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Synthetic drives for useful drug molecules through organocatalytic methods

  • Bimal Krishna Banik EMAIL logo , Biswa Mohan Sahoo EMAIL logo , Abhishek Tiwari , Varsha Tiwari , Adya Jain and Preetismita Borah
Published/Copyright: February 17, 2022
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Physical Sciences Reviews
From the journal Physical Sciences Reviews Volume 7 Issue 4-5

Abstract

The treatment of various pathological conditions in human beings involves the use of safe and efficacious drug substances. But there are different complications associated with the treatment of various disease states including drug resistance, adverse drug reactions, toxicity, etc. To minimize these problems, there is an urgent need to develop new therapeutics with suitable pharmacokinetic and pharmacodynamic properties. So, the organocatalytic methods are emerged as a potential synthetic tool to accelerate the design of new drug candidates with improved physicochemical and pharmacological properties, selectivity, and efficiency for the treatment of life-threatening diseases. Organocatalytic reactions refer to the chemical reaction that is accelerated by organic catalysts instead of using organometallic catalysts. Organocatalysts are more advantageous in comparison to metallic catalysts because organocatalysts are cost-effective, stable, efficient, non-toxic, readily available, and easy to handle. In addition to this, the organocatalysis method involves an eco-friendly reaction by minimizing the formation of by-products and reducing the chemical hazards. Organocatalysts are categorized into four classes such as Lewis acids, Lewis bases, Bronsted acids, and Bronsted bases. These catalysts are generally involved in various reactions mechanisms such as Aldol reaction, Diels–Alder reactions, Michael Addition and Knoevenagal reactions, etc. The utility of organocatalyst in synthetic chemistry results in the development of medicinally active compounds with diverse structural features.

Keywords: biological activity; drugs; organocatalyst; reaction; synthesis
Corresponding authors: Bimal Krishna Banik, Department of Mathematics and Natural Sciences, College of Sciences and Human Studies, Prince Mohammad Bin Fahd University, Al Khobar, Kingdom of Saudi Arabia, E-mail: ; and Biswa Mohan Sahoo, Roland Institute of Pharmaceutical Sciences, Berhampur 760010, Odisha, India, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

References

1. McMillan, DWC. Commentary the advent and development of organocatalysis. Nature 2008;45:304–8.10.1038/nature07367Search in Google Scholar PubMed

2. Buckley, BR. Organocatalysis. Annu Rep Prog Chem Sect B Org Chem 2008;104:88–105. https://doi.org/10.1039/b716598f.Search in Google Scholar

3. Figueiredo, RM, Christman, M. Organocatalytic synthesis of drugs and bioactive natural products. Eur J Org Chem 2007;16:2575–600. https://doi.org/10.1002/ejoc.200700032.Search in Google Scholar

4. Aleman, J, Cabrera, S. Applications of asymmetric organocatalysis in medicinal chemistry. Chem Soc Rev 2013;42:774–93. https://doi.org/10.1039/c2cs35380f.Search in Google Scholar PubMed

5. Sahoo, BM, Banik, BK. Organocatalysis: trends of drug synthesis in medicinal chemistry. Curr Organocatal 2019;6:92–105. https://doi.org/10.2174/2213337206666190405144423.Search in Google Scholar

6. Feng, B. Total synthesis of natural and pharmaceutical products powered by organocatalytic reactions. Tetrahedron Lett 2015;56:2133–40.10.1016/j.tetlet.2015.03.046Search in Google Scholar

7. Sahoo, BM, Banik, BK. Baker’s yeast-based organocatalysis: applications in organic synthesis. Curr Organocatal 2019;6:158–64. https://doi.org/10.2174/2213337206666181211105304.Search in Google Scholar

8. Gasperi, T, Punzi, P, Migliorini, A, Tofani, D. An Organocatalytic approach to the synthesis of six-membered heterocycles. Curr Org Chem 2011;15:2098–146. https://doi.org/10.2174/138527211796150714.Search in Google Scholar

9. Van der Helm, MP, Klemm, B, Eelkema, R. Organocatalysis in aqueous media. Nat Rev Chem 2019;3:491–508. https://doi.org/10.1038/s41570-019-0116-0.Search in Google Scholar

10. McCort-Tranchepain, I, Petit, M, Dalko, PI. Organocatalysis. Handb Environ Chem 2010;1:255–318. https://doi.org/10.1002/9783527628698.hgc009.Search in Google Scholar

