Home The crystal structure of 2-(7-(2,3-dimethoxyphenyl)-[1,2,4]triazolo[1,5-a]-pyrimidin-5-yl)-3-methoxyphenol, C20H18N4O4
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The crystal structure of 2-(7-(2,3-dimethoxyphenyl)-[1,2,4]triazolo[1,5-a]-pyrimidin-5-yl)-3-methoxyphenol, C20H18N4O4

  • Soon Young Shin and Dongsoo Koh ORCID logo EMAIL logo
Published/Copyright: January 12, 2023
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Zeitschrift für Kristallographie - New Crystal Structures
From the journal Zeitschrift für Kristallographie - New Crystal Structures Volume 238 Issue 2

Abstract

C20H18N4O4, orthorhombic, Pbca (no. 61), a = 7.670(4) Å, b = 15.679(8) Å, c = 29.170(17) Å, V = 3508(3) Å3, Z = 8, Rgt(F) = 0.0497, wRref(F2) = 0.1379, T = 243(2) K.

CCDC no.: 2233773

The molecular structure is shown in the figure. Table 1 contains crystallographic data and Table 2 contains the list of the atoms including atomic coordinates and displacement parameters.

Table 1:

Data collection and handling.

Crystal: Yellow block
Size: 0.18 × 0.12 × 0.09 mm
Wavelength: Mo Kα radiation (0.71073 Å)
μ: 0.10 mm−1
Diffractometer, scan mode: PHOTON III M14, φ and ω
θmax, completeness: 28.3°, >99%
N(hkl)measured, N(hkl)unique, Rint: 74,837, 4372, 0.118
Criterion for Iobs, N(hkl)gt: Iobs > 2 σ(Iobs), 3673
N(param)refined: 257
Programs: Bruker [1], SHELX [2, 3], Olex2 [4]
Table 2:

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2).

Atom x y z Uiso*/Ueq
C1 0.38484 (18) 0.59378 (8) 0.62791 (5) 0.0257 (3)
C2 0.35701 (17) 0.62097 (8) 0.67182 (5) 0.0259 (3)
H2 0.2897 0.6702 0.6768 0.031*
C3 0.42787 (17) 0.57634 (8) 0.71030 (4) 0.0242 (3)
C4 0.54978 (19) 0.47869 (9) 0.66024 (5) 0.0289 (3)
C5 0.6293 (2) 0.41849 (10) 0.60014 (6) 0.0423 (4)
H5 0.6829 0.3785 0.5807 0.051*
C6 0.30267 (18) 0.63133 (9) 0.58661 (5) 0.0266 (3)
C7 0.31347 (18) 0.71865 (9) 0.57803 (5) 0.0268 (3)
C8 0.22543 (18) 0.75381 (9) 0.53996 (5) 0.0285 (3)
C9 0.1308 (2) 0.70083 (10) 0.51126 (5) 0.0359 (3)
H9 0.0719 0.7238 0.4858 0.043*
C10 0.1226 (2) 0.61363 (10) 0.52003 (5) 0.0382 (4)
H10 0.0580 0.5781 0.5004 0.046*
C11 0.2077 (2) 0.57875 (9) 0.55698 (5) 0.0327 (3)
H11 0.2020 0.5197 0.5623 0.039*
C12 0.3499 (4) 0.83560 (11) 0.62957 (7) 0.0630 (6)
H12A 0.3261 0.8832 0.6093 0.095*
H12B 0.4310 0.8535 0.6532 0.095*
H12C 0.2421 0.8167 0.6437 0.095*
C13 0.1568 (3) 0.87668 (11) 0.49522 (6) 0.0429 (4)
H13A 0.1958 0.8500 0.4670 0.064*
H13B 0.1820 0.9373 0.4941 0.064*
H13C 0.0322 0.8683 0.4987 0.064*
C14 0.40307 (17) 0.60166 (8) 0.75868 (4) 0.0250 (3)
C15 0.32199 (18) 0.67928 (9) 0.77281 (5) 0.0282 (3)
C16 0.3013 (2) 0.69961 (10) 0.81890 (5) 0.0374 (3)
H16 0.2484 0.7514 0.8273 0.045*
C17 0.3586 (2) 0.64355 (12) 0.85240 (5) 0.0418 (4)
H17 0.3431 0.6574 0.8835 0.050*
C18 0.4372 (2) 0.56849 (11) 0.84076 (5) 0.0372 (3)
H18 0.4743 0.5308 0.8638 0.045*
C19 0.46275 (19) 0.54748 (9) 0.79470 (5) 0.0298 (3)
C20 0.1802 (2) 0.81018 (10) 0.75238 (6) 0.0398 (4)
H20A 0.0763 0.7959 0.7697 0.060*
H20B 0.1476 0.8421 0.7252 0.060*
H20C 0.2571 0.8446 0.7712 0.060*
N1 0.52069 (16) 0.50528 (7) 0.70339 (4) 0.0280 (3)
N2 0.48650 (16) 0.52257 (7) 0.62295 (4) 0.0276 (3)
N3 0.54005 (19) 0.48372 (8) 0.58320 (4) 0.0378 (3)
N4 0.6406 (2) 0.41137 (8) 0.64611 (5) 0.0388 (3)
O1 0.42467 (16) 0.76693 (7) 0.60383 (4) 0.0388 (3)
O2 0.24599 (15) 0.83905 (6) 0.53345 (4) 0.0351 (3)
O3 0.26813 (15) 0.73349 (6) 0.73912 (4) 0.0349 (3)
O4 0.54735 (16) 0.47357 (7) 0.78714 (4) 0.0390 (3)
H4 0.5643 0.4676 0.7592 0.059*

