Home The crystal structure of (E)-4-fluoro-N′-(1-(2-hydroxyphenyl)propylidene)benzohydrazide, C16H15FN2O2
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The crystal structure of (E)-4-fluoro-N′-(1-(2-hydroxyphenyl)propylidene)benzohydrazide, C16H15FN2O2

  • Xiaohua Li , Xin Zhao and Wenqiang Tang ORCID logo EMAIL logo
Published/Copyright: June 20, 2023
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Zeitschrift für Kristallographie - New Crystal Structures
From the journal Zeitschrift für Kristallographie - New Crystal Structures Volume 238 Issue 4

Abstract

C16H15FN2O2, monoclinic, P21/c (no. 14), a = 14.6825(16) Å, b = 11.7155(11) Å, c = 8.8285(7) Å, β = 102.753(10)°, V = 1481.2(2) Å3, Z = 4, Rgt (F) = 0.0670 wRref (F 2) = 0.1669, T = 293 K. 

CCDC no.: 2269167

The crystal structure is shown in the figure. Table 1 contains crystallographic data and Table 2 contains the list of the atoms including atomic coordinates and displacement parameters.

Table 1:

Data collection and handling.

Crystal: Block, colourless
Size: 0.42 × 0.37 × 0.32 mm
Wavelength: Mo Kα radiation (0.71073 Å)
μ: 0.09 mm−1
Diffractometer, scan mode: Bruker SMART, φ and ω-scans
θ max, completeness: 29.3°, >99 %
N(hkl)measured, N(hkl)unique, R int: 6706, 3406, 0.023
Criterion for I obs, N(hkl)gt: I obs > 2σ(I obs), 2188
N(param)refined: 192
Programs: Bruker programs [1], SHELX [2, 3], OLEX2 [4]
Table 2:

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2).

x y z U iso*/U eq
C1 0.4480 (2) 0.9984 (3) 0.2661 (4) 0.0844 (10)
C2 0.4618 (2) 0.8848 (3) 0.2691 (3) 0.0780 (8)
H2 0.504545 0.852190 0.218435 0.094*
C3 0.41068 (17) 0.8176 (2) 0.3494 (3) 0.0601 (6)
H3 0.419211 0.738868 0.352947 0.072*
C4 0.34696 (16) 0.86685 (18) 0.4244 (2) 0.0461 (5)
C5 0.33580 (19) 0.9843 (2) 0.4208 (3) 0.0620 (7)
H5 0.294012 1.018274 0.472369 0.074*
C6 0.3871 (2) 1.0511 (2) 0.3401 (3) 0.0829 (10)
H6 0.380245 1.130049 0.336522 0.099*
C7 0.28993 (16) 0.79810 (18) 0.5108 (2) 0.0445 (5)
C8 0.18331 (15) 0.52828 (18) 0.4896 (2) 0.0439 (5)
C9 0.12743 (15) 0.47227 (18) 0.5878 (2) 0.0432 (5)
C10 0.09510 (18) 0.3603 (2) 0.5589 (3) 0.0595 (7)
H10 0.111027 0.319859 0.477888 0.071*
C11 0.0404 (2) 0.3081 (2) 0.6470 (3) 0.0687 (7)
H11 0.019206 0.233901 0.624211 0.082*
C12 0.01716 (19) 0.3657 (2) 0.7682 (3) 0.0674 (7)
H12 −0.020125 0.330813 0.827265 0.081*
C13 0.04885 (18) 0.4745 (2) 0.8022 (3) 0.0610 (7)
H13 0.034069 0.512496 0.886060 0.073*
C14 0.10263 (15) 0.52878 (19) 0.7134 (2) 0.0460 (5)
C15 0.20053 (19) 0.4696 (2) 0.3468 (3) 0.0615 (7)
H15A 0.148311 0.419619 0.305276 0.074*
H15B 0.203935 0.526534 0.268487 0.074*
C16 0.2884 (3) 0.4013 (4) 0.3793 (5) 0.1219 (14)
H16A 0.294377 0.361643 0.286823 0.183*
H16B 0.286624 0.347045 0.460038 0.183*
H16C 0.340895 0.451337 0.411932 0.183*
F1 0.49699 (16) 1.0654 (2) 0.1871 (3) 0.1378 (9)
N1 0.26706 (12) 0.69130 (14) 0.45606 (18) 0.0430 (4)
H1 0.284732 0.664779 0.376361 0.052*
N2 0.21402 (12) 0.62795 (14) 0.53535 (18) 0.0418 (4)
O1 0.26594 (12) 0.83618 (13) 0.62555 (16) 0.0597 (5)
O2 0.12761 (12) 0.63765 (13) 0.75253 (18) 0.0563 (5)
H2A 0.159798 0.662198 0.694776 0.085*

