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Synthesis and characterization of a series of novel amino β-cyclodextrin-conjugated poly(ε-lysine) derivatives

  • Rui-Jian Jiang , Bo Yang EMAIL logo , Dong Yi , Fen Wang , Bin Han , Yu-Lin Zhao , Xia-Li Liao , Jian Yang and Chuan-Zhu Gao
Published/Copyright: January 17, 2014
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Abstract

Soluble poly(ε-lysine)s bearing β-cyclodextrin (β-CD) moieties were prepared by three amino β-CD derivatives and N-succinylated poly(ε-lysine), in which the poly(ε-lysine) and amino β-CD derivatives were bonded covalently to the end carboxyl groups of succinic acid by peptide bonds. 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDCI) and N-hydroxysuccinimide (NHS) were chosen to assist the reaction. The three poly(ε-lysine) derivatives were characterized by 1H nuclear magnetic resonance (1H NMR) and Fourier transform infrared (FT-IR). The synthesis process is simple, feasible and has strong practicability. The target polymers can serve as new polymer biomaterial for use in the biotechnology area.


Corresponding author: Bo Yang, Faculty of Life Science and Technology, Department of Pharmaceutical Engineering, Kunming University of Science and Technology, 650500 Kunming, P. R. China, e-mail:

Acknowledgments

This work was supported by the National Natural Science Foundation of China (NNSFC) (No. 21062009) and the Natural Science Foundation of Yunnan Province (No. 2009ZC045M), which are gratefully acknowledged.

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Received: 2013-8-10
Accepted: 2013-12-12
Published Online: 2014-1-17
Published in Print: 2014-4-1

©2014 by Walter de Gruyter Berlin Boston

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