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Layered double hydroxide-supported palladium nanocatalysts in Suzuki-Miyaura coupling: an in-depth review

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Veröffentlicht/Copyright: 17. März 2026
Pure and Applied Chemistry
Aus der Zeitschrift Pure and Applied Chemistry

Abstract

The Suzuki-Miyaura cross-coupling reaction is a popular method for generating carbon-carbon bonds in organic synthesis, especially in medicines, agrochemicals, and materials research. Although palladium-based catalysts are central to this transformation, long-standing challenges such as limited stability, metal leaching, recyclability issues and high catalyst cost continue to motivate the development of improved support materials. Layered double hydroxide (LDH) have recently gained significant attention as functional support material due to their tunable composition, large surface area and intrinsic basicity which collectively promote efficient palladium dispersion and enhance catalytic activity. This review highlights the role of LDH in Suzuki-Miyaura reactions by discussing their synthesis, structural features and influence on catalytic performance. The advantages of LDH-supported palladium catalyst including enhanced stability, reduced Pd leaching and excellent recyclability are examined in detail. Overall, this review offers a comprehensive resource for researchers aiming to design sustainable and high-performance catalytic systems for cross-coupling applications.

Keywords: heterogeneous catalysis; IUPAC2025; layered double hydroxide; palladium catalyst; sustainable chemistry; Suzuki-Miyaura cross-coupling
Corresponding author: Nazrizawati Ahmad Tajuddin, School of Chemistry and Environment, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia, e-mail:
Article note: A collection of articles based on contributions from the 50th IUPAC World Chemistry Congress held from July 14 to 19, 2025, in Kuala Lumpur, Malaysia and organized by the Institut Kimia Malaysia (IKM).

Funding source: MyBrainSc 2023

Funding source: MyPair-ISIS MUON NEUTRON UK Grant

Award Identifier / Grant number: (100-TNCPI/INT 16/6/2(041/2024)

Acknowledgments

The author acknowledges the generous support of University of Technology MARA (UiTM) for this research that was funded through a grant to NAT under MyPair-ISIS MUON NEUTRON UK Grant (100-TNCPI/INT 16/6/2(041/2024)) and MyBrainSc 2023.

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: NAK: Investigation, data curation and writing- original draft. NAT: review and editing. All authors have read and approved the published version of the manuscript.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: No conflict of interest.

  6. Research funding: This research that was funded through a grant to NAT under MyPair-ISIS MUON NEUTRON UK Grant (100-TNCPI/INT 16/6/2(041/2024)) and MyBrainSc 2023.

  7. Data availability: Not applicable.

References

1. Neves, V. A.; Modena, M. L.; Bomfim, J. F.; Aguilera, L. S.; Roco, H. V.; de Campos, J. B.; Carvalho, N. M. F.; Senra, J. D.; Malta, L. F. B. PdNP@Cyclodextrin on Cu/Al LDH-Containing Nanocomposites: Cage Effect, Crystallite Size Tuning and Composite Topology Towards Cross-Couplings. Appl. Clay Sci. 2022, 230, 106702; https://doi.org/10.1016/j.clay.2022.106702.Suche in Google Scholar

2. Ghadiri, A. M.; Farhang, M.; Hassani, P.; Salek, A.; Talesh Ramezani, A.; Akbarzadeh, A. R. Recent Advancements Review Suzuki and Heck Reactions Catalyzed by Metalloporphyrins. Inorg. Chem. Commun. 2023, 149, 110359; https://doi.org/10.1016/j.inoche.2022.110359.Suche in Google Scholar

3. Hooshmand, S. E.; Heidari, B.; Sedghi, R.; Varma, R. S. Recent Advances in the Suzuki-Miyaura Cross-Coupling Reaction Using Efficient Catalysts in Eco-Friendly Media. Green Chem. 2019, 21 (3), 381–405. https://doi.org/10.1039/c8gc02860e.Suche in Google Scholar

4. Sahoo, M.; Parida, K. Noble Metal Loaded ZnCr-LDH Based Hybrid Material for Suzuki Coupling Reactions: A Comparison Study on Heterogeneous Catalysis with Photo Catalysis. Mater. Today: Proc. 2021, 35, 229–232; https://doi.org/10.1016/j.matpr.2020.04.772.Suche in Google Scholar

5. Ghorbani-Vaghei, R.; Sarmast, N.; Rahmatpour, F. Immobilization of Palladium Nanoparticles as a Recyclable Heterogeneous Catalyst for the Suzuki–Miyaura Coupling Reaction’, Comptes Rendus. Chimie 2018, 21 (7), 644–651; https://doi.org/10.1016/j.crci.2018.03.004.Suche in Google Scholar

6. Asadzadeh, F.; Poursattar Marjani, A. Improved One-Pot Synthesis of Suzuki-Miyaura Coupling Using a New Heterogeneous Nanocatalyst Ni Anchored to the Fe3O4@mil-101@-(CH2)3-cl@aa. Inorg. Chem. Commun. 2025, 181, 115211; https://doi.org/10.1016/j.inoche.2025.115211.Suche in Google Scholar

7. Maleki, A.; Taheri-Ledari, R.; Ghalavand, R.; Firouzi-Haji, R. Palladium-Decorated O-Phenylenediamine-Functionalized FE3O4/SiO2 Magnetic Nanoparticles: A Promising Solid-State Catalytic System Used for Suzuki–Miyaura Coupling Reactions. J. Phys. Chem. Solids 2020, 136, 109200; https://doi.org/10.1016/j.jpcs.2019.109200.Suche in Google Scholar

