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Environmentally responsive hydrogels with dynamically tunable properties as extracellular matrix mimetic

  • Shani Eliyahu-Gross

    Shani Eliyahu-Gross received her MSc in Chemistry from the Weizmann Institute of Science at 2006, focusing on nanotechnology research. She received her PhD from Ben-Gurion University at 2011 under the guidance of Rachel Yerushalmi-Rozen, specializing in ultrathin polymeric-nanoparticle systems at soft interfaces. Shani is currently a postdoctoral scholar in the group of Ronit Bitton at Ben-Gurion University. Her research interests include hydrogels, drug delivery, dynamic self-assembling, and the development of new materials for regenerative medicine.

    and Ronit Bitton

    Ronit Bitton received her BSc in Chemical Engineering in 1997 from the Technion-Israel Institute of Technology. She obtained her MSc (2003) and her PhD (2007) in Biotechnology also from the Technion. After postdoctoral work in the group of Sam Stupp at Northwestern University she joined the department of Chemical Engineering at the Ben-Gurion University of the Negev. She is a member of the Ilse Katz Institute for Nanoscale Science and Technology. Her research focuses on experimental investigation of hierarchical (nano-, micro-) structure and properties of complex materials of interest in regenerative medicine. Materials of interest include hydrogels from polysaccharides and dynamic self-assembling peptides.

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Published/Copyright: May 6, 2013
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Abstract

Hydrogels are hydrophilic polymers with three-dimensional cross-linked structure that swell in aqueous solutions without dissolving in them. Environmentally responsive hydrogels have the ability to change their conformation when a specific stimulus such as temperature, pH, light or enzymes is applied. Such hydrogels have been interesting for biomedical uses as they can deform in situ under physiological conditions and provide the advantage of convenient administration. Over the past decade, hydrogels have been studied as materials for the development of artificial extracellular matrices (ECMs). Recently the ability to utilize external stimuli to mimic the dynamic character of natural ECMs has been explored. The scope of this paper is to review the recent developments in stimuli-responsive hydrogels whose properties can be tuned on the time and length scales of cell development.


Corresponding author: Ronit Bitton, Department of Chemical Engineering, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, Israel

About the authors

Shani Eliyahu-Gross

Shani Eliyahu-Gross received her MSc in Chemistry from the Weizmann Institute of Science at 2006, focusing on nanotechnology research. She received her PhD from Ben-Gurion University at 2011 under the guidance of Rachel Yerushalmi-Rozen, specializing in ultrathin polymeric-nanoparticle systems at soft interfaces. Shani is currently a postdoctoral scholar in the group of Ronit Bitton at Ben-Gurion University. Her research interests include hydrogels, drug delivery, dynamic self-assembling, and the development of new materials for regenerative medicine.

Ronit Bitton

Ronit Bitton received her BSc in Chemical Engineering in 1997 from the Technion-Israel Institute of Technology. She obtained her MSc (2003) and her PhD (2007) in Biotechnology also from the Technion. After postdoctoral work in the group of Sam Stupp at Northwestern University she joined the department of Chemical Engineering at the Ben-Gurion University of the Negev. She is a member of the Ilse Katz Institute for Nanoscale Science and Technology. Her research focuses on experimental investigation of hierarchical (nano-, micro-) structure and properties of complex materials of interest in regenerative medicine. Materials of interest include hydrogels from polysaccharides and dynamic self-assembling peptides.

R.B. gratefully acknowledges the support of The Joseph and May Winston Foundation Career Development Chair in Chemical Engineering.

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Received: 2012-12-12
Accepted: 2013-2-27
Published Online: 2013-05-06
Published in Print: 2013-06-01

©2013 by Walter de Gruyter Berlin Boston

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