Source of material

To a solution of 2,3-dimethoxybenzaldehyde (10 mmol, 1.66 g) in 40 ml of ethanol was added 1-(2-hydroxy-6-methoxyphenyl)ethanone (10 mmol, 1.66 g) and the reaction mixture was cooled in an ice-bath. To the reaction mixture was added 10 ml of 40% (w/v) aqueous KOH solution and the reaction mixture was stirred at room temperature for 10 h. At the end of the reaction, ice water was added to the mixture and it was acidified with 6 N HCl (pH = 3–4). The resulting precipitate was filtered and washed with water and ethanol. The crude solid was purified by recrystallization from ethanol to give pure chalcone of (E)-3-(2,3-dimethoxyphenyl)-1-(2-hydroxy-6-methoxyphenyl)prop-2-en-1-one (1.92 g, 61%). An excess amount of 1H-1,2,4-triazol-5-amine (0.84 g, 10 mmol) was added to a solution of the chalcone compound (5 mmol, 1.67 g) in 20 ml DMF, and 1 mL of triethylamine was added to the reaction mixture and was refluxed at 393 K for 15 h. The reaction mixture was cooled to room temperature and was acidified with 3N HCl (pH = 3–4). The resulting precipitate was filtered and washed with ethanol. The crude solid was purified by recrystallization from ethanol to afford the title compound.

Experimental details

Data collections and reduction were carried out using the Bruker software APEX2 and SAINT including Sadabs [1]. Hydrogen atoms were placed in their geometrically idealized positions and constrained to ride on their parent atoms with C–H = 0.96 Å (methyl), Uiso(H) = 1.5 Ueq(C), C–H = 0.94 Å (aromatic), Uiso(H) = 1.2 Ueq(C), O–H = 0.83 Å (hydroxyl), Uiso(H) = 1.5 Ueq(O).