8. Arora, G.; Srivastava, M.; Dwivedi, J.; Jangid, N. K.; Srivastava, A. Microwave-Assisted Synthesis of Biphenyl via Sustainable Suzuki Miyaura Cross-Coupling Reaction Using Mesoporous CS/PVP@Pd. Inorg. Chem. Commun. 2025, 178, 114498; https://doi.org/10.1016/j.inoche.2025.114498.Suche in Google Scholar

9. Tajuddin, N. A.; Sokeri, E. F.; Kamal, N. A.; Dib, M. Fluoride Removal in Drinking Water Using Layered Double Hydroxide Materials: Preparation, Characterization and the Current Perspective on IR4.0 Technologies. J. Environ. Chem. Eng. 2023, 11 (3), 110305; https://doi.org/10.1016/j.jece.2023.110305.Suche in Google Scholar

10. Pan, S.; Hu, B.; Liu, D.; Kuvarega, A. T.; Mamba, B. B.; Gui, J. Fabrication of a Highly Efficient and Reusable Pd/Al2O3/Al Monolithic Catalyst for the Suzuki‐Miyaura Reaction [Preprint]. Eur. J. Org Chem. 2024; https://doi.org/10.1002/ejoc.202400518.Suche in Google Scholar

11. Innocenti, M. D.; Schreiner, T.; Breinbauer, R. Recent Advances in Pd-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions with Triflates or Nonaflates. Adv. Synth. Catal. 2023, 365 (23), 4086–4120; https://doi.org/10.1002/adsc.202301124.Suche in Google Scholar

12. Mai, S.; Li, W.; Li, X.; Zhao, Y.; Song, Q. Palladium-Catalyzed Suzuki-Miyaura Coupling of Thioureas or Thioamides. Nat. Commun. 2019, 10 (1); https://doi.org/10.1038/s41467-019-13701-5.Suche in Google Scholar PubMed PubMed Central

13. Panja, S.; Paul, B.; Mandal, A. Developments in Suzuki-Miyaura Cross Coupling Reaction (SMR) Towards Green Synthesis [Preprint]. 2025; https://doi.org/10.26434/chemrxiv-2025-mf5t7.Suche in Google Scholar

14. Akkoç, S. Importance of Some Factors on the Suzuki-Miyaura Cross-Coupling Reaction. J. Chin. Chem. Soc. 2021 (August 2020), 1–10. https://doi.org/10.1002/jccs.202000351.Suche in Google Scholar

15. Soh, S. K. C.; Jusoh, S. A.; Yusof, M. S. M.; Khairul, W. M.; Shamsuddin, M. The Effect of Bases, Catalyst Loading and Reaction Temperature on the Catalytic Evaluation of Supported Palladium(II) Catalyst in the Mizoroki-Heck. Int. J. Eng. Technol. 2018, 7 (3.7), 467–469.Suche in Google Scholar

16. Farouki, K. E.; Kacem, M.; Dib, M.; Ouchetto, H.; Hafid, A.; Khouili, M. (LDHs)-Based Catalysts for Heterocyclic Synthesis. Current Organocatal. 2024, 11 (2), 154–174; https://doi.org/10.2174/0122133372264682231019101634.Suche in Google Scholar

17. Hosseini-Sarvari, M.; Dehghani, A. Nickel/TiO2-Catalyzed Suzuki–Miyaura Cross-Coupling of Arylboronic Acids with Aryl Halides in MeOH/H2O. Monatshefte für Chemie – Chem. Mon. 2023, 154 (3–4), 397–405; https://doi.org/10.1007/s00706-023-03052-9.Suche in Google Scholar

18. Akhramez, S.; Achour, Y.; Dib, M.; Bahsis, L.; Ouchetto, H.; Hafid, A.; Khouili, M.; El Haddad, M. DFT Study and Synthesis of Novel Bioactive Bispyrazole Using Mg/Al-LDH as a Solid Base Catalyst. Curr. Chem. Biol. 2021, 14 (4), 240–249. https://doi.org/10.2174/2212796814999200918175018.Suche in Google Scholar

19. Dib, M.; Ouchetto, H.; Akhramez, S.; Fadili, H.; Essoumhi, A.; Ouchetto, K.; Hafid, A.; Sajieddine, M.; Khouili, M. Preparation of Mg/Al-LDH Nanomaterials and its Application in the Condensation of 3-Amino-1-Phenyl-2-Pyrazolin-5-One with Aromatic Aldehyde. Mater. Today: Proc. 2020, 22, 104–107. https://doi.org/10.1016/j.matpr.2019.08.106.Suche in Google Scholar

20. Ketike, T.; Velpula, V. R. K.; Madduluri, V. R.; Kamaraju, S. R. R.; Burri, D. R. Carbonylative Suzuki‐Miyaura Cross‐Coupling over PD NPS/Rice‐Husk Carbon‐Silica Solid Catalyst: Effect of 1,4‐dioxane Solvent. ChemistrySelect 2018, 3 (25), 7164–7169; https://doi.org/10.1002/slct.201801100.Suche in Google Scholar

21. Maraval, V.; Hameau, A.; Laurent, R.; Caminade, A. Homogeneous and Heterogeneous Dendrimer-Based Catalysts for CSP2-CSP2 and CSP2-CSP Cross-Coupling Reactions. Coord. Chem. Rev. 2025, 542, 216788; https://doi.org/10.1016/j.ccr.2025.216788.Suche in Google Scholar