11. Notz, W, Tanaka, F, Barbas, CF3rd. Enamine-based organocatalysis with proline and diamines: the development of direct catalytic asymmetric Aldol, Mannich, Michael, and Diels-Alder reactions. Acc Chem Res 2004;37:580–91. https://doi.org/10.1021/ar0300468.Search in Google Scholar PubMed

12. Raj, M, Singh, VK. Organocatalytic reactions in water. Chem Commun 2009;44:6687–703. https://doi.org/10.1039/b910861k.Search in Google Scholar PubMed

13. Dalko, PI, Moisan, L. In the golden age of organocatalysis. Angew Chem Int Ed Engl 2004;43:5138–75. https://doi.org/10.1002/anie.200400650.Search in Google Scholar PubMed

14. Bensa, D, Constantieux, T, Rodriguez, J. P-BEMP: a new efficient and commercially available user-friendly and recyclable heterogeneous organocatalyst for the Michael Addition of 1,3-dicarbonyl compounds. Synthesis 2004;6:923–7.10.1002/chin.200437080Search in Google Scholar

15. Merino, P, Marques-Lopez, E, Tejero, T, Herrera, RP. Enantioselective organocatalytic Diels-Alder reactions. Synthesis 2010;1:1–26. https://doi.org/10.1055/s-0029-1217130.Search in Google Scholar

16. Ahrendt, KA, Borths, CJ, MacMillan, DWC. New strategies for organic catalysis: the first highly enantioselective organocatalytic Diels-Alder Reaction. J Am Chem Soc 2000;122:4243–4. https://doi.org/10.1021/ja000092s.Search in Google Scholar

17. March, J. Advanced organic chemistry: reactions, mechanisms, and structure, 3rd ed. New York: Wiley–Blackwell; 1985.Search in Google Scholar

18. Jain, K, Chaudhuri, S, Pal, K, Das, K. The Knoevenagel condensation using quinine as an organocatalyst under solvent-free conditions. New J Chem 2019;43:1299–304. https://doi.org/10.1039/C8NJ04219E.Search in Google Scholar

19. Blicke, FF. The Mannich reaction. Org React 2011;1:303–41. https://doi.org/10.1002/0471264180.or001.10.Search in Google Scholar

20. Akiyama, T. Chapter 6.3 C–C Bond Formation: Mannich Reaction. Comprehensive Chirality. 2012;6:69–96. https://doi.org/10.1016/b978-0-08-095167-6.00603-0.Search in Google Scholar

21. Mukhopadhyay, S, Pan, SC. An organocatalytic asymmetric Mannich reaction for the synthesis of 3,3-disubstituted-3,4-dihydro-2-quinolones. Org Biomol Chem 2018;16:5407–11. https://doi.org/10.1039/c8ob01399c.Search in Google Scholar PubMed

22. Mahrwald, R. Modern aldol reactions. Weinheim, Germany: Wiley VCH; 2004:1218–23 pp.10.1002/9783527619566Search in Google Scholar

23. Karaoglu, M, Aydogan, F, Yolacan, C. Pro-phe derivatives as organocatalysts in asymmetric Aldol reaction. Lett Org Chem 2021;18:233–9. https://doi.org/10.2174/1570178617999200517131733.Search in Google Scholar

24. Welch, J. Organic chemistry, synthesis, encyclopedia of physical science and technology, 3rd ed. Academic Press: San Diego; 2003:497–515 pp.10.1016/B0-12-227410-5/00542-1Search in Google Scholar

25. Bartoli, G, Bosco, M, Carlone, A, Locatelli, M, Melchiorre, P, Sambri, L. Organocatalytic asymmetric α-halogenation of 1,3-dicarbonyl compounds. Angew Cheime 2005;44:6219–22. https://doi.org/10.1002/anie.200502134.Search in Google Scholar PubMed

26. Darabi, HR, Aghapoor, K, Farahani, AD, Mohsenzadeh, F. Vitamin B-1 as a metal-free organocatalyst for greener Paal-Knorr pyrrole synthesis. Environ Chem Lett 2012;10:369–75. https://doi.org/10.1007/s10311-012-0361-7.Search in Google Scholar

27. Singh, R, Ganaie, SA, Singh, A. Vitamin B1: a versatile organocatalyst for organic synthesis. Curr Organocatal 2017;4:84–103. https://doi.org/10.2174/2213337204666170824163521.Search in Google Scholar

