline cortical activity in schizophrenia during self-reflection. Biol. Psychiatry 69, 415–423.10.1016/j.biopsych.2010.10.003Search in Google Scholar
Hwang, S.S., Chang, J.S., Lee, K.Y., Ahn, Y.M., and Kim, Y.S. (2009). The causal model of insight in schizophrenia based on the Positive and Negative Syndrome Scale factors and the structural equation modeling. J. Nerv. Ment. Dis. 197, 79–84.10.1097/NMD.0b013e318196083eSearch in Google Scholar
Janet, P. (1890). L’Automatisme Psychologique (Paris: Felix Alcon).Search in Google Scholar
Jung, C. (1909). The Psychology of Dementia Praecox (New York: Journal of Nervous and Mental Disease Publishing Company).Search in Google Scholar
Jung-Beeman, M., Bowden, E.M., Haberman, J., Frymiare, J.L., Arambel-Liu, S., Greenblatt, R., Reber, P.J., and Kounios, J. (2004). Neural activity when people solve verbal problems with insight. PLoS Biol. 2, E97.10.1371/journal.pbio.0020097Search in Google Scholar
Kemp, R.A. and Lambert, T.J. (1995). Insight in schizophrenia and its relationship to psychopathology. Schizophr. Res. 18, 21–28.10.1016/0920-9964(95)00018-6Search in Google Scholar
Kent, G.H. and Rosonoff, A.J. (1910). A study of associations in insanity. Am. J. Insanity 66/67, 317–390.10.1037/13767-000Search in Google Scholar
Keshavan, M.S., Rabinowitz, J., DeSmedt, G., Harvey, P.D., and Schooler, N. (2004). Correlates of insight in first episode psychosis. Schizophr. Res. 70, 187–194.10.1016/j.schres.2003.11.007Search in Google Scholar
Kihlstrom, J.F. (2005). Dissociative disorders. Annu. Rev. Clin. Psychol. 1, 227–253.10.1146/annurev.clinpsy.1.102803.143925Search in Google Scholar
Kim, C.H., Jayathilake, K., and Meltzer, H.Y. (2003). Hopelessness, neurocognitive function, and insight in schizophrenia: relationship to suicidal behavior. Schizophr. Res. 60, 71–80.10.1016/S0920-9964(02)00310-9Search in Google Scholar
Kircher, T.T. and Leube, D.T. (2003). Self-consciousness, self-agency, and schizophrenia. Conscious. Cogn. 12, 656–669.10.1016/S1053-8100(03)00071-0Search in Google Scholar
Kohler, W. (1925). The Mentality of Apes (Tr. by E. Winter) (London: Routledge and Kegan Paul).Search in Google Scholar
Kounios, J., Fleck, J.I., Green, D.L., Payne, L., Stevenson, J.L., Bowden, E.M., and Jung-Beeman, M. (2008). The origins of insight in resting-state brain activity. Neuropsychologia 46, 281–291.10.1016/j.neuropsychologia.2007.07.013Search in Google Scholar
Kuhn, S. and Gallinat, J. (2013). Resting-state brain activity in schizophrenia and major depression: a quantitative meta-analysis. Schizophr. Bull. 39, 358–365.10.1093/schbul/sbr151Search in Google Scholar
Lee, K.H., Williams, L.M., Breakspear, M., and Gordon, E. (2003). Synchronous gamma activity: a review and contribution to an integrative neuroscience model of schizophrenia. Brain Res. Brain Res. Rev. 41, 57–78.10.1016/S0165-0173(02)00220-5Search in Google Scholar
Lee, S.H., Kim, D.W., Kim, E.Y., Kim, S., and Im, C.H. (2010). Dysfunctional gamma-band activity during face structural processing in schizophrenia patients. Schizophr. Res. 119, 191–197.10.1016/j.schres.2010.02.1058Search in Google Scholar PubMed
Leisman, G. and Koch, P. (2009). Networks of conscious experience: computational neuroscience in understanding life, death, and consciousness. Rev. Neurosci. 20, 151–176.10.1515/REVNEURO.2009.20.3-4.151Search in Google Scholar PubMed
Li, D. and Spiegel, D. (1992). A neural network model of dissociative disorders. Psychiatr. Ann. 22, 144–147.10.3928/0048-5713-19920301-11Search in Google Scholar
Lincoln, T.M., Lullmann, E., and Rief, W. (2007). Correlates and long-term consequences of poor insight in patients with schizophrenia. A systematic review. Schizophr. Bull. 33, 1324–1342.10.1093/schbul/sbm002Search in Google Scholar