22. Swain, S.; Bhavya, M. B.; Kandathil, V.; Bhol, P.; Samal, A. K.; Patil, S. A. Controlled Synthesis of Palladium Nanocubes as an Efficient Nanocatalyst for Suzuki–Miyaura Cross-Coupling and Reduction of p-Nitrophenol. Langmuir 2020, 36 (19), 5208–5218; https://doi.org/10.1021/acs.langmuir.0c00526.Suche in Google Scholar PubMed

23. Munagapati, V. S.; Wen, H. Y.; Wen, J. C.; Lin, K. Y. A.; Gutha, Y.; Gollakota, A. R. K.; Yarramuthi, V.; Rudravarapu, K.; Sangaraju, S.; Choi, H. Y. Biopolymer-Inorganic Hybrid Composites: The Expanding Role of cellulose/layered Double Hydroxides (LDHs) in Advanced Applications. Inorg. Chem. Commun. 2025, 179 (March). https://doi.org/10.1016/j.inoche.2025.114795.Suche in Google Scholar

24. Hahsim, N.; Muda, Z.; Md Isa, I.; Abu Bakar, N.; Wan Mahamod, W. R.; Mohd Ali, N.; Mohd Sharif, S. N.; Jajuli, M. N.; Mohd Zobir, S. A.; Suyanta, S. Synthesis and Application of Zinc Layered Hydroxide: A Short Review. Indones. J. Chem. 2023, 23 (3), 881–898. https://doi.org/10.22146/ijc.82281.Suche in Google Scholar

25. Riadi, Y.; Lazar, S.; Guillaumet, G. Regioselective Palladium-Catalyzed Suzuki–Miyaura Coupling Reaction of 2,4,6-Trihalogenopyrido[2,3-d]Pyrimidines’, Comptes Rendus. Chimie 2019, 22 (4), 294–298; https://doi.org/10.1016/j.crci.2019.01.006.Suche in Google Scholar

26. Huang, Y.; Gao, Y.; Zong, M.; Zong, M. The Influence of ZnO-Modified Biomass Carbon Doping and Supporting Layered Double Hydroxides on Electrochemical Performance [Preprint]. 2025; https://doi.org/10.2139/ssrn.5102583.Suche in Google Scholar

27. Zhang, G.; Zhao, Y.; Zhao, J.; Qin, L.; Li, Y.; Wang, Y.; Tang, Y. NiCoCr-LDH/NiCo2O4 Hierarchical Composites as High-Performance Electrodes for Aqueous Ni-Zn Batteries. Electrochim. Acta 2025, 538, 146987; https://doi.org/10.1016/j.electacta.2025.146987.Suche in Google Scholar

28. Tajuddin, N. A.; Saleh, R.; Manayil, J. C.; Isaacs, M.; Parlett, C. M. A.; Lee, A. F.; Wilson, K. Hydrothermal Reconstructing Routes of Alkali-Free Znal Layered Double Hydroxide: A Characterisation Study. Solid State Phenom. 2019, 290, 168–176; https://doi.org/10.4028/www.scientific.net/ssp.290.168.Suche in Google Scholar

29. Moezzi, A.; Cortie, M. B.; McDonagh, A. M. Zinc Hydroxide Sulphate and its Transformation to Crystalline Zinc Oxide. Dalton Trans. 2013, 42 (40), 14432; https://doi.org/10.1039/c3dt51638e.Suche in Google Scholar PubMed

30. Cui, Z.; Yuan, P.; Li, R.; Tian, B.; Zhang, J.; Sui, X.; Yang, L.; Zhang, T.; Yin, P.; Guan, X. Designed Synthesis of Zeolitic Imidazolate Framework Derived Ag and S Co-Doped Multi-Metal Layered Double Hydroxide for High-Performance Supercapacitors and Zinc Batteries. Electrochim. Acta 2025, 537, 146855; https://doi.org/10.1016/j.electacta.2025.146855.Suche in Google Scholar

31. Contreras-Díaz, C.; Araya-Lopez, C.; Pazo-Carballo, C.; Flores, M.; Diaz, V.; Karelovic, A.; Dongil, A. B.; Escalona, N. Hydrogenation of 4-(2-Furyl)-3-Buten-2-One Using CU-Double Layered Hydroxides Modified with Zr and CE. Appl. Catal., A:Gen. 2025, 704, 120394; https://doi.org/10.1016/j.apcata.2025.120394.Suche in Google Scholar

32. Kalinin, D. V.; Ulven, T. Functional-Group-Tolerant PD-Catalyzed Carbonylative Negishi Coupling with Aryl Iodides. J. Org. Chem. 2023, 88 (23), 16633–16638; https://doi.org/10.1021/acs.joc.3c00948.Suche in Google Scholar PubMed

33. Thirugnanam, B.; Mani, P.; Settu, M.; Venkattappan, A. Unlocking the Potential of Photocatalysts: Recent Advances in Layered Double Hydroxide and Future Outlook. J. Environ. Sci. 2025, 158, 207–227; https://doi.org/10.1016/j.jes.2025.02.040.Suche in Google Scholar PubMed

34. Tekalgne, M. A.; Do, H. H.; Han, G. H.; Hong, S. H.; Cho, J. H.; Ahn, S. H.; Kim, S. Y. Layered Double Hydroxides and metal-Organic Frameworks for Electrocatalytic CO2 Reduction: A Comprehensive Review. Carbon Trends 2024, 16 (June), 100384. https://doi.org/10.1016/j.cartre.2024.100384.Suche in Google Scholar

