Early protective effect of hypothermia in newborn pigs after hyperoxic, but not after normoxic, reoxygenation
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Marit L. Dalen
Abstract
Mild hypothermia can attenuate the development of brain damage after asphyxia. Supplemental oxygen during resuscitation increases generation of reactive oxygen species, compared to room air. It is unknown if supplemental oxygen affects hypothermic neuroprotection. We studied the early effects of hyperoxic reoxygenation and subsequent hypothermia on tissue oxygenation, microcirculation, inflammation and brain damage after global hypoxia. Anesthetized newborn pigs were randomized to control (n=6), or severe global hypoxia (n=46). Three pigs died during hypoxia or reoxygenation. After 20-min reoxygenation with room air (n=22) or 100% oxygen (n=21), pigs were randomized to normothermia (deep rectal temperature 39°C, n=22) or total body cooling (35°C, n=21) for 6.5 h before the experiment was terminated. We demonstrated a differential effect of post-hypoxic hypothermia between animals reoxygenated with 100% oxygen and with room air, with reduced damage only in hypothermic animals reoxygenated with 100% oxygen (P=0.001). Hyperoxic reoxygenation resulted in a significant overshoot in striatal oxygen tension, without affecting microcirculation. Inflammatory response after the insult did not differ between groups. The results indicate an early protective effect of hypothermia which may vary with oxygen level used during reoxygenation.
©2010 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Review article
- Monochorionic twin pregnancy: screening, pathogenesis of complications and management in the era of microinvasive fetal surgery
- Original articles – Obstetrics
- Longitudinal examination of cervical volume and vascularization changes during the antepartum and postpartum period using three-dimensional and power Doppler ultrasound
- Uterine and umbilical artery Doppler velocimetry as a predictor for adverse pregnancy outcomes in pregnant women with anemia
- Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation
- Two-stage transvaginal cervical length screening for preterm birth in twin pregnancies
- The relationship between placental histology and cervical length in twin gestations
- A novel method for evaluating uterine cervical consistency using vaginal ultrasound gray-level histogram
- Microbial invasion of the amniotic cavity in pregnancies with small-for-gestational-age fetuses
- Microbial invasion of the amniotic cavity in preeclampsia as assessed by cultivation and sequence-based methods
- Original articles – Fetus
- Perinatal exposure to di-(2-ethylhexyl) phthalate leads to restricted growth and delayed lung maturation in newborn rats
- Calprotectin in human cord blood: relation to perinatal parameters and restricted fetal growth
- Original articles – Newborn
- Diagnostic value of interleukin-6 and C-reactive protein on early onset bacterial infection in preterm neonates with respiratory distress
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- Letter to the editor
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- Congress Calender
- Congress Calendar