28. Bhandari, N, Gaonkar, SL. A facile Synthesis of N-substituted 2,5-dimethylpyrroles with saccharin as a green catalyst. Chem Heterocycl Compd 2015;51:320–3. https://doi.org/10.1007/s10593-015-1701-x.Search in Google Scholar

29. Aghapoor, K, Mohsenzadeh, F, Darabi, HR, Sayahi, H, Balavar, Y. Crystalline salicylic acid as an efficient catalyst for ultrafast Paal–Knorr pyrrole synthesis under microwave induction. Res Chem Intermed 2016;42:407–15. https://doi.org/10.1007/s11164-015-2026-1.Search in Google Scholar

30. Azizi, N, Davoudpour, A, Eskandari, F, Batebi, E. Squaric acid catalyzed simple synthesis of N-substituted pyrroles in Green Reaction Media. Monatsh Chem 2013;144:405–9. https://doi.org/10.1007/s00706-012-0841-2.Search in Google Scholar

31. Pawar, HS, Wagh, AS, Lali, AM. Triethylamine: a potential N-base surrogate for pyridine in Knoevenagel condensation of aromatic aldehydes and malonic acid. New J Chem 2016;40:4962–8.10.1039/C5NJ03125GSearch in Google Scholar

32. Abdel-Wahab, BF, Mohamed, HA, Farhat, AA. Ethyl coumarin-3-carboxylate: synthesis and chemical properties. Org Commun 2014;7:1–27.10.1002/chin.201510322Search in Google Scholar

33. Beutler, U, Fuenfschilling, PC, Steinkemper, A. An improved manufacturing process for the antimalaria drug coartem. Part II Org Process Res Dev 2007;11:341–5. https://doi.org/10.1021/op060244p.Search in Google Scholar

34. Wilhelm, EA, Machado, NC, Pedroso, AB, Goldani, BS, Seus, N, Moura, S, . Organocatalytic synthesis and evaluation of 7-chloroquinoline-1,2,3-triazoyl carboxamides as potential antinociceptive, anti-inflammatory and anticonvulsant agent. RSC Adv 2014;4:41437–45. https://doi:10.1039/c4ra07002j.10.1039/C4RA07002JSearch in Google Scholar

35. Madhavachary, R, Mallik, R, Ramachary, DB. Organocatalytic, enantiospecific total synthesis of butenolides. Molecules 2021;26:4320. https://doi.org/10.3390/molecules26144320.Search in Google Scholar PubMed PubMed Central

36. Austin, JF, Kim, S-G, Sinz, CJ, Xiao, W-J, MacMillan, DWC. Enantioselective organocatalytic construction of pyrroloindolines by a cascade addition-cyclization strategy: synthesis of (-)-flustramine B. Proc Natl Acad Sci Unit States Am 2004;101:5482–7. https://doi.org/10.1073/pnas.0308177101.Search in Google Scholar PubMed PubMed Central

37. Ramachary, DB, Ramakumar, K, Narayana, VV. Amino acid-catalyzed cascade [3+2]-cycloaddition/hydrolysis reactions based on the push–pull dienamine platform: synthesis of highly functionalized NH-1,2,3-triazoles. Chem Eur J 2008;14:9143–7. https://doi.org/10.1002/chem.200801325.Search in Google Scholar PubMed

38. Danence, LJT, Gao, Y, Li, M, Huang, Y, Wang, J. Organocatalytic enamide–azide cycloaddition reactions: regiospecific synthesis of 1, 4, 5-trisubstituted-1,2,3-triazoles. Chem Eur J 2011;17:3584–7. https://doi.org/10.1002/chem.201002775.Search in Google Scholar PubMed

39. Shashank, AB, Karthik, S, Madhavachary, R, Ramachary, DB. An enolate-mediated organocatalytic azide–ketone [3+2]-cycloaddition reaction: regioselective high-yielding synthesis of fully decorated 1,2,3-triazoles. Chem Eur J 2014;20:16877–81. https://doi.org/10.1002/chem.201405501.Search in Google Scholar PubMed

40. Saraiva, MT, Krüger, R, Baldinotti, RSM, Lenardão, EJ, Luchese, C, Savegnago, L, et al.. 7-Chloroquinoline-1,2,3-triazoyl carboxylates: organocatalytic synthesis and antioxidant properties. J Braz Chem Soc 2015;27:41–53. https://doi.org/10.5935/0103-5053.20150239.Search in Google Scholar