35. Sun, H.; Xu, C.; Yang, X.; Tao, L.; Wang, Z.; Zhang, H.; Ji, X.; Ma, J.; Liu, L.; Tong, Z.; Chen, Z. Palladium Nanoparticles Supported on LDH: A Highly Efficient and Recyclable Heterogeneous Catalyst for the Heck Reaction. Appl. Clay Sci. 2023, 232, 106765; https://doi.org/10.1016/j.clay.2022.106765.Suche in Google Scholar

36. Kamal, N. A.; Pungot, N. H.; Che Soh, S. K.; Ahmad Tajuddin, N. Facile and Green Hydrothermal Synthesis of MgAl/NiAl/ZnAl Layered Double Hydroxide Nanosheets: A Physiochemical Comparison. Pure Appl. Chem. 2024, 96 (11), 1667–1682; https://doi.org/10.1515/pac-2024-0014.Suche in Google Scholar

37. Yamaguchi, T.; Paek, S. M.; Lee, S. Y.; Oh, J. M. Stabilization of Chemically Flexible Indigo Dye Against Photodegradation Under Solvent Condition Through Intercalation into Layered Double Hydroxide. Appl. Clay Sci. 2025, 272 (April), 107827. https://doi.org/10.1016/j.clay.2025.107827.Suche in Google Scholar

38. Wang, Y.; Xu, Y.; Gao, Z.; Ullah, S.; Li, Y.; Su, N.; Hu, S.; Zhang, X. Stable Bifunctional Nanoflower-Structured NiMnCu-LDH Catalyst for Selective and Efficient Methanol-to-Formate Electrocatalytic Conversion and Hydrogen Evolution Reaction. Int. J. Hydrogen Energy 2025, 158, 150434; https://doi.org/10.1016/j.ijhydene.2025.150434.Suche in Google Scholar

39. Gunawan, M.; Priest, M.; Gunawan, D.; Nie, S.; Satriyatama, A.; Vongsvivut, J.; Hameiri, Z.; Zhang, Q.; Zhou, S.; Amal, R. Differentiating the Role of Ni and Fe in Nifeox Co-Catalyzed BIVO4 Photoanode for Water Oxidation. Energy Environ. Sustain. 2025, 1 (2), 100019; https://doi.org/10.1016/j.eesus.2025.100019.Suche in Google Scholar

40. Liu, D.; Xue, B.; Li, F. Optimization of Hydrothermal Parameters and Multifunctional Catalytic Activity of NiFe-LDH Electrocatalyst. Int. J. Hydrogen Energy 2025, 143 (5988), 44–58. https://doi.org/10.1016/j.ijhydene.2025.05.425.Suche in Google Scholar

41. Hammood, Z. A.; Mohammed, A. A. Understanding the Sorbent Properties of Layered Double Hydroxide for the Removal of Pharmaceuticals from Aqueous Solutions: A Comprehensive Review. Results Chem. 2025, 13, 101952; https://doi.org/10.1016/j.rechem.2024.101952.Suche in Google Scholar

42. Uğur, N.; Onal, H. I.; Ava, C. A.; Aydemir, M.; Durap, F. Palladium(0) Nanoparticles Supported on Benzene Doped Graphitic Carbon Nitride: An Efficient catalyst/photocatalyst for Suzuki-Miyaura C C Coupling Reaction. Mol. Catal. 2025, 585, 115389; https://doi.org/10.1016/j.mcat.2025.115389.Suche in Google Scholar

43. Dib, M.; Kacem, M.; Tajuddin, N. A. Recent Progress in Layered Double Hydroxides-Based Materials as Sustainable Nanoadsorbents for Hazardous Pollutants Recovery from Aqueous Medium. Curr. Mater. Sci. 2025, 18 (1), 76–97; https://doi.org/10.2174/2666145417666230914104249.Suche in Google Scholar

44. Zulkifli, M.; Pungot, N. H.; Tajuddin, N. A.; Aluwi, M. F. F. M.; Jumali, N. S.; Shaameri, Z. A Short Review on the Influence of the Preparation Method on the Physicochemical Properties of Mg/Al Hydrotalcite for Glucose Isomerization. Malays. J. Anal. Sci. 2022, 26 (2), 191–201.Suche in Google Scholar

45. Yuen, O. Y.; Ng, S. S.; Pang, W. H.; So, C. M. Palladium-Catalyzed Chemoselective Suzuki–Miyaura Cross-Coupling Reaction of Poly(Pseudo)Halogenated Arenes. J. Organomet. Chem. 2024, 1005, 122983; https://doi.org/10.1016/j.jorganchem.2023.122983.Suche in Google Scholar

46. Zhang, J.; Li, Z.; Chen, Y.; Gao, S.; Lou, X. W. Nickel–Iron Layered Double Hydroxide Hollow Polyhedrons as a Superior Sulfur Host for Lithium–Sulfur Batteries. Angew. Chem. 2018, 130 (34), 11110–11114; https://doi.org/10.1002/ange.201805972.Suche in Google Scholar

47. Hao, L.; Zhao, J.; Li, K.; Zheng, W.; Yang, Y.; Qiu, C.; Jiang, Z.; Xia, W. Hydrothermal Engineering of Triple-Scale Corrosion Resistance: Structural Barrier, Oxygen Vacancy, and Surface Functionalization in Ce-NiCo-LDH Coatings. J. Colloid Interface Sci. 2025, 698 (May), 137981. https://doi.org/10.1016/j.jcis.2025.137981.Suche in Google Scholar PubMed