1 Source of materials

In the experimental procedure, 1 mmol of 4–fluorobenzohydrazide and 1 mmol of 2′-hydroxypropiophenone were added to a 50 mL round-bottom flask containing 25 mL of absolute alcohol and 5 drops of glacial acetic acid. The resulting solution was stirred at 60 °C for 1 h. The mixture was then stirred for an additional 5 h before the solvent was evaporated to a dry state using a rotary evaporator. The crude product was dissolved in a minimal amount of hot ethanol and then slowly cooled to room temperature, resulting in a single crystal.

2 Experimental details

The data were integrated and scaled using the program SAINT [1], and the structure was solved using SHELXT [2]. The final refinement was performed using SHELXL [3] within the Olex2 software package [4]. The hydrogen atoms were placed in calculated positions and refined isotropically using the riding model.

3 Comment

One of the significant research aspects of the N-acylhydrazone moiety is its ability to exhibit diverse pharmacological activities, including anti-inflammatory, anticonvulsant, antiviral, and anticancer properties [5]. Another crucial application of the N-acylhydrazone moiety is its potential as a versatile scaffold for the synthesis of novel small-molecule therapeutics. The determination of single crystal structure for the N-acylhydrazone moiety is significant for understanding their different conformations and orientations that ultimately affect their biological activities [6], [7], [8].

The title molecule adopts an E configuration, which resulted in a long C=N double bond length. As shown in the figure, the bond length of C8=N2 is 1.284(3) Å and the bond length of C7–N1 is 1.357(3) Å. The dihedral angle between the benzene ring and the plane of the hydrazide group is about 15.9°. The bond distances in the crystal structure are standard, and the angles are close to ideal values [9], [10], [11], [12], [13], [14].

The compound also exhibits an intramolecular hydrogen bonding interaction (O2–H2A⃛N2). The bond length is 1.8085(19) Å, and the bond angle is 145.01(12)°. The 2-hydroxyphenyl group and the hydrazide group are in the same plane, and the dihedral angle between these two plane is about 5.7°, which is due to the hydrogen bonding interactions.

Single crystal structure analysis provides a detailed understanding of the molecular arrangement of this compound in a crystal’s lattice, including bond lengths, bond angles, and dihedral angles, similar to reported structures [15], [16], [17], [18], [19].

Corresponding author: Wenqiang Tang, Xianyang Key Laboratory of Molecular Imaging and Drug Synthesis, School of Pharmacy, Shaanxi Institute of International Trade & Commerce, Xianyang, Shaanxi, China, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This work was financially supported by the projects of key research and development project of Shaanxi Provincial Science and Technology Department (2022SF-448), Scientific research plan project of Shaanxi Provincial Department of Education (22JK0276) and the Xianyang key laboratory of molecular imaging and drug synthesis (2021QXNL–PT-0008).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2023-05-09
Accepted: 2023-06-12
Published Online: 2023-06-20
Published in Print: 2023-08-28

© 2023 the author(s), published by De Gruyter, Berlin/Boston

This work is licensed under the Creative Commons Attribution 4.0 International License.