Comment

Triazolo pyrimidine is a heterocycle compound in which a triazole ring and pyrimidine ring are fused. According to a recent review, triazolo pyrimidines have been reported to exhibit various physiological activities [5], and are actively used in drug development [6]. Triazolo pyrimidine is synthesized through the Michael addition reaction of 1,2,4-triazol-5-amine with α,β-unsaturated ketones such as chalcone. Depending on the nitrogens of the triazole used in the reaction, different isomers that cannot be identified by NMR are often formed. In this study, the target compound was obtained by the reaction between 1,2,4-triazol-5-amine and chalcone compound (E)-3-(2,3-dimethoxyphenyl)-1-(2-hydroxy-6-methoxyphenyl)prop-2-en-1-one. There is a possibility that two isomers, 2-(7-(2,3-dimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)-3-methoxyphenol and 2-(5-(2,3-dimethoxyphenyl)-[1,2,4]triazolo[4,3-a]pyrimidin-7-yl)-3-methoxyphenol can be synthesized through this reaction. The two possible isomers are too similar to be distinguished by NMR. The structure of the target compound was clearly confirmed to be 2-(7-(2,3-dimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)-3-methoxyphenol through single crystal X-ray analysis.

The molecular structure of the title compound is shown in the Figure. The central triazolo-pyrimidine fragment (C1–C3/N1/C4/N4/C5/N3/N2) connects the two benzene rings (C6–C11 and C14–C19) at carbon atoms 1 and 3, respectively. The dihedral angle formed by the triazolo-pyrimidine fragment and the C6–C11 benzene ring is 52.5(1)°, which indicates that these two fragments are highly twisted with each other. On the other hand, the dihedral angle between the triazolo-pyrimidine fragment and the C14–C19 benzene ring is 6.97(2)°, indicating that these fragments are close to coplanar. The dihedral angle between the benzene rings is 48.9(3)°. There are three methoxy groups, which are attached to carbon-atom C7 and C8 of the first benzene ring and C15 of the second. The C13 and C20 atoms of the methoxy groups at C8 and C15 are nearly co-planar with their corresponding ring plane by torsion angles C9–C8–O2–C13 = 2.8(2)° and C16–C15–O3–C20 = −3.5(2)°, respectively. The C12 atom of the methoxy group at C7 is rotated significantly from the benzene ring with torsion angle C8–C7–O1–C12 = 66.2(2)°. The hydroxyl group forms an intramolecular O4–H4⃛N1 hydrogen bond with the N1 atom (the H⃛N distance is 1.76 Å, the O–H⃛N angle is 147°) of the triazolo-pyrimidine ring. In the crystal, pairs of C12–H12⃛O4 and C20–H20⃛N4 hydrogen bonds link the molecules into chains propagating along the b-axis direction. Three-dimensional structures of triazolo-pyrimidine compounds with similar structures have recently been reported [7, 8].

Corresponding author: Dongsoo Koh, Department of Applied Chemistry, Dongduk Women’s University, Seoul 02748, Republic of Korea, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: The Korea Drug Development Fundfunded by Ministry of Science and Information and Communication Technologies (ICT), Ministry of Trade, Industry and Energy, and Ministry of Health and Welfare (award No. HN21C0984), Republic of Korea. S. Y. Shin was supported by the KU Research Professor Program of Konkuk University.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

References

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Received: 2022-11-18
Accepted: 2022-11-22
Published Online: 2023-01-12
Published in Print: 2023-04-25