48. Van Vaerenbergh, B.; De Vlieger, K.; Claeys, K.; Vanhoutte, G.; De Clercq, J.; Vermeir, P.; Verberckmoes, A. The Effect of the Hydrotalcite Structure and Nanoparticle Size on the Catalytic Performance of Supported Palladium Nanoparticle Catalysts in Suzuki Cross-Coupling. Appl. Catal., A: Gen. 2018, 550 (September 2017), 236–244. https://doi.org/10.1016/j.apcata.2017.11.018.Suche in Google Scholar

49. Tajuddin, N. A.; Manayil, J. C.; Lee, A. F.; Wilson, K. Alkali-Free Hydrothermally Reconstructed NiAl Layered Double Hydroxides for Catalytic Transesterification. Catalysts 2022, 12 (3). https://doi.org/10.3390/catal12030286.Suche in Google Scholar

50. De Tovar, J.; Rataboul, F.; Djakovitch, L. Applied Catalysis A, General Heterogenization of Pd (II) Complexes as Catalysts for the Suzuki-Miyaura Reaction. Appl. Catal. A, Gen. 2021, 627 (October), 118381. https://doi.org/10.1016/j.apcata.2021.118381.Suche in Google Scholar

51. Yue, R.; Zhu, R.; Wang, S.; Li, L.; Zuo, Y.; Chen, J.; Sheng, S. The Role of Ph on Structure, Corrosion Behavior and Biocompatibility of MgFe Layered Double Hydroxide Coating on Mg–Nd–Zn–Zr Alloy. Sci. Rep. 2025, 15 (1), 14842; https://doi.org/10.1038/s41598-025-98555-2.Suche in Google Scholar PubMed PubMed Central

52. Mondal, T.; De, S.; Dutta, S.; Koley, D. Mechanistic Exploration of the Transmetalation and Reductive Elimination Events Involving PdIV–Abnormal NHC Complexes in Suzuki–Miyaura Coupling Reactions: A DFT Study. Chem. – Eur J. 2018, 24 (23), 6155–6168; https://doi.org/10.1002/chem.201800024.Suche in Google Scholar PubMed

53. Duddi, R.; Kumar, S.; Dhiman, S.; Dhiman, S.; Singh, A. K.; Kamboj, N. Hydrothermally Synthesised Porous NiAl-LDH as an Efficient Pseudocapacitive Material in Asymmetric Supercapacitors. Hybrid Adv. 2025, 8 (October 2024), 100372. https://doi.org/10.1016/j.hybadv.2024.100372.ShivaniSuche in Google Scholar

54. Li, J.; Bai, X.; Lv, H. Ultrasonic-Assisted Reduction for Facile Synthesis of Ultrafine Supported Pd Nanocatalysts by Hydroxyl Groups on the Surfaces of Layered Double Hydroxides and Their Catalytic Properties. Ultrason. Sonochem. 2020, 60 (March 2019), 104746. https://doi.org/10.1016/j.ultsonch.2019.104746.Suche in Google Scholar PubMed

55. Zhang, S. Y.; Yu, K.; Guo, Y.; Mou, R.; Lu, X.; Guo, D. Preparation and Reactivation of Heterogeneous Palladium Catalysts and Applications in Sonogashira, Suzuki, and Heck Reactions in Aqueous Media. ChemistryOpen 2018, 7 (10), 803–813; https://doi.org/10.1002/open.201800139.Suche in Google Scholar PubMed PubMed Central

56. Hao, B.; Zhao, J.; Guo, X.; Qu, S.; Li, X. Nano-Au-Decorated Co-LDH Nanocages as Self-Cleaning Flexible SERS Gas Sensor for Label-Free Multiplex Volatile Organic Compounds Detection with Ultrahigh Sensitivity [Preprint]. 2025; https://doi.org/10.2139/ssrn.5263404.Suche in Google Scholar

57. Fukugaichi, S.; Suga, Y.; Noura, S.; Takeyama, K.; Kitamura, K.; Aono, H. Frictional Property of Anionic-Surfactant-Loaded mgal-Layered Double Hydroxide Films on Aluminum Alloy Using a Ring Compression Test. Tribol. Int. 2025, 210, 110810; https://doi.org/10.1016/j.triboint.2025.110810.Suche in Google Scholar

58. Nomicisio, C.; Taviot- Gu’eho, C.; Ruggeri, M.; Forano, C.; Vigani, B.; Viseras, C.; Rossi, S.; Sandri, G. Layered Double Hydroxides for Biomedical Purposes: Sustainable and Green Synthesis. Appl. Clay Sci. 2024, 258, 107480; https://doi.org/10.1016/j.clay.2024.107480.Suche in Google Scholar

59. Hegde, S.; Venkatesan, A.; Nizam, A.; Lakshmaiah, V. V.; Krishna, S. B. N. Transition Metal Infused Magnetic Nanocatalysts for the Synthesis of BIARYLS Through Suzuki-Miyaura Coupling Reaction. Tetrahedron 2025, 185, 134813; https://doi.org/10.1016/j.tet.2025.134813.Suche in Google Scholar