Lou, H.C. (2012). Paradigm shift in consciousness research: the child’s self-awareness and abnormalities in autism, ADHD and schizophrenia. Acta Paediatr. 101, 112–119.10.1111/j.1651-2227.2011.02456.xSearch in Google Scholar
Lou, H.C., Gross, J., Biermann-Ruben, K., Kjaer, T.W., and Schnitzler, A. (2010). Coherence in consciousness: paralimbic gamma synchrony of self-reference links conscious experiences. Hum. Brain Mapp. 31, 185–192.Search in Google Scholar
Lysaker, P.H., Bryson, G.J., Lancaster, R.S., Evans, J.D., and Bell, M.D. (2003). Insight in schizophrenia: associations with executive function and coping style. Schizophr. Res. 59, 41–47.10.1016/S0920-9964(01)00383-8Search in Google Scholar
Lysaker, P.H., Salvatore, G., Grant, M.L., Procacci, M., Olesek, K.L., Buck, K.D., Nicolo, G., and Dimaggio, G. (2010). Deficits in theory of mind and social anxiety as independent paths to paranoid features in schizophrenia. Schizophr. Res. 124, 81–85.10.1016/j.schres.2010.06.019Search in Google Scholar
Lysaker, P.H., Vohs, J., Hillis, J.D., Kukla, M., Popolo, R., Salvatore, G., and Dimaggio, G. (2013). Poor insight into schizophrenia: contributing factors, consequences and emerging treatment approaches. Expert Rev. Neurother. 13, 785–793.10.1586/14737175.2013.811150Search in Google Scholar
Markova, I. (2005). Insight in Psychiatry (Cambridge: Cambridge University Press).Search in Google Scholar
Markova, I.S. and Berrios, G.E. (1992). The assessment of insight in clinical psychiatry: a new scale. Acta Psychiatr. Scand. 86, 159–164.10.1111/j.1600-0447.1992.tb03245.xSearch in Google Scholar
Markova, I.S. and Berrios, G.E. (1995). Insight in clinical psychiatry. A new model. J. Nerv. Ment. Dis. 183, 743–751.10.1097/00005053-199512000-00003Search in Google Scholar
Marks, K.A., Fastenau, P.S., Lysaker, P.H., and Bond, G.R. (2000). Self-Appraisal of Illness Questionnaire (SAIQ): relationship to researcher-rated insight and neuropsychological function in schizophrenia. Schizophr. Res. 45, 203–211.10.1016/S0920-9964(99)00208-XSearch in Google Scholar
McEvoy, J.P., Freter, S., Everett, G., Geller, J.L., Appelbaum, P., Apperson, L.J., and Roth, L. (1989). Insight and the clinical outcome of schizophrenic patients. J. Nerv. Ment. Dis. 177, 48–51.10.1097/00005053-198901000-00008Search in Google Scholar
Mintz, A.R., Dobson, K.S., and Romney, D.M. (2003). Insight in schizophrenia: a meta-analysis. Schizophr. Res. 61, 75–88.10.1016/S0920-9964(02)00316-XSearch in Google Scholar
Mintz, A.R., Addington, J., and Addington, D. (2004). Insight in early psychosis: a 1-year follow-up. Schizophr. Res. 67, 213–217.10.1016/S0920-9964(03)00047-1Search in Google Scholar
Mishara, A.L. (2007). Is minimal self preserved in schizophrenia? A subcomponents view. Conscious. Cogn. 16, 715–721.10.1016/j.concog.2007.07.009Search in Google Scholar PubMed
Mishara, A.L., Lysaker, P.H., and Schwartz, M.A. (2014). Self-disturbances in schizophrenia: history, phenomenology, and relevant findings from research on metacognition. Schizophr. Bull. 40, 5–12.10.1093/schbul/sbt169Search in Google Scholar PubMed PubMed Central
Modinos, G., Renken, R., Ormel, J., and Aleman, A. (2011). Self-reflection and the psychosis-prone brain: an fMRI study. Neuropsychology 25, 295–305.10.1037/a0021747Search in Google Scholar PubMed
Mohamed, S., Rosenheck, R., McEvoy, J., Swartz, M., Stroup, S., and Lieberman, J.A. (2009). Cross-sectional and longitudinal relationships between insight and attitudes toward medication and clinical outcomes in chronic schizophrenia. Schizophr. Bull. 35, 336–346.10.1093/schbul/sbn067Search in Google Scholar PubMed PubMed Central