© 2022 the author(s), published by De Gruyter, Berlin/Boston

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  68. The crystal structure of trimethyl 2,2′,2′′-(benzene-1,3,5-triyltris(oxy))triacetate, C15H18O9
  69. Crystal structure of bis(N,N-dimethylformamide-κO)-bis(pyridine-2-carboxylato-κ2N,O)-bis(μ2-pyridine-2-carboxylato-κ2N,O)-dinickel(II), C30H30N6Ni2O10
  70. Crystal structure of bis(μ2-1-pyrenecarboxylato-κ3O,O′:O′)-bis(1-pyrenecarboxylato-κ2O,O′)-(benzimidazole-κ1N)dicadmium(II), C82H48Cd2N4O8
  71. One-pot synthesis and crystal structure of diethyl 2,6-dimethyl-4-(1-(2-nitrophenyl)-1H-1,2,3-triazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate, C21H23N5O6
  72. The crystal structure of 1-(2-fluorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-carbonitrile, C18H13FN2O2
  73. Crystal structure of bis(trimethylphenylammonium) aqua-oxido-octathiotritungstate, (Me3PhN)2[W3OS8(H2O)]
  74. The crystal structure of trichlorido[N-[(2-oxyphenyl)methylidene]phenylglycinemethylester-κ3O,N,O′]-tin(IV) – methylene chloride (1/1), C16H14Cl3NO3Sn·CH2Cl2
  75. The crystal structure of furan-2,5-diylbis((4-chlorophenyl)methanol), C18H14Cl2O3
  76. The crystal structure of hexalithium decavanadate hexadecahydrate, H32Li6O44V10
  77. Crystal structure of ethyl 4-{[5-(adamantan-1-yl)-2-sulfanylidene-2,3-dihydro-1,3,4-oxadiazol-3-yl]methyl}piperazine-1-carboxylate, C20H30N4O3S
  78. Crystal structure of aqua(μ2-2,2′,2″-((nitrilo)tris(ethane-2,1-diyl(nitrilo)methylylidene))tris (6-ethoxyphenolato))(pentane-2,4-dionato-κ2O,O′)-dinickel(II), C38H48N4Ni2O9
https://doi.org/10.1515/ncrs-2022-0534
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Articles in the same Issue