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https://doi.org/10.1515/ncrs-2023-0226
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Articles in the same Issue

  1. Frontmatter
  2. New Crystal Structures
  3. Crystal structure of a polymorph of potassium picrate, C6H2KN3O7
  4. The crystal structure of (1E,2E)-1,2-bis(quinolin-2-ylmethylene)hydrazine, C20H14N4
  5. 5-Amino-2-chloro-4-fluoro-N-(N-isopropyl-N-methylsulfamoyl) benzamide, C11H15O3ClFN3S
  6. Crystal structure of trans-N 1,N 8-bis(2-cyanoethyl)-5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane, C22H42N6
  7. The crystal structure of [N-{[2-(oxy)-4-methoxyphenyl](phenyl)methylidene}alaninato]-diphenyl-silicon(IV) – chloroform (1/1), C29H25NO4Si·CHCl3
  8. Crystal structure of tetracarbonyl-{μ-[N-(diphenylphosphanyl)-N,P,P-triphenylphosphinous amide]}-bis[μ-(phenylmethanethiolato)]diiron (Fe–Fe), C48H39Fe2NO4P2S2
  9. Crystal structure of baryte from Mine du Pradet (France)
  10. The crystal structure of [(2,2′-bipyridine-6-carboxylato-κ3 N,N,O)-(6-phenylpyridine-2-carboxylate-κ2 N,O)copper(II)] monohydrate, C23H17N3O5Cu
  11. Crystal structure of bis(μ-benzeneselenolato)-(μ-[N-benzyl-N-(diphenylphosphanyl)-P,P-diphenylphosphinous amide])-tetracarbonyl diiron (Fe–Fe), C47H37Fe2NO4P2Se2
  12. The crystal structure of diaqua-methanol-κ1 O- (3-thiophenecarboxylato-κO)-(2,2′-dipyridyl-κ2 N,N′)manganese(II) 3-thiophenecarboxylate, C21H22N2O7S2Mn
  13. Crystal structure of catena-poly[tetrakis(butyl)-μ2-2-((oxido(phenyl)methylene)hydrazineylidene)propanoato-κ4 O:O,O′,N-μ2-2-((oxido(phenyl)methylene)hydrazineylidene)propanoato-κ4 O,N,O′:N′-ditin(IV)], C34H50N6O6Sn2
  14. Crystal structure of 4-chloro-N′-[(1E)-(2-nitrophenyl)methylidene]benzohydrazide, C14H10ClN3O3
  15. The crystal structure of 3-(1′-deoxy-3′,5′-O-dibenzy-β-d-ribosyl)adenine dichloromethane solvate, C49H52Cl2N10O6
  16. The crystal structure of (Z)-4-amino-N′-(1-(o-tolyl)ethylidene)benzohydrazide, C16H17N3O
  17. The co-crystal structure of etoricoxib–phthalic acid (1/1), C18H15ClN2O2S·C8H6O4
  18. Crystal structure of (glycinto-κ 2 O,N ′)-[5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane-κ 4 N,N ′,N ″,N ‴]nickel(II) perchlorate monohydrate C18H42ClN5NiO7
  19. The crystal structure of catena-poly[bis(1-ethylimidazole-k1 N)-(μ 2-benzene-1-carboxyl-3,5-dicarboxylato-κ 2 O, O′)zinc(II)], C19H20N4O6Zn
  20. Crystal structure of 3-(thiazol-2-ylcarbamoyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid, C11H12N2O4S
  21. Rietveld structure analysis of keatite, a rare, metastable SiO2 polymorph
  22. Crystal structure of catena-poly[(μ2-isophthalato-k3 O,O′:O″)(4-(4-pyridyl)-2,5-dipyrazylpyridine-k3 N,N′,N″)cobalt(II)] trihydrate C26H22N6O7Co1