Moran, L.J., Mefferd, R.B. Jr., and Kimble, J.P. Jr. (1964). Idiodynamic sets in word association. Psychol. Monogr. 78, 1–22.10.1037/h0093833Search in Google Scholar
Moskowitz, A. (2008). Association and Dissociation in the Historical Concept of Schizophrenia. Psychosis, Trauma and Dissociation: Emerging Perspectives on Severe Psychopathology. A. Moskowitz, I. Schäfer, and M.J. Dorahy, eds. (West Sussex: Wiley-Blackwell), pp. 35–50.10.1002/9780470699652.ch3Search in Google Scholar
Moskowitz, A.K., Barker-Collo, S., and Ellson, L. (2005). Replication of dissociation-psychosis link in New Zealand students and inmates. J. Nerv. Ment. Dis. 193, 722–727.10.1097/01.nmd.0000185895.47704.62Search in Google Scholar PubMed
Mulert, C., Kirsch, V., Pascual-Marqui, R., McCarley, R.W., and Spencer, K.M. (2011). Long-range synchrony of gamma oscillations and auditory hallucination symptoms in schizophrenia. Int. J. Psychophysiol. 79, 55–63.10.1016/j.ijpsycho.2010.08.004Search in Google Scholar PubMed PubMed Central
Oizumi, M., Albantakis, L., and Tononi, G. (2014). From the phenomenology to the mechanisms of consciousness: Integrated Information Theory 3.0. PLoS Comput. Biol. 10, e1003588.10.1371/journal.pcbi.1003588Search in Google Scholar PubMed PubMed Central
Onians, R.B. (1954). The Origins of European Thought (London: Cambridge University Press).Search in Google Scholar
Panagiotaropoulos, T.I., Deco, G., Kapoor, V., and Logothetis, N.K. (2012). Neuronal discharges and gamma oscillations explicitly reflect visual consciousness in the lateral prefrontal cortex. Neuron 74, 924–935.10.1016/j.neuron.2012.04.013Search in Google Scholar
Parnaudeau, S., O’Neill, P.K., Bolkan, S.S., Ward, R.D., Abbas, A.I., Roth, B.L., Balsam, P.D., Gordon, J.A., and Kellendonk, C. (2013). Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition. Neuron 77, 1151–1162.10.1016/j.neuron.2013.01.038Search in Google Scholar
Paulsen, J.S., Romero, R., Chan, A., Davis, A.V., Heaton, R.K., and Jeste, D.V. (1996). Impairment of the semantic network in schizophrenia. Psychiatry Res. 63, 109–121.10.1016/0165-1781(96)02901-0Search in Google Scholar
Peled, A. (1999). Multiple constraint organization in the brain: a theory for schizophrenia. Brain Res. Bull. 49, 245–250.10.1016/S0361-9230(99)00048-9Search in Google Scholar
Pompili, M., Amador, X.F., Girardi, P., Harkavy-Friedman, J., Harrow, M., Kaplan, K., Krausz, M., Lester, D., Meltzer, H.., Modestin, J., et al. (2007). Suicide risk in schizophrenia: learning from the past to change the future. Ann. Gen. Psychiatry 6, 10.10.1186/1744-859X-6-10Search in Google Scholar
Poulet, J.F. and Hedwig, B. (2007). New insights into corollary discharges mediated by identified neural pathways. Trends Neurosci. 30, 14–21.10.1016/j.tins.2006.11.005Search in Google Scholar
Pulvermuller, F. (2002). A brain perspective on language mechanisms: from discrete neuronal ensembles to serial order. Prog. Neurobiol. 67, 85–111.10.1016/S0301-0082(02)00014-XSearch in Google Scholar
Putnam, F.W. (1997). Dissociation in Children and Adolescents: A Developmental Perspective (New York: Guilford Press).Search in Google Scholar
Read, J., van Os, J., Morrison, A.P., and Ross, C.A. (2005). Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr. Scand. 112, 330–350.10.1111/j.1600-0447.2005.00634.xSearch in Google Scholar PubMed
Riggs, S.E., Grant, P.M., Perivoliotis, D., and Beck, A.T. (2012). Assessment of cognitive insight: a qualitative review. Schizophr. Bull. 38, 338–350.10.1093/schbul/sbq085Search in Google Scholar PubMed PubMed Central