  1. Frontmatter
  2. New Crystal Structures
  3. The crystal structure of methyl 2-((4-chloro-2-fluoro-6-((2,2,2-trifluoroethyl) thio)phenoxy)methyl)benzoate, C17H13ClF4O3S
  4. The crystal structure of 3-hydroxy-5-oxo-4-propanoylcyclohex-3-ene-1-carboxylic monohydrate, C10H14O6
  5. Crystal structure of 2-({[5-(adamantan-2-yl)-2-sulfanylidene-1,3,4-oxadiazolidin-3-yl]methyl}amino)benzonitrile, C20H22N4OS
  6. Crystal structure of 1-(3-bromopropyl)-2-((4-chlorophenoxy)methyl)-4-methyl-1H-benzo[d]imidazole, C18H18BrClN2O
  7. Crystal structure of 2-methoxy-6-[(2-morpholin-4-yl-phenylamino)-methylene]-4-nitro-cyclohexa-2,4-dienone, C18H19N3O5
  8. The crystal structure of 2-(7-(2,3-dimethoxyphenyl)-[1,2,4]triazolo[1,5-a]-pyrimidin-5-yl)-3-methoxyphenol, C20H18N4O4
  9. The crystal structure of 3-(1-(2-(4-hydroxy-3,5-dimethoxybenzylidene)hydrazinyl)ethylidene)chroman-2,4-dione dihydrate, C20H22N2O8
  10. Crystal structure of 3,5,7-trimethoxy-3′,4′-methylenedioxy-flavone, C19H16O7
  11. The crystal structure of strictic acid, C20H26O3
  12. Crystal structure of 1,1′-(pyrazine-1,4-diyl)-bis(propan-2-one), C10H14N2O2
  13. The crystal structure of 1-(adamantan-1-yl)-3-(4-chlorophenyl)urea, C17H21ClN2O
  14. The crystal structure of (2R,6′R)-2′,7-dichloro-4,6-dimethoxy-6′-methyl-3H-spiro[benzofuran-2,1′-cyclohexan]-2′-ene-3,4′-dione, C16H14Cl2O5
  15. Synthesis and crystal structure of 1-((3R,10S,13R,17S)-3-((4-methoxyphenyl)amino)-10,13-dimethylhexadecahydro-1H-cyclopenta[α]-phenanthren-17-yl)ethan-1-one, C28H41NO2
  16. Crystal structure of N-2,6-difluorobenzoyl-N′-[1-(3-chloro-4-methyl-phenyl)-4-cyano-1H-pyrazol-5-carbamoyl]urea, C19H12ClF2N5O2
  17. Crystal structure of (−)-β-D-19-glucopiranosyl-9,15-dihydroxy kaurenoate, C26H40O9
  18. Crystal structure of 7-hydroxy-6-(2-hydroxyethyl)-2H-chromen-2-one, C11H10O4
  19. Crystal structure of S-(benzo[d]thiazol-2-yl)-N-(tert-butyl)thiohydroxylamine, C11H14N2S2
  20. Crystal structure of poly[di-µ2-aqua-aqua-nitrato-κ2O,O′-(µ3-2-nitroisophthalato-κ4O,O′:O″:O′″)barium(II)natrium(II)] monohydrate, C8H11BaN2NaO13
  21. The crystal structure of diaqua-bis(pyrazolo[1,5-a]pyrimidine-3-carboxylato-κ2 N,O)-cobalt(II) dihydrate, C14H16N6O8Co
  22. Crystal structure of (S,E)-3-((pyridin-2-ylmethylene)amino)-2-(pyridin-4-yl)-2,3- dihydroquinazolin-4(1H)-one monohydrate, C19H15N5O⋅H2O
  23. Synthesis and crystal structure of 5-(8-(((5-carboxypentyl)ammonio)methyl)-7-hydroxy-4-oxo-4H-chromen-3-yl)-2-hydroxy-3-nitrobenzenesulfonate monohydrate, C22H24N2O12S
  24. Synthesis and crystal structure of 8-bromo-3-(1H-pyrazole-1-carbonyl)-2H-chromen-2-one, C13H7BrN2O3
  25. Crystal structure of E-7-fluoro-2-(4-methoxy-3-(trifluoromethyl)benzylidene)-3,4-dihydronaphthalen-1(2H)-one, C19H14F4O2
  26. Hydrogen bonded dimers in the crystal structure of 2-chloro-N-((3,5-dimethylphenyl)carbamoyl)-nicotinamide, C30H28Cl2N6O4
  27. Crystal structure of 3,3′-(1,4-phenylenebis(methylene))bis(1-allyl-1H-imidazol-3-ium) bis(hexafluoro phosphate)(V), C10H12F6N2P
  28. Crystal structure of (E)-7-bromo-2-(4-(4-methylpiperazin-1-yl)benzylidene)-3,4-dihydronaphthalen-1(2H)-one, C22H23BrN2O
