Do uterotrophic drugs increase the risk of fatal hemorrhagic brain stroke?
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Takashi Yamada
,
Takahiro Yamada
Abstract
Objective: To evaluate whether uterotrophic agents increase the risk of fatal hemorrhagic brain stroke.
Methods: Between 1991 and 1992, there were 230 maternal deaths among 2,420,000 pregnant women in Japan and the causes of these deaths was investigated in 1994. Using information provided in this report, we identified 35 women who died from or were assumed to die from hemorrhagic brain stroke. We assumed that 93% of women would have tried vaginal delivery. The risk of fatal hemorrhagic brain stroke after uterotrophic agent use was calculated according to the assumption that 5.0–40% of women received uterotrophic agents.
Results: Use of uterotrophic agents for induction/augmentation of labor was confirmed in five (14.3%) of the 35 women who died from hemorrhagic brain stroke. The incidence of fatal brain stroke after the use of uterotrophic agents was only significantly higher than that for spontaneous hemorrhagic brain stroke if these agents were administered in ≤6.0% of women.
Conclusions: Because more than 6.0% of women received uterotrophic agents, these agents are unlikely to increase the risk of fatal hemorrhagic brain stroke.
©2011 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Publisher's note
- Publisher's Note
- Review articles
- 3D and 4D sonography and magnetic resonance in the assessment of normal and abnormal CNS development: alternative or complementary
- Selective reduction in twins and multiple pregnancies
- Original articles – Obstetrics
- Do uterotrophic drugs increase the risk of fatal hemorrhagic brain stroke?
- Parental factors affecting the weights of the placenta and the offspring
- Trends in maternal mortality due to obstetric hemorrhage in urban and rural China, 1996–2005
- Original articles – Fetus
- Abdominal circumference ratio for the diagnosis of intertwin birth weight discordance
- Predicting survival of periviable fetuses using NICHD fetal heart rate categories
- Prospective risk of stillbirth in monochorionic-diamniotic twin gestations: a population based study
- Original articles – Newborn
- Effect of ibuprofen on bilirubin-albumin binding affinity in premature infants
- Evaluation and clinical application of changes in thyroid hormone and TSH levels in critically ill full-term newborns
- NCI classification of thrombocytopenia in extremely preterm neonates and its association with mortality and morbidity
- Epidemiology of congenital syphilis in a South Bronx population: a follow-up study
- Quantitative ultramicrotest for newborn screening of galactosemia in Cuba
- Expression of soluble Fas in the cerebrospinal fluid of preterm infants with posthemorrhagic hydrocephalus and cystic white matter damage
- Early left ventricular diastolic dysfunction in premature infants born to preeclamptic mothers
- Letter to the Editors
- Perimortem instrumental vaginal delivery
- Human sex ratio at birth and related factors
- Twins are a risk factor for developing severe hypertensive disorders in the puerperium following a normotensive pregnancy
- Congress calendar
- Congress Calendar