Rotenberg, V.S. (1994). The revised monoamine hypothesis: mechanism of antidepressant treatment in the context of behavior. Integr. Physiol. Behav. Sci. 29, 182–188.10.1007/BF02691013Search in Google Scholar PubMed
Rotenberg, V.S. (2004). The peculiarity of the right-hemisphere function in depression: solving the paradoxes. Prog. Neuropsychopharmacol. Biol. Psychiatry 28, 1–13.Search in Google Scholar
Rotenberg, V.S. (2013). Moravec’s paradox: consideration in the context of two brain hemisphere functions. Act. Nerv. Super. (Prague) 55, 108–111.10.1007/BF03379600Search in Google Scholar
Sandkuhler, S. and Bhattacharya, J. (2008). Deconstructing insight: EEG correlates of insightful problem solving. PLoS One 3, e1459.10.1371/journal.pone.0001459Search in Google Scholar PubMed PubMed Central
Scharfetter, C. (2008). Ego-Fragmentation in Schizophrenia: A Severe Dissociation of Self-Experience. Psychosis, Trauma and Dissociation: Emerging Perspectives on Severe Psychopathology. A. Moskowitz, I. Schäfer, and M.J. Dorahy, eds. (West Sussex: Wiley-Blackwell), pp. 51–64.10.1002/9780470699652.ch4Search in Google Scholar
Sevy, S., Nathanson, K., Visweswaraiah, H., and Amador, X. (2004). The relationship between insight and symptoms in schizophrenia. Compr. Psychiatry 45, 16–19.10.1016/j.comppsych.2003.09.002Search in Google Scholar PubMed
Shakow, D. (1980). Kent-Rosanoff association and its implications for segmental set theory. Schizophr. Bull. 6, 676–685.10.1093/schbul/6.4.676Search in Google Scholar PubMed
Sheth, B.R., Sandkuhler, S., and Bhattacharya, J. (2009). Posterior beta and anterior gamma oscillations predict cognitive insight. J. Cogn. Neurosci. 21, 1269–1279.10.1162/jocn.2009.21069Search in Google Scholar PubMed
Shtyrov, Y. and Pulvermuller, F. (2007). Early MEG activation dynamics in the left temporal and inferior frontal cortex reflect semantic context integration. J. Cogn. Neurosci. 19, 1633–1642.10.1162/jocn.2007.19.10.1633Search in Google Scholar PubMed
Siekmeier, P.J. and Stufflebeam, S.M. (2010). Patterns of spontaneous magnetoencephalographic activity in patients with schizophrenia. J. Clin. Neurophysiol. 27, 179–190.10.1097/WNP.0b013e3181e0b20aSearch in Google Scholar PubMed PubMed Central
Singer, W. (1993). Synchronization of cortical activity and its putative role in information processing and learning. Annu. Rev. Physiol. 55, 349–374.10.1146/annurev.ph.55.030193.002025Search in Google Scholar PubMed
Singer, W. (2001). Consciousness and the binding problem. Ann. N. Y. Acad. Sci. 929, 123–146.10.1111/j.1749-6632.2001.tb05712.xSearch in Google Scholar PubMed
Sirois, F. (2012). The role and importance of interpretation in the talking cure. Int. J. Psychoanal. 93, 1377–1402.10.1111/j.1745-8315.2012.00650.xSearch in Google Scholar
Smith, C.U. (1998). Descartes’ pineal neuropsychology. Brain Cogn. 36, 57–72.10.1006/brcg.1997.0954Search in Google Scholar
Smith, R.W. and Kounios, J. (1996). Sudden insight: all-or-none processing revealed by speed-accuracy decomposition. J. Exp. Psychol. Learn. Mem. Cogn. 22, 1443–1462.10.1037/0278-7393.22.6.1443Search in Google Scholar
Smith, T.E., Hull, J.W., Israel, L.M., and Willson, D.F. (2000). Insight, symptoms, and neurocognition in schizophrenia and schizoaffective disorder. Schizophr. Bull. 26, 193–200.10.1093/oxfordjournals.schbul.a033439Search in Google Scholar
Spencer, K.M. (2008). Visual gamma oscillations in schizophrenia: implications for understanding neural circuitry abnormalities. Clin. EEG Neurosci. 39, 65–68.10.1177/155005940803900208Search in Google Scholar