  23. Crystal structure of 3,5–di-O-benzoyl-1,2-O-isopropylidene-α–D-ribose, C22H22O7
  24. The crystal structure of fac-tricarbonyl(6-bromo-2,2-bipyridine-κ2 N,N)-(nitrato-κO)rhenium(I), C13H7BrN3O6Re
  25. The crystal structure of (E)-N′-(4-hydroxy-3-methoxybenzylidene)-2-naphthohydrazide monohydrate, C19H18N2O4
  26. The crystal structure of 5,5′-diselanediyl-bis(2-hydroxybenzaldehyde), C14H10O4Se2
  27. The crystal structure of catena-poly[diaqua-m2-dicyanido-κ2 C:N-dicyanido-κ1 C-bis(4-(pyridin-4-yl)benzaldehyde-κ1N)iron(II)-platinum(II), C28H22N6O4PtFe
  28. Redetermination of the crystal structure of 5,14-dihydro-6,17-dimethyl-8,15-diphenyldibenzo(b,i)(1,4,8,11)tetra-azacyclotetradecine, C32H28N4
  29. Crystal structure of poly[(μ3-2-(3,5-dicarboxyphenyl) benzimidazole-6-carboxylato-κ4O:O:O′:O″)lead(II)] monohydrate, C16H10N2O7Pb
  30. The crystal structure of fac-tricarbonyl(2-pyridin-2-yl-quinoline-κ2 N,N′)-(pyrazole-κN)rhenium(I)nitrate, C20H14N4O3ReNO3
  31. Crystal structure of dibromo-dicarbonyl-bis(tricyclohexylphosphine)-osmium(II) dichloromethane solvate, C38H66Br2O2OsP2
  32. Crystal structure of poly[bis(μ 2-2,6-bis(1-imidazoly)pyridine-κ 2 N:N′)copper(II)] diperchlorate dihydrate, C22H22Cl2CuN10O10
  33. The crystal structure of fac-tricarbonyl(N-benzoyl-N,N-cyclohexylmethylcarbamimidothioato-κ2 S,O)-(pyridine-κN)rhenium(I), C23H24N3O4ReS
  34. Crystal structure of (E)-7-fluoro-2-(4-fluorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one, C17H12F2O
  35. Synthesis and crystal structure of 1-((3R,10S,13S, 17S)-3-((2-methoxyphenyl)amino)-10,13-dimethylhexadecahydro-1H-cyclopenta[α]phenanthren-17-yl)ethan-1-one, C28H41NO2
  36. The crystal structure of fac-tricarbonyl((pyridin-2-yl)methanamino-κ2 N,N′)-((pyridin-2-yl)methanamino-κN)rhenium(I) nitrate, C15H16O3N4Re
  37. The crystal structure of (1-(pyridin-2-yl)-N-(pyridin-2-ylmethyl)-N-((1-(4-vinylbenzyl)-1H-benzo[d]imidazol-2-yl)methyl)methanamine-κ 4 N,N′,N″,N‴)tris(nitrato-kO,O′)-erbium(III), C29H27ErN8O9
  38. Crystal structure of tetracene-5,12-dione, C18H10O2
  39. Crystal structure of (3R,3aS,6R,6aR)-6-hexyl-3-methyltetrahydrofuro[3,4-b]furan-2,4-dione, C13H20O4
  40. The crystal structure of N′1,N′3-bis((E)-thiophen-2-ylmethylene)isophthalohydrazide monohydrate, C18H16N4O3S2
  41. Crystal structure of methyl ((4-aminobenzyl)sulfonyl)-L-prolinate, C13H18N2O4S
  42. Crystal structure of (E)-3-(3-methoxybenzylidene)benzofuran-2(3H)-one, C16H12O3
  43. Synthesis and crystal structure (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one, C11H12BrNO2
  44. Synthesis and crystal structure of (S,E)-4-hydroxy-3-(2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylenedecahydro-1H-naphtho[2,1-d][1,3]dioxin-7-yl)ethylidene)dihydrofuran-2(3H)-one, C23H34O5