  29. Crystal structure of pentacarbonyl-(μ2-ethane-1,2-dithiolato-κ4S:S,S′:S′)-(diphenyl(o-tolyl)phosphine-κ1P)diiron (Fe–Fe), C26H21Fe2O5PS2
  30. Crystal structure of 9-(2-chloroethoxy)-4-(4-methoxy-3-(trifluoromethyl)phenyl)- 5,6-dihydrobenzo[h]quinazolin-2-amine, C22H19ClF3N3O2
  31. Crystal structure of triaqua-[5-bromo-2-(carboxylatomethoxy)benzoate-κ3 O,O′,O″]nickel(II), C9H11BrNiO8
  32. The crystal structure of 4,4′-dichloro-3,5′-diphenyl-1′H-1,3′- bipyrazole, C18H12Cl2N4
  33. The crystal structure of bis(1H-pyrazole-carboxamidine-κN,N′)bis(nitrato-κO)-copper(II), C8H12CuN10O6
  34. Synthesis and crystal structure of 3-bromo-4-phenyl-2H-chromene, C15H11BrO
  35. Crystal structure of (E)-5-(diethylamino)-2-((morpholinoimino)methyl)phenol, C15H23N3O2
  36. Crystal structure of niobium trigallide, NbGa3
  37. Crystal structure of dimethyl 4,4′-(((1R, 2R)-cyclohexane-1,2-diyl)bis(azanediyl))dibenzoate, C22H26N2O4
  38. Crystal structure of dimethyl 4,4′-((4R, 5R)-4,5-diphenylimidazolidine-1,3-diyl)dibenzoate, C31H28N2O4
  39. The crystal structure of 2-(2-bromophenyl)-4-phenylbenzo[b][1,4]oxaphosphinine 4-oxide, C20H14BrO2P
  40. The crystal structure of 3-hydroxy-2-nitroestra-1,3,5(10)-trien-17-one, C18H21NO4
  41. Crystal structure of catena-poly[[μ2-1,3-bis[(1H-imidazol-1- yl)methyl]benzene-N:N′]-(μ2–D–camphorato-O, O′: O″, O‴)cadmium(II)], C48H56Cd2N8O8
  42. Crystal structure of N-(4-bromophenyl)-4-[3-(trifluoromethyl)phenyl]-piperazine-1-carbothioamide, C18H17BrF3N3S
  43. The crystal structure of cis-Dicyano-bis(2,2′-bipyridine)k2N,N′-chromium(III) hexafluorophosphate, C22H16N6F6PCr
  44. Crystal structure of 4-((6-bromohexyl)oxy)-2-hydroxybenzaldehyde, C13H17BrO3
  45. Crystal structure of hydrazinium methanesulfonate, CH8N2O3S
  46. Crystal structure of 1-(2-iodobenzoyl)-6-methoxy-1H-indole-3-carbaldehyde, C17H12INO3
  47. Crystal structure of bis(acridinium) tetrabromidomanganate(II), C26H20Br4MnN2
  48. The crystal structure of 6,6′-((1E,1′E)-hydrazine-1,2-diylidenebis(methanylylidene)) bis(2-(tert-butyl)phenol), C22H28N2O2
  49. The crystal structure of the cocrystal di-μ2-chlorido-tetramethyl-tetraphenyl-di-μ3-oxido-dichloridotetratin(IV) – diphenyl-methyl-chloridotin(IV)(1/2), C54H58Cl6O2Sn6
  50. Crystal structure of (3a7R,13bR)-3-((1R)-1-hydroxy-1-(5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-3a,11,11,13b-tetramethyl-2,3,3a,4,5,11,11a,12,13,13b-decahydroindeno[5′,4′:4,5] cyclohepta[1,2-c]oxepin-9(1H)-one, C30H40O5
  51. Crystal structure of 1-(4-methoxyphenyl)-2-phenoxyethan-1-one, C15H14O3
  52. Crystal structure of trans-tetrakis(3-phenylpyridine-κN)bis(thiocyanato-κN)nickel(II), C46H36N6NiS2
  53. Crystal structure of sodium catena-poly[bis(thiourea-κ1S)-tetrakis(μ2-thiourea-κ2S,S)tricopper(I)] difumarate, C14H29Cu3N12NaO8S6
  54. Crystal structure of bis(benzylamine-κ1N)-bis((E)-2-methyl-3-phenylacrylato-κ1O)copper(II), C34H36CuN2O4
  55. The crystal structure of 3,4-dihydroxybenzoic acid – 3-[7-{[2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylsulfanyl)-3H-[1,2,3] triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol – water (1/1/1), C30H36F2N6O9S