Spencer, K.M., Nestor, P.G., Perlmutter, R., Niznikiewicz, M.A., Klump, M.C., Frumin, M., Shenton, M.E., and McCarley, R.W. (2004). Neural synchrony indexes disordered perception and cognition in schizophrenia. Proc. Natl. Acad. Sci. USA. 101, 17288–17293.10.1073/pnas.0406074101Search in Google Scholar
Spiegel, D. (1997). Trauma, dissociation, and memory. Ann. N. Y. Acad. Sci. 821, 225–237.10.1111/j.1749-6632.1997.tb48282.xSearch in Google Scholar
Sporns, O., Tononi, G., and Edelman, G.M. (2000). Connectivity and complexity: the relationship between neuroanatomy and brain dynamics. Neural Netw. 13, 909–922.10.1016/S0893-6080(00)00053-8Search in Google Scholar
Sporns, O., Tononi, G., and Edelman, G.M. (2002). Theoretical neuroanatomy and the connectivity of the cerebral cortex. Behav. Brain Res. 135, 69–74.10.1016/S0166-4328(02)00157-2Search in Google Scholar
Sprong, M., Schothorst, P., Vos, E., Hox, J., and van Engeland, H. (2007). Theory of mind in schizophrenia: meta-analysis. Br. J. Psychiatry 191, 5–13.10.1192/bjp.bp.107.035899Search in Google Scholar PubMed
Startup, M. (1999). Schizotypy, dissociative experiences and childhood abuse: relationships among self-report measures. Br. J. Clin. Psychol. 38, 333–344.10.1348/014466599162908Search in Google Scholar
Sugarman, A. (2003). A new model for conceptualizing insightfulness in the psychoanalysis of young children. Psychoanal. Q. 72, 325–355.10.1002/j.2167-4086.2003.tb00133.xSearch in Google Scholar
Taylor, J.G. (2011). A neural model of the loss of self in schizophrenia. Schizophr. Bull. 37, 1229–1247.10.1093/schbul/sbq033Search in Google Scholar
Tononi, G. (2004). An information integration theory of consciousness. BMC Neurosci. 5, 42.10.1186/1471-2202-5-42Search in Google Scholar
Tononi, G. and Edelman, G.M. (1998). Consciousness and complexity. Science 282, 1846–1851.10.1126/science.282.5395.1846Search in Google Scholar
Tononi, G. and Edelman, G.M. (2000). Schizophrenia and the mechanisms of conscious integration. Brain Res. Brain Res. Rev. 31, 391–400.10.1016/S0165-0173(99)00056-9Search in Google Scholar
Tononi, G. and Koch, C. (2008). The neural correlates of consciousness: an update. Ann. N. Y. Acad. Sci. 1124, 239–261.10.1196/annals.1440.004Search in Google Scholar PubMed
Uhlhaas, P.J. and Mishara, A.L. (2007). Perceptual anomalies in schizophrenia: integrating phenomenology and cognitive neuroscience. Schizophr. Bull. 33, 142–156.10.1093/schbul/sbl047Search in Google Scholar PubMed PubMed Central
Uhlhaas, P.J. and Singer, W. (2010). Abnormal neural oscillations and synchrony in schizophrenia. Nat. Rev. Neurosci. 11, 100–113.10.1038/nrn2774Search in Google Scholar PubMed
Uhlhaas, P.J. and Singer, W. (2011). The development of neural synchrony and large-scale cortical networks during adolescence: relevance for the pathophysiology of schizophrenia and neurodevelopmental hypothesis. Schizophr. Bull. 37, 514–523.10.1093/schbul/sbr034Search in Google Scholar PubMed PubMed Central
Uhlhaas, P.J., Linden, D.E., Singer, W., Haenschel, C., Lindner, M., Maurer, K., and Rodriguez, E. (2006). Dysfunctional long-range coordination of neural activity during Gestalt perception in schizophrenia. J. Neurosci. 26, 8168–8175.10.1523/JNEUROSCI.2002-06.2006Search in Google Scholar
Uhlhaas, P.J., Haenschel, C., Nikolic, D., and Singer, W. (2008). The role of oscillations and synchrony in cortical networks and their putative relevance for the pathophysiology of schizophrenia. Schizophr. Bull. 34, 927–943.10.1093/schbul/sbn062Search in Google Scholar
Uhlhaas, P.J., Pipa, G., Lima, B., Melloni, L., Neuenschwander, S., Nikolic, D., and Singer, W. (2009). Neural synchrony in cortical networks: history, concept and current status. Front. Integr. Neurosci. 3, 17.10.3389/neuro.07.017.2009Search in Google Scholar