41. Virk, S, Pansare, SV. Biomimetic organocatalytic approach to 4-arylquinolizidine alkaloids and application in the synthesis of (−)-lasubine II and (+)-subcosine II. Org Lett 2019;21:5524–8. https://doi.org/10.1021/acs.orglett.9b01840.Search in Google Scholar PubMed

42. Yu, L, Ding, Q, Song, C, Junbiao, C. Enantioselective total synthesis of (–)-Angustureine. Chin J Org Chem 2021;41:2507. https://doi.org/10.6023/cjoc202101025.Search in Google Scholar

43. Hoult, JR, Payá, M. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmacol 1996;27:713–22. https://doi.org/10.1016/0306-3623(95)02112-4.Search in Google Scholar

44. Halland, N, Hansen, T, Jorgensen, KA. Organocatalytic asymmetric michael reaction of cyclic 1,3-dicarbonyl compounds and α,β-unsaturated ketones-A highly atom-economic catalytic one-step formation of optically active warfarin anticoagulan. Angew Chem Int Ed 2003;42:4955–7. https://doi.org/10.1002/anie.200352136.Search in Google Scholar PubMed

45. Gujjarappa, R, Vodnala, N, Reddy, VG, Malakar, CC. Niacin as a potent organocatalyst towards the synthesis of quinazolines using nitriles as C-N source. Eur J Org Chem 2020;7:803–14. https://doi.org/10.1002/ejoc.201901651.Search in Google Scholar

46. Chiwunze, TE, Azumah, R, Ramtahal, M, Somboro, AM, Arvidsson, PI, Kruger, HG, et al.. Organocatalyzed Mannich reactions on minocycline: towards novel tetracycline antibiotics. S Afr J Chem 2016;69:72–8. https://doi.org/10.17159/0379-4350/2016/v69a9.Search in Google Scholar

47. Lavilla, R. Recent developments in the chemistry of dihydropyridines. J Chem Soc, Perkin Trans 2002;1:1141–56. https://doi.org/10.1039/b101371h.Search in Google Scholar

48. Shehab, WS, Ghoneim, AA. Synthesis and biological activities of some fused pyran derivatives. Arab J Chem 2016;9:S966–70. https://doi.org/10.1016/j.arabjc.2011.10.008.Search in Google Scholar

49. Pham, H-T, Martin, JP, Le, T-G. Organocatalyzed synthesis and biological activity evaluation of hybrid compounds 4H-pyrano[2,3-b]pyridine derivatives. Synth Commun 2020;50:1–9. https://doi.org/10.1080/00397911.2020.1757717.Search in Google Scholar

50. Vetica, F, Fronert, J, Puttreddy, R, Rissanen, K, Enders, D. Asymmetric organocatalytic synthesis of 4-Aminoisochromanones via a direct one-pot intramolecular Mannich reaction. Synthesis 2016;48:4451–8.10.1055/s-0035-1562522Search in Google Scholar

51. Peng, S, Wang, L, Guo, H, Sun, S, Wang, J. Facile synthesis of 4-substituted 3,4-dihydrocoumarins via an organocatalytic double decarboxylation process. Org Biomol Chem 2012;10:2537. https://doi.org/10.1039/c2ob25075f.Search in Google Scholar PubMed

52. Gomes, CB, Balaguez, RA, Larroza, A, Smaniotto, TA, Domingues, M, Casaril, AM, et al.. Organocatalysis in the synthesis of 1,2,3-Triazoyl-zidovudine derivatives: synthesis and preliminary antioxidant activity. 2020;5:12255–60. https://doi.org/10.1002/slct.202003355.Search in Google Scholar

53. Hoashi, Y, Yabuta, T, Takemoto, Y. Bifunctional thiourea-catalyzed enantioselective double Michael reaction of γ,δ-unsaturated β-ketoester to nitroalkene: asymmetric synthesis of (-)-epibatidine. Tetrahedron Lett 2004;45:9185–8. https://doi.org/10.1016/j.tetlet.2004.10.082.Search in Google Scholar

54. Liu, XD, Deng, LJ, Song, HJ, Jia, HZ, Wang, R. Asymmetric Aza-Mannich addition: synthesis of modified chiral 2-(Ethylthio)-thiazolone derivatives with anticancer potency. Org Lett 2011;13:1494–7. https://doi.org/10.1021/ol200185h.Search in Google Scholar PubMed

55. Brown, LE, Cheng, KC, Wei, W, et al.. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proc Natl Acad Sci USA 2011;108:6775–80.10.1073/pnas.1017666108Search in Google Scholar PubMed PubMed Central