  56. Crystal structure of catena-poly[dipyridine-bis(pyridine-2-carboxylato-κ 2 N,O)-bis(μ 2-pyridine-2-carboxylato-κ 2 N,O)-dinickel(II)], C34H26N6Ni2O8
  57. The crystal structure of 1-((1-methyl-1H-1,2,4-triazol-3-yl) methyl)-3-(2,4,5-trifluorobenzyl)-1,3,5-triazinane-2,4,6-trione, C14H11F3N6O3
  58. Crystal structure of (E)-2-((Z)-2-((1S,4R)-3,3-dimethylbicyclo[2.2.1] heptan-2-ylidene)ethylidene)hydrazine-1-carbothioamide, C24H38N6S2
  59. Crystal structure of photochromic 3-(5-(2,5-dimethylthiophen-3-yl)-2,2,3,3,4,4-hexafluorocyclopentyl)-2-methylbenzo[b]-thiophene, C20H14F6S2
  60. Crystal structure of bis(2,5,5,7-tetramethyl-1,4-diazepane-1,4-diium) diaqua-bis(1,2-diaminopropane)copper(II) bis(μ6-oxido)tetrakis(μ3-oxido)-tetradecakis(μ2-oxido)-octaoxido-decavanadium(V) – water (1/4), C24H76CuN8V10O34
  61. Crystal structure of 1,2,3,5,13-pentamethoxy-6,7-dimethyl-1,2,3,4,4a,5,6,7,8,13b-decahydrobenzo[3′,4′]cycloocta[1′,2′:4,5]benzo[1,2-d][1,3]dioxole, C24H30O7
  62. Crystal structure of bis(6-carboxyhexyl)-4,4′-bipyridinium dibromide – 2,6-dihydroxynaphthalene (1/2), C42H46Br2N2O8
  63. Crystal structure of methyl 2-(2-chloroacetyl)-1-(4-(methoxycarbonyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b] indole-3-carboxylate, C23H21ClN2O5
  64. Crystal structure of bis(dimethylammonium) poly[{μ4-1,1ʹ-(1,4-phenylenebis(methylene))bis(1H-pyrazole-3,5-dicarboxylato)-κ6N4O2}zinc(II)], C22H26N6O8Zn
  65. Crystal structure of 2-(2-(4-methoxyphenyl)-2H-indazol-3-yl)acetonitrile, C16H13N3O
  66. Crystal structure of (E)-7-methoxy-2-(4-morpholinobenzylidene)-3,4-dihydronaphthalen-1(2H)-one, C22H23NO3
  67. The crystal structure of N′1,N′2-bis((E)-3-(tert-butyl)-2-hydroxybenzylidene)oxalohydrazide, C24H30N4O4
  68. The crystal structure of trimethyl 2,2′,2′′-(benzene-1,3,5-triyltris(oxy))triacetate, C15H18O9
  69. Crystal structure of bis(N,N-dimethylformamide-κO)-bis(pyridine-2-carboxylato-κ2N,O)-bis(μ2-pyridine-2-carboxylato-κ2N,O)-dinickel(II), C30H30N6Ni2O10
  70. Crystal structure of bis(μ2-1-pyrenecarboxylato-κ3O,O′:O′)-bis(1-pyrenecarboxylato-κ2O,O′)-(benzimidazole-κ1N)dicadmium(II), C82H48Cd2N4O8
  71. One-pot synthesis and crystal structure of diethyl 2,6-dimethyl-4-(1-(2-nitrophenyl)-1H-1,2,3-triazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate, C21H23N5O6
  72. The crystal structure of 1-(2-fluorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-carbonitrile, C18H13FN2O2
  73. Crystal structure of bis(trimethylphenylammonium) aqua-oxido-octathiotritungstate, (Me3PhN)2[W3OS8(H2O)]
  74. The crystal structure of trichlorido[N-[(2-oxyphenyl)methylidene]phenylglycinemethylester-κ3O,N,O′]-tin(IV) – methylene chloride (1/1), C16H14Cl3NO3Sn·CH2Cl2
  75. The crystal structure of furan-2,5-diylbis((4-chlorophenyl)methanol), C18H14Cl2O3
  76. The crystal structure of hexalithium decavanadate hexadecahydrate, H32Li6O44V10
  77. Crystal structure of ethyl 4-{[5-(adamantan-1-yl)-2-sulfanylidene-2,3-dihydro-1,3,4-oxadiazol-3-yl]methyl}piperazine-1-carboxylate, C20H30N4O3S
  78. Crystal structure of aqua(μ2-2,2′,2″-((nitrilo)tris(ethane-2,1-diyl(nitrilo)methylylidene))tris (6-ethoxyphenolato))(pentane-2,4-dionato-κ2O,O′)-dinickel(II), C38H48N4Ni2O9
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