van der Hart, O. and Friedman, B. (1989). A reader(s) guide to Pierre Janet on dissociation: a neglected intellectual heritage. Dissociation 2, 3–16.Search in Google Scholar
van der Meer, L., Costafreda, S., Aleman, A., and David, A.S. (2010). Self-reflection and the brain: a theoretical review and meta-analysis of neuroimaging studies with implications for schizophrenia. Neurosci. Biobehav. Rev. 34, 935–946.10.1016/j.neubiorev.2009.12.004Search in Google Scholar
van der Meer, L., de Vos, A.E., Stiekema, A.P., Pijnenborg, G.H., van Tol, M.J., Nolen, W.A., David, A.S., and Aleman, A. (2013). Insight in schizophrenia: involvement of self-reflection networks? Schizophr. Bull. 39, 1288–1295.10.1093/schbul/sbs122Search in Google Scholar
van Os, J. and Kapur, S. (2009). Schizophrenia. Lancet 374, 635–645.10.1016/S0140-6736(09)60995-8Search in Google Scholar
Varela, F., Lachaux, J.P., Rodriguez, E., and Martinerie, J. (2001). The brainweb: phase synchronization and large-scale integration. Nat. Rev. Neurosci. 2, 229–239.10.1038/35067550Search in Google Scholar
Weiler, M.A., Fleisher, M.H., and McArthur-Campbell, D. (2000). Insight and symptom change in schizophrenia and other disorders. Schizophr. Res. 45, 29–36.10.1016/S0920-9964(99)00215-7Search in Google Scholar
Williams, L.M., Whitford, T. J., Gordon, E., Gomes, L., Brown, K.J., and Harris, A.W. (2009). Neural synchrony in patients with a first episode of schizophrenia: tracking relations with grey matter and symptom profile. J. Psychiatry Neurosci. 34, 21–29.Search in Google Scholar
Woo, T.U., Spencer, K., and McCarley, R.W. (2010). Gamma oscillation deficits and the onset and early progression of schizophrenia. Harv. Rev. Psychiatry 18, 173–189.10.3109/10673221003747609Search in Google Scholar PubMed PubMed Central
Yates, J.L. and Nasby, W. (1993). Dissociation, affect, and network models of memory: an integrative proposal. J. Trauma. Stress 6, 305–326.10.1002/jts.2490060303Search in Google Scholar
©2015 by De Gruyter
Articles in the same Issue
- Frontmatter
- Neural plasticity and memory: molecular mechanism
- Evaluating the functional state of adult-born neurons in the adult dentate gyrus of the hippocampus: from birth to functional integration
- Olfactory mucosa: a rich source of cell therapy for central nervous system repair
- Consciousness, awareness of insight and neural mechanisms of schizophrenia
- Plant-derived natural medicines for the management of depression: an overview of mechanisms of action
- What do patients with epilepsy tell us about language dynamics? A review of fMRI studies
- Genetic associations of leukoaraiosis indicate pathophysiological mechanisms in white matter lesions etiology
- Role of protein kinase A in regulating mitochondrial function and neuronal development: implications to neurodegenerative diseases
Articles in the same Issue
- Frontmatter
- Neural plasticity and memory: molecular mechanism
- Evaluating the functional state of adult-born neurons in the adult dentate gyrus of the hippocampus: from birth to functional integration
- Olfactory mucosa: a rich source of cell therapy for central nervous system repair
- Consciousness, awareness of insight and neural mechanisms of schizophrenia
- Plant-derived natural medicines for the management of depression: an overview of mechanisms of action
- What do patients with epilepsy tell us about language dynamics? A review of fMRI studies
- Genetic associations of leukoaraiosis indicate pathophysiological mechanisms in white matter lesions etiology
- Role of protein kinase A in regulating mitochondrial function and neuronal development: implications to neurodegenerative diseases