60. Lakshmidevi, J.; Appa, R. M.; Naidu, B. R.; Prasad, S. S.; Sarma, L. S.; Venkateswarlu, K. WEPA: A Bio-Derived Medium for Added Base, π-Acid and Ligand Free Ullmann Coupling of Aryl Halides Using Pd(OAc)2. Chem. Commun. 2018, 54 (87), 12333–12336; https://doi.org/10.1039/c8cc06940a.Suche in Google Scholar PubMed

61. Gao, D.; Zhang, W.; Dong, H.; Yu, Y.; Liu, W.; Luo, H.; Jing, Z.; Liang, B.; Peng, L.; Wu, B.; Huang, T.; Cheng, H. Phosphorus Removal from Water by the Layered Double Hydroxides (LDHs)-Based Adsorbents: A Review for Structure, Mechanism, and Current Progress. Environ. Technol. Innov. 2025, 37 (October 2024). https://doi.org/10.1016/j.eti.2024.104003.Suche in Google Scholar

62. Khairul, W. M.; Wahab, F. F. A.; Soh, S. K. C.; Shamsuddin, M.; Daud, A. I. Palladium(II)-Pivaloyl Thiourea Complexes: Synthesis, Characterisation and Their Catalytic Activity in Mild Sonogashira Cross-Coupling Reaction. Chem. Phys. Lett. 2020, 756, 137842; https://doi.org/10.1016/j.cplett.2020.137842.Suche in Google Scholar

63. Jia, X.; Liu, J.; Zhang, Y.; Jiang, D. Self-Pillared Hierarchical silicalite-1 Zeolites for Enhanced Suzuki-Miyaura Coupling Reactions. Carbon Resour. Convers. 2025, 100331; https://doi.org/10.1016/j.crcon.2025.100331.Suche in Google Scholar

64. D’Alterio, M. C.; Casals‐Cruañas, È.; Tzouras, N. V.; Talarico, G.; Nolan, S. P.; Poater, A. Mechanistic Aspects of the Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reaction. Chem. – Eur. J. 2021, 27 (54), 13481–13493. https://doi.org/10.1002/chem.202101880.Suche in Google Scholar PubMed PubMed Central

65. Nandhini, S.; Mugesh, B.; Butcher, R.; Prabusankar, G.; Karuppuchamy, S.; Prabhakaran, R. Palladium-Catalyzed Suzuki Miyaura Coupling Reaction in Aqueous Ethanol. Inorg. Chim. Acta 2025, 586, 122786; https://doi.org/10.1016/j.ica.2025.122786.Suche in Google Scholar

66. Kanchana, U. S.; Diana, E. J.; Mathew, T. V.; Anilkumar, G. Cyclodextrin Based Palladium Catalysts for Suzuki Reaction: An Overview. Carbohydr. Res. 2020, 489, 107954; https://doi.org/10.1016/j.carres.2020.107954.Suche in Google Scholar PubMed

67. Saki, S.; Khodaei, M. M. Immobilization of CUO NPS on a Highly Nitrogen‐Rich-Modified Metal–Organic Framework, UIO-66-NH2: As an Efficient Heterogeneous Nanocatalyst for the Synthesis of Suzuki–Miyaura Coupling Reaction. Inorg. Chem. Commun. 2025, 176, 114247; https://doi.org/10.1016/j.inoche.2025.114247.Suche in Google Scholar

68. Sheikh, S.; Nasseri, M. A.; Allahresani, A.; Varma, R. S. Copper Adorned Magnetic Nanoparticles as a Heterogeneous Catalyst for Sonogashira Coupling Reaction in Aqueous Media. Sci. Rep. 2022, 12 (1); https://doi.org/10.1038/s41598-022-22567-5.Suche in Google Scholar PubMed PubMed Central

69. Kadu, B. S. Suzuki–Miyaura Cross Coupling Reaction: Recent Advancements in Catalysis and Organic Synthesis. Catal. Sci. Technol. 2021, 11 (4), 1186–1221; https://doi.org/10.1039/d0cy02059a.Suche in Google Scholar

70. Prabhakaran, P. K.; Abidoye, A. K.; Roy, S.; Krishnan, V. V. Layered Double Hydroxides for Sustainable Hydrogen Production from Seawater. Mater. Today Sustain. 2025, 31, 101130; https://doi.org/10.1016/j.mtsust.2025.101130.Suche in Google Scholar

71. Hafiza Ibrahim, E.; Ahmad Tajuddin, N.; Hamzah, N. Synthesis and Characterization of Alkali Free Mg-Al Layered Double Hydroxide for Transesterification of Waste Cooking Oil to Biodiesel: Effect of Mg/Al Ratio. Int. J. Eng. Technol. 2019, 7 (4.14), 154–157; https://doi.org/10.14419/ijet.v7i4.14.27518.Suche in Google Scholar

72. Zhang, Y.; Yin, R. B.; Wei, Y. F.; Fan, Z. Y.; Gao, H. L. Co-Based LDH for High-Performance Supercapacitors: Preparation Methods, Structural Design, and Performance Optimization. Coord. Chem. Rev. 2025, 541 (March), 216804. https://doi.org/10.1016/j.ccr.2025.216804.Suche in Google Scholar

73. Soh, S. K. C.; Yusof, M. S. M.; Khairul, W. M. Unveiling Homogeneous Catalytic Performance of n,n’-Bis-(3,5-Di-Tert-Butylsalicylidene)-2,2-Dimethylpropane-1,3-Diaminepalladium(ii) in the Mizoroki-Heck Reaction. Malays. J. Anal. Sci. 2021, 25 (1), 16–23.Suche in Google Scholar