  45. The crystal structure of N,N′-(1,2-phenylene)bis (2-((2-oxopropyl)selanyl)benzamide), C26H24N2O4Se2
  46. The crystal structure of 1-ethyl-2-nitro-imidazole oxide, C5H7N3O3
  47. The crystal structure of 2-(2-fluorophenyl)naphtho[2,1-d]thiazole, C17H10FNS
  48. Crystal structure of (E)-2,4-di-tert-butyl-6-(((2-fluorophenyl)imino) methyl)phenol, C21H26FNO
  49. Synthesis and crystal structure of 3-methyl-2-(methylthio)-4H-chromen-4-one, C12H12O2S
  50. Crystal structure of dithieno[2,3-d:2′,3′-d′]benzo[1,2-b:4,5-b′]dithiophene-5,10-dione, C14H4O2S4
  51. The crystal structure of dimethyl 2,2ʹ-((adamantane-1,3-diylbis(4,1-phenylene)) bis(oxy))diacetate, C28H32O6
  52. The crystal structure of N-(6-chloro-2-methyl-2H-indazol-5-yl)acetamide, C10H10ClN3O
  53. Crystal structure of triaqua-(5-bromoisophthalato-κ1 O)-(2,2′-bipyridine-κ2 N:N′)nickel(II) hydrate, C18H19BrN2NiO8
  54. The crystal structure of 2-amino-4-carboxypyridin-1-ium perchlorate, C6H7ClN2O6
  55. The crystal structure of catena-poly[5-aminonicotinic acid-k1 N-m2-bromido-copper(I)], Cu(C6N2H6O2)Br
  56. The crystal structure of 2,2-bis(3-methoxyphenyl)-1-tosyl-1,2-dihydro- 2λ4,3λ4  -[1,3,2]diazaborolo[4,5,1-ij]quinoline - dichloromethane (1/1)
  57. The crystal structure of catena-poly[bis(6-phenylpyridine-2-carboxylato-κ2 N,O)-(μ2-4,4′-bipyridne-κ2 N:N)cadmium(II)], C34H24N4O4Cd
  58. The crystal structure of 5,7-dinitropyrazolo[5,1-b]quinazolin-9(4H)-one, C10H5N5O5
  59. Crystal structure of rac-1,8-bis(2-carbamoylethyl)-5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane, C22H46N6O2
  60. The crystal structure of (E)-N ′-(2-bromobenzylidene)-2-naphthohydrazide, C36H26Br2N4O2
  61. The crystal structure of 5-nitronaphthoquinone, C10H5NO4
  62. The crystal structure of (S, R p )-4–benzhydrylideneamino-12-(4-tert-butyl oxazolin-2-yl)[2.2]paracyclophane, C36H36N2O
  63. Synthesis and crystal structure of 2-(2-oxo-2-(o-tolyl)ethyl)-4H-chromen-4-one, C18H14O3
  64. Crystal structure of 2-(thiazol-2-yl)hexahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione, C11H10N2O3S
  65. Crystal structure of N-(diaminomethylene)-1-(dimethylamino)-1-iminiomethanaminium dichloride, C4H13Cl2N5
  66. Crystal structure of poly[(μ3-3, 5-dichloro-2-hydroxy-benzoato-κ4 Cl,O:O′:O″) silver(I)], C7H3AgCl2O3
  67. The crystal structure of tetrakis(1-isopropylimidazole-κ1 N)-[μ2- imidazole-4,5-dicarboxylato-κ4 O,N,O′,N′)]- trioxido-divanadium, C29H41N10O7V2
  68. Crystal structure of catena-[(μ3-bromido)-(1H-1,2,4-triazol-1-yl)benzoato-κ1 N)copper(I)], C9H7BrCuN3O2
  69. The crystal structure of (E)-4-fluoro-N′-(1-(2-hydroxyphenyl)propylidene)benzohydrazide, C16H15FN2O2
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