Synthesis of N-formyl dihydropyrazoles as urease inhibitors
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Naveed Iqbal
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Obaid-Ur-Rahman Abid
,
Liaqat Rasheed
Abstract
In this study dihydropyrazole based derivatives were synthesized from substituted chalcone through Michael addition reaction. Urease inhibition activity of the compounds was evaluated, revealing that most compounds exhibited moderate inhibition. Among the synthesized compounds, 2b, 2m, and 2n demonstrated exceptional potency with IC50 values of 5.21 ± 0.91 µM, 6.21 ± 0.10 µM, and 5.21 ± 0.81 µM, respectively. Thus, these findings suggest that dihydropyrazole represent a promising scaffold for the development of novel urease inhibitors.
Funding source: Princess Nourah Bint Abdulrahman University
Award Identifier / Grant number: PNURSP2025R342
Acknowledgments
The authors extend their appreciation to Princess Nourah bint Abdulrahman University researcher supporting project number (PNURSP2025R342), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia for supporting this work.
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Research ethics: Agreed and fulfil the research ethics.
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Informed consent: No consent required.
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Author contributions: W.R.: supervision; MS writing, conceptualization; N.K.: methodology; O.U.R.: data curation, supervision; L.R.: validation, MS editing; M.M.A.: formal analysis, visualization; A.S.A.: formal analysis, data curation.
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Use of Large Language Models, AI and Machine Learning Tools: No tool used.
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Conflict of interest: No conflict of interest.
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Research funding: Researcher supporting project number (PNURSP2025R342), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
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Data availability: The data could be made available, if requested.
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