74. Hong, K.; Sajjadi, M.; Suh, J. M.; Zhang, K.; Nasrollahzadeh, M.; Jang, H. W.; Varma, R. S.; Shokouhimehr, M. Palladium Nanoparticles on Assorted Nanostructured Supports: Applications for Suzuki, Heck, and Sonogashira Cross-Coupling Reactions. ACS Appl. Nano Mater. 2020, 3 (3), 2070–2103. https://doi.org/10.1021/acsanm.9b02017.Suche in Google Scholar

75. Suzuki, A. Carbon–Carbon Bonding Made Easy. Chem. Commun. 2005 (38), 4759; https://doi.org/10.1039/b507375h.Suche in Google Scholar PubMed

76. Alzhrani, G.; Ahmed, N. S.; Aazam, E. S.; Saleh, T. S.; Mokhtar, M. Novel Efficient Pd-Free Ni-Layered Double Hydroxide Catalysts for a Suzuki C–C Coupling Reaction. ChemistrySelect 2019, 4 (27), 7904–7911. https://doi.org/10.1002/slct.201900890.Suche in Google Scholar

77. Kader, D. A.; Sidiq, M. K.; Taher, S. G.; Aziz, D. M. Recent Advances in Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions: Exploration of Catalytic Systems, Reaction Parameters, and Ligand Influences: A Review. J. Organomet. Chem. 2025, 1030, 123569; https://doi.org/10.1016/j.jorganchem.2025.123569.Suche in Google Scholar

78. Zhou, T.; Ji, C.; Hong, X.; Szostak, M. Palladium-Catalyzed Decarbonylative Suzuki–Miyaura Cross-Coupling of Amides by Carbon–Nitrogen Bond Activation. Chem. Sci. 2019, 10 (42), 9865–9871; https://doi.org/10.1039/c9sc03169c.Suche in Google Scholar PubMed PubMed Central

79. Bhattacherjee, D.; Rahman, M.; Ghosh, S.; Bagdi, A. K.; Zyryanov, G. V.; Chupakhin, O. N.; Das, P.; Hajra, A. Advances in Transition-Metal Catalyzed Carbonylative Suzuki-Miyaura Coupling Reaction: An Update. Adv. Synth. Catal. 2021, 363 (6), 1597–1624. https://doi.org/10.1002/adsc.202001509.Suche in Google Scholar

80. Sherstiuk, A.; Lledós, A.; Lönnecke, P.; Hernando, J.; Sebastián, R. M.; Hey-Hawkins, E. Dithienylethene-Based Photoswitchable Phosphines for the Palladium-Catalyzed Stille Coupling Reaction. Inorg. Chem. 2024, 63 (17), 7652–7664; https://doi.org/10.1021/acs.inorgchem.3c04423.Suche in Google Scholar PubMed PubMed Central

81. Beletskaya, I. P.; Alonso, F.; Tyurin, V. The Suzuki-Miyaura Reaction After the Nobel Prize. Coord. Chem. Rev. 2019, 385, 137–173. https://doi.org/10.1016/j.ccr.2019.01.012.Suche in Google Scholar

82. Kacem, M.; Dib, M.; Idrissi Yahyaoui, M.; Boussetta, A.; Jamil, M.; Asehraou, A.; Moubarik, A. A New Technology for Assembling Silylated MgAl-Hydrotalcite with a Protein Derived from Shrimp Waste to Engineer an Innovative Antimicrobial Biocomposite. Inorg. Chem. Commun. 2025a, 173, 113894. https://doi.org/10.1016/j.inoche.2025.113894.Suche in Google Scholar

83. Joshani, Z.; Kakanejadifard, A.; Karmakar, B.; Saremi, S. G.; Veisi, H. Palladium Nanoparticles (Pd NPs) Immobilized over Polydopamine-Functionalized Zn-Al Mixed Metal Oxide as a Novel Nanocatalyst for Synthesis of C-C Bond via Suzuki-Miyaura Coupling Reactions. Inorg. Chem. Commun. 2024, 163 (October 2023). https://doi.org/10.1016/j.inoche.2024.112308.Suche in Google Scholar

84. Çalışkan, M.; Baran, T. Immobilized Palladium Nanoparticles on Schiff Base Functionalized ZnAl Layered Double Hydroxide : A Highly Stable and Retrievable Heterogeneous Nanocatalyst Towards Aryl Halide Cyanations. Appl. Clay Sci. 2022, 219 (February), 106433; https://doi.org/10.1016/j.clay.2022.106433.Suche in Google Scholar

85. Zhu, Y.; Dong, W.; Tang, W. Palladium-Catalyzed Cross-Couplings in the Synthesis of Agrochemicals. Adv. Agrochem. 2022, 1 (2), 125–138; https://doi.org/10.1016/j.aac.2022.11.004.Suche in Google Scholar

86. Heravi, M. M.; Mohammadi, P. Layered Double Hydroxides as Heterogeneous Catalyst Systems in the Cross-Coupling Reactions: An Overview. Mol. Diversity 2022, 26 (1), 569–587. https://doi.org/10.1007/s11030-020-10170-7.Suche in Google Scholar PubMed

87. Bhaskaran, S.; Padusha, M. S. A.; Sajith, A. M. Application of Palladium Based Precatalytic Systems in the Suzuki-Miyaura Cross-Coupling Reactions of Chloro- Heterocycles. ChemistrySelect 2020, 5 (29), 9005–9016. https://doi.org/10.1002/slct.202002357.Suche in Google Scholar

