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Photocatalysis with nucleic acids and peptides

  • Arthur Kuhlmann , Sergej Hermann , Michael Weinberger , Alexander Penner and Hans-Achim Wagenknecht EMAIL logo
Published/Copyright: August 11, 2018
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Abstract

In chemical photocatalysis, the photophysical process is coupled to a subsequent chemical reaction. The absorbed light energy contributes to the overall energy balance of the reaction and thereby increases its sustainability. Additionally, oligonucleotides and oligopeptides offer the possibility to control regio- and stereoselectivity as catalysts of organic reactions by providing potential substrate binding sites. We follow this path and want to explore how important substrate binding sites are for photocatalysis. The general concepts of photochemistry and biooligomer catalysis are combined for photochemically active DNAzymes for [2 + 2]-cycloadditions and proline-rich short peptides for nucleophilic additions to styrenes.

Funding statement: This work was financially supported by the Deutsche Forschungsgemeinschaft (Wa 1386/16), the Graduiertenkolleg GRK 1626 (DFG) and KIT.

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Published Online: 2018-08-11

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