56. Ricci, A. Asymmetric organocatalysis at the service of medicinal chemistry. ISRN Org Chem 2014;16:531695. https://doi.org/10.1155/2014/531695.Search in Google Scholar PubMed PubMed Central

57. Sonsona, IG, Marques-Lopez, E,Gimeno, MC,Herrera, RP. First aromatic amine organocatalysed activation of α, β-unsaturated ketones. New J Chem 2019;43:12233–40. https://doi.org/10.1039/c9nj02392e.Search in Google Scholar

58. Veverková, E, Bilka, S, Baran, R, Šebesta, R. Squaramide-catalyzed Michael addition as a key step for the direct synthesis of GABAergic Drugs. Synthesis 2016;48:1474–82. https://doi.org/10.1055/s-0035-1560420.Search in Google Scholar

59. Dadas, Y, Pelin, G. Synthesis and anticancer activity of some novelTolmetin thiosemicarbazides. Marmara Pharm J 2015;19:259–67.10.12991/mpj.201519328306Search in Google Scholar

60. Dolling, U, Davis, P, Edward, JJ. Efficient catalytic asymmetric alkylations: enantioselective synthesis of (+)-indacrinone via chiralphase-transfer catalysis. J Am Chem Soc 1984;106:446–7. https://doi.org/10.1021/ja00314a045.Search in Google Scholar

61. Zhao, GL, Lin, S, Cordova, A. Asymmetric synthesis of maraviroc (UK-427,857). Adv Synth Catal 2010;13:2291–8. https://doi.org/10.1002/adsc.201000287.Search in Google Scholar

62. Valero, G, Schimer, J, Cisarova, I, Vesely, J, Moyano, A. Highlyenantioselective organocatalytic synthesis of piperidines and formalsynthesis of (-)-Paroxetine. Tetrahedron Lett 2009;50:1943–6. https://doi.org/10.1016/j.tetlet.2009.02.049.Search in Google Scholar

63. Hayashi, Y, Ogasawara, S. Economical total synthesis of (−)-Oseltamivir. Org Lett 2016;18:3426–9. https://doi.org/10.1021/acs.orglett.6b01595.Search in Google Scholar

64. Chouthaiwale, PV, Kotkar, SP, Sudalai, A. Formal synthesis of(-)Anisomycin via organocatalysis. Arkivoc 2009;ii:88–94. https://doi.org/10.3998/ark.5550190.0010.210.Search in Google Scholar

65. Steele, RM, Monti, C, Gennari, C, Piarulli, U, Andreoli, F, Vanthuyne, N, et al.. Enantioselective cyanosilylation of aldehydes catalysed by a diastereomeric mixture of atropisomeric thioureas. Tetrahedron: Asymmetry 2006;17:999–1006. https://doi.org/10.1016/j.tetasy.2006.03.008.Search in Google Scholar

66. Hazra, G, Maity, S, Bhowmick, S, Ghorai, P. Organocatalytic, enantioselective synthesis of benzoxaboroles via Wittig/oxa-Michael reaction cascade of α-formyl boronic acids. Chem Sci 2017;8:3026–30. https://doi.org/10.1039/C6SC04522G.Search in Google Scholar

67. Danishefsky, SJ, Masters, JJ, Young, WB, Link, JT, Snyder, LB, Magee, TV, et al.. Total synthesis of baccatin iii and taxol. 1996;118:2843–59. https://doi.org/10.1021/ja952692a.Search in Google Scholar

68. Meyer, JBO, Helmchen, G. Enantioselective syntheses of (-)-(R)-rolipram, (-)-(R)-baclofen and other GABA analogues via rhodium-catalyzed conjugate addition of arylboronic acids. Synthesis 2003;18:2805–10.10.1055/s-2003-42457Search in Google Scholar

69. Fronza, G, Fuganti, C, Grasselli, P, Mele, A. On the mode of Baker’s yeast transformation of 3–chloropropiophenone and related ketones. Synthesis of (2S)-[2–2H] propiophenone, (R)-fluoxetine, and (R)- and (S)- fenfluramine. J Org Chem 1991;56:6019–23. https://doi.org/10.1021/jo00021a011.Search in Google Scholar

70. Florjańczyk, EB, Kapturowska, AU. Genetically modified Baker’s yeast Saccharomyces cerevisiae in chemical synthesis and biotransformations. Chem Biol 2012:211–34. https://doi.org/10.5772/33079.Search in Google Scholar