88. Elfarouki, K.; Chhaibi, B.; Aghris, S.; Kacem, M.; Lahrich, S.; El Mhammedi, M. A.; Dib, M.; Hafid, A.; Khouili, M. Electrochemical Sensor Based on CoMgFe-Trimetallic Layered Double Hydroxides for Flubendiamide Detection in Water Samples. J. Electrochem. Soc. 2025, 172 (1), 017515. https://doi.org/10.1149/1945-7111/adaa28.Suche in Google Scholar

89. Rahimi, L.; Mansoori, Y.; Nuri, A.; Koohi‐Zargar, B.; Esquivel, D. A New Pd(II)‐Supported Catalyst on Magnetic SBA‐15 for C-C Bond Formation via the Heck and Hiyama Cross‐Coupling Reactions. Appl. Organomet. Chem. 2020, 35 (2); https://doi.org/10.1002/aoc.6078.Suche in Google Scholar

90. Dragutan, V.; Dragutan, I.; Xiong, G.; You, L.; Sun, Y.; Ding, F. Recent Developments on Carbon-Carbon Cross-Coupling Reactions Using rare-Earth Metals-Derived Coordination Polymers as Efficient and Selective Pd Catalytic Systems. Resour. Chem. Mater. 2022, 1 (3–4), 325–338. https://doi.org/10.1016/j.recm.2022.08.002.Suche in Google Scholar

91. Molaei, S.; Ghadermazi, M. Anchoring of Palladium onto the Surface of Porous MCM-41 Modified with DL-Pyroglutamic Acid as a Novel Heterogeneous Catalyst for Suzuki–Miyaura Coupling Reactions. J. Organomet. Chem. 2021, 953, 122064; https://doi.org/10.1016/j.jorganchem.2021.122064.Suche in Google Scholar

92. Alazemi, A. M.; Dawood, K. M.; Al-Matar, H. M.; Tohamy, W. M. Efficient and Recyclable Solid-Supported Pd(Ii) Catalyst for Microwave-Assisted Suzuki Cross-Coupling in Aqueous Medium. ACS Omega 2022, 7 (33), 28831–28848. https://doi.org/10.1021/acsomega.2c01809.Suche in Google Scholar PubMed PubMed Central

93. Ghasemi, S.; Zare, N.; Ghezelsofloo, M.; Dehghani, A.; Kafshboran, H. R. Thermo-Responsive Poly (N-Isopropyl acrylamide-B-Vinylimidazole)/pd Catalyst: Catalytic Application of Suzuki–Miyaura Coupling Reaction in Water. Catal. Surv. Asia 2025, 29 (2), 139–154; https://doi.org/10.1007/s10563-024-09445-y.Suche in Google Scholar

94. Luo, K.; Zhang, L.; Yang, R.; Jin, Y.; Lin, J. Picolinamide Modified β-Cyclodextrin/pd (II) Complex: Asupramolecular Catalyst for Suzuki-Miyaura Coupling of Aryl, Benzyl and Allyl Halides with Arylboronic Acids in Water. Carbohydr. Polym. 2018, 200, 200–210; https://doi.org/10.1016/j.carbpol.2018.07.089.Suche in Google Scholar PubMed

95. Kantam, M. L.; Subhas, M. S.; Roy, S.; Roy, M. Layered Double Hydroxide-Supported Nanopalladium: An Efficient and Reusable Catalyst for Suzuki Coupling of Aryl Iodides and Bromides at Room Temperature. Synlett 2006 (4), 633–635; https://doi.org/10.1055/s-2006-932478.Suche in Google Scholar

96. Hamedi, F.; Naghipour, A.; Lemraski, E. G.; Taghavi Fardood, S. Synthesis, Characterization and Catalytic Activity in Suzuki-Miura and Mizoroki-Heck Coupling Reactions of Trans-Dichloro bis(4ʹ-Bromobiphenyl-4-Yl)diphenylphosphine Palladium(II) Complex. Int. J. Biol. Chem. 2024, 17 (2), 143–153; https://doi.org/10.26577/ijbch2024v17.i2.11.Suche in Google Scholar

97. Sadati, Z.; Alinezhad, H.; Tajbakhsh, M. Preparation and Characterization of PD Immobilized on the mil-125-NH2 as an Efficient Recyclable Metal-Organic Framework in the Suzuki–Miyaura Reaction. J. Organomet. Chem. 2025, 1025, 123466; https://doi.org/10.1016/j.jorganchem.2024.123466.Suche in Google Scholar

98. Yadav, P. S.; Yadav, N. S.; Jituri, S. D.; Pisal, K. B.; Patil, P. B.; Mali, S. S.; Patil, J. V.; Hong, C. K.; Im, H.; Inamdar, A. I.; Mujawar, S. H. Hydrothermally Synthesized Nickel Cobalt Layered Double Hydroxide for Efficient Oxygen Evolution Reaction and Supercapacitor Applications. J. Phys. Chem. Solids 2025, 206, 112860; https://doi.org/10.1016/j.jpcs.2025.112860.Suche in Google Scholar
Received: 2025-09-30
Accepted: 2025-12-08
Published Online: 2026-03-17

© 2025 IUPAC & De Gruyter

https://doi.org/10.1515/pac-2025-0633
Schlagwörter für diesen Artikel
heterogeneous catalysis; IUPAC2025; layered double hydroxide; palladium catalyst; sustainable chemistry; Suzuki-Miyaura cross-coupling
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