Chitosan surface modified PLGA nanoparticles loaded with brigatinib for the treatment of non-small cell lung cancer
-
Muqtader Mohammed
,
Mansour S. Alnafisah
Abstract
In the current study, surface-modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) of brigatinib (BRB) were prepared by studying the variables PLGA (polymer), PVA (stabilizer) and chitosan (coater) against experimentally obtained responses. The optimized NPs (F2) were evaluated in vitro for differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), particle size, polydispersity index (PDI) and drug entrapment (EE), in vitro release, hematocompatibility and in vitro anticancer studies. The optimized NPs’ (F2) composition, PLGA (75 mg), PVA (0.55% w/v), chitosan (0.75% w/v) and 30 mg of BRB was found to be optimum with particle size (406.3 ± 5.1 nm), PDI (0.277), ζ potential (30.4 ± 3.3 mV) and %EE (82.32%). The in vitro release profile showed a sustained release pattern of the F2 nanoparticles of BRB. The 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay revealed a significant anticancer activity for F2 NPs against A549 cell lines in comparison to free BRB. The result obtained in this work indicated the immense potential of nanoparticles to effectively deliver the BRB to the cancer site for the treatment of non-small cell lung cancer.
Acknowledgements
This project was supported by the Deanship of Scientific Research at Prince Sattam Bin Abdulaziz University under the research project no. 2019/03/10912.
Conflict of interest statement: The authors declare no conflict of interests associated with this study.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Material properties
- Characterization and corrosion resistance of ultra-high molecular weight polyethylene composite coatings reinforced with tungsten carbide particles in hydrochloric acid medium
- Tribological properties of PAANa/UHMWPE composite materials in seawater lubrication
- Preparation and assembly
- Acrylic acid-chitosan blend hydrogel: a novel polymer adsorbent for adsorption of lead(II) and copper(II) ions from wastewater
- Efficient preparation of PDMS-based conductive composites using self-designed automatic equipment and an application example
- Significant improvement of the low-temperature toughness of PVC/ASA/NBR ternary blends through the concept of mismatched thermal expansion coefficient
- Chitosan surface modified PLGA nanoparticles loaded with brigatinib for the treatment of non-small cell lung cancer
- Fabrication of polyimide films with imaging quality using a spin-coating method for potential optical applications
- Engineering and processing
- An experimental study on the micro- and nanocellular foaming of polystyrene/poly(methyl methacrylate) blend composites
- Barrel heating with inductive coils in an injection molding machine
- Influence of temperature dependence on the structural characteristics of polyoxymethylene/poly(lactic acid) blends by injection molding
- Annual reviewer acknowledgement
- Reviewer acknowledgement Journal of Polymer Engineering volume 39 (2019)
Articles in the same Issue
- Frontmatter
- Material properties
- Characterization and corrosion resistance of ultra-high molecular weight polyethylene composite coatings reinforced with tungsten carbide particles in hydrochloric acid medium
- Tribological properties of PAANa/UHMWPE composite materials in seawater lubrication
- Preparation and assembly
- Acrylic acid-chitosan blend hydrogel: a novel polymer adsorbent for adsorption of lead(II) and copper(II) ions from wastewater
- Efficient preparation of PDMS-based conductive composites using self-designed automatic equipment and an application example
- Significant improvement of the low-temperature toughness of PVC/ASA/NBR ternary blends through the concept of mismatched thermal expansion coefficient
- Chitosan surface modified PLGA nanoparticles loaded with brigatinib for the treatment of non-small cell lung cancer
- Fabrication of polyimide films with imaging quality using a spin-coating method for potential optical applications
- Engineering and processing
- An experimental study on the micro- and nanocellular foaming of polystyrene/poly(methyl methacrylate) blend composites
- Barrel heating with inductive coils in an injection molding machine
- Influence of temperature dependence on the structural characteristics of polyoxymethylene/poly(lactic acid) blends by injection molding
- Annual reviewer acknowledgement
- Reviewer acknowledgement Journal of Polymer Engineering volume 39 (2019)