71. Pereira, RS. The Use of Baker’s Yeast in the generation of asymmetric centers to Produce chiral drugs and other compounds. Crit Rev Biotechnol 1998;18:25–64. https://doi.org/10.1080/0738-859891224211.Search in Google Scholar

72. Brown, RF, Jackson, WR, McCarthy, TD. A synthesis of (–)-Denopamine. Tetrahedron: Asymmetry 1993;4:2149–50. https://doi.org/10.1016/s0957-4166(00)80062-2.Search in Google Scholar

73. Wang, S, Jiang, Y, Wu, S, Dong, G, Miao, Z, Zhang, W, et al.. Meeting organocatalysis with drug discovery: asymmetric synthesis of 3,3’-spirooxindoles fused with tetrahydrothiopyrans as novel p53-MDM2 inhibitors. Org Lett 2016;18:1028–31. https://doi.org/10.1021/acs.orglett.6b00155.Search in Google Scholar PubMed

74. Fujita, K, Miura, M, Funahashi, Y, Hatanaka, T, Nakamura, S. Enantioselective reaction of 2H-azirines with oxazol-5-(4H)-ones catalyzed by cinchona alkaloid sulfonamide catalysts. Org Lett 2021;23:2104–8. https://doi.org/10.1021/acs.orglett.1c00259.Search in Google Scholar PubMed

75. Rui, P, Xu, Z, Liu, J, Huang, Q. L-Ascorbic acid as an efficient organocatalyst for the synthesis of dispiro[tetrahydroquinoline-bis(1,3-dioxane-4,6-dione)] derivatives. Arkivoc 2021;part vi:1–11.10.24820/ark.5550190.p011.463Search in Google Scholar

76. Vitor, N, Meza, A, Gomes, RS, Rafique, J, Lima, DPD, et al.. Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB. An Acad Bras Cienc 2021;93:1–10. https://doi.org/10.1590/0001-3765202120201347.Search in Google Scholar PubMed

Published Online: 2022-02-17

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Organocatalysis: a green tool for sustainable developments
  4. Reviews
  5. Zwitterionic imidazolium salt: an effective green organocatalyst in synthetic chemistry
  6. The aryl iodine-catalyzed organic transformation via hypervalent iodine species generated in situ
  7. Baker’s yeast (Saccharomyces cerevisiae) catalyzed synthesis of bioactive heterocycles and some stereoselective reactions
  8. Critical trends in synthetic organic chemistry in terms of organocatalysis
  9. Organo-catalysis as emerging tools in organic synthesis: aldol and Michael reactions
  10. Synthetic drives for useful drug molecules through organocatalytic methods
  11. Organocatalytic total synthesis of bioactive compounds based on one-pot methodologies
  12. Organocatalysts based on natural and modified amino acids for asymmetric reactions
  13. Bronsted acidic surfactants: efficient organocatalysts for diverse organic transformations
  14. Microwave-induced biocatalytic reactions toward medicinally important compounds
  15. Sulfonated β-cyclodextrins: efficient supramolecular organocatalysts for diverse organic transformations
  16. Enzyme-catalyzed synthesis of bioactive heterocycles
https://doi.org/10.1515/psr-2021-0024
Keywords for this article
biological activity; drugs; organocatalyst; reaction; synthesis

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Organocatalysis: a green tool for sustainable developments
  4. Reviews
  5. Zwitterionic imidazolium salt: an effective green organocatalyst in synthetic chemistry
  6. The aryl iodine-catalyzed organic transformation via hypervalent iodine species generated in situ
  7. Baker’s yeast (Saccharomyces cerevisiae) catalyzed synthesis of bioactive heterocycles and some stereoselective reactions
  8. Critical trends in synthetic organic chemistry in terms of organocatalysis
  9. Organo-catalysis as emerging tools in organic synthesis: aldol and Michael reactions
  10. Synthetic drives for useful drug molecules through organocatalytic methods
  11. Organocatalytic total synthesis of bioactive compounds based on one-pot methodologies
  12. Organocatalysts based on natural and modified amino acids for asymmetric reactions
  13. Bronsted acidic surfactants: efficient organocatalysts for diverse organic transformations
  14. Microwave-induced biocatalytic reactions toward medicinally important compounds
  15. Sulfonated β-cyclodextrins: efficient supramolecular organocatalysts for diverse organic transformations
  16. Enzyme-catalyzed synthesis of bioactive heterocycles
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