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Dipeptidyl peptidase IV: a multifunctional enzyme with implications in several pathologies including cancer

  • Yarini Arrebola Sánchez , Fabiola Almeida García , Daniel Ojeda del Sol , Mario E. Valdés-Tresanco , Carlos David Ortiz , Belinda Sánchez Ramírez and Isel Pascual Alonso EMAIL logo
Published/Copyright: May 11, 2023
Become an author with De Gruyter Brill

Abstract

Ectopeptidases are particularly interesting due to their potential to regulate/dysregulate the peptide mediated signaling cellular pathways because the active site located to the extracellular space. Dipeptidyl peptidase IV (DPP-IV, EC 3.4.14.5) is currently one of the ectopeptidases that has a great and complex influence on important physiological and pathological processes. Due to its influence on the immune system, type 2 diabetes mellitus, pulmonary pathologies, cardiovascular system, viral infections and cancer, DPP-IV is very attractive as a possible therapeutic target. However, its versatility makes such expectations very difficult. The aim of this work is to summarize relevant structural and functional aspects of DPP-IV and the role of this protein in several pathologies with special emphasis on cancer. DPP-IV role in cancer seems to depend on specific location, histologic type of tumour, tumour microenvironment, and presence/absence of molecules able to interact with DPP-IV. Because of DPP-IV controversial effects, generalizations are difficult and most of the time the role of DPP-IV must be analyzed case by case. However, new evidences in cell lines, animal models and clinical studies suggest that DPP-IV inhibitors open a promissory window through new therapeutic strategies against some cancers.


Corresponding author: Isel Pascual, Center for Protein Studies, Faculty of Biology, University of Havana, 25 # 455, between J and I, Plaza de la Revolución, Havana, CP 10 400, Cuba, E-mail:

Funding source: Oficina de Gestión de Fondos y Proyectos Internacionales del Ministerio de Ciencia, TecnologÃ-a y Medio Ambiente de la República de Cuba

Award Identifier / Grant number: PN223LH010-010 2021-2023

Funding source: Ministerio de Ciencia, Tecnología y Medio Ambiente

Award Identifier / Grant number: Unassigned

Acknowledgements

The authors would like to thank the editors for their guidance and review of this article before its publication.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: Results of the group included in the review were partially supported by a University Laboratory in Nanotechnology and Cancer (NaNoCancer) project: “New inhibitors of aminopeptidases with potential applications in cancer” (2016-2022), and a grant from the “Oficina de Gestión de Fondos y Proyectos Internacionales del Ministerio de Ciencia, Tecnología y Medio Ambiente de la República de Cuba” (code PN223LH010-010 2021-2023).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2022-10-30
Accepted: 2023-04-11
Published Online: 2023-05-11

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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