Antenatal steroid treatment reduces childhood asthma risk in very low birth weight infants without bronchopulmonary dysplasia
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Yi-Li Hung
Abstract
Bronchopulmonary dysplasia (BPD) and very low birth weight (VLBW) are associated with increased incidences of asthma and pulmonary dysfunction in childhood. However, no studies exist which examine asthma risk factors in children who were VLBW infants and did not have BPD. To address this issue, we assessed the asthma incidence and risk factors for asthma in 117 children (approximate mean age of 5 years) who were VLBW [<1500 g, mean gestational age (GA): 30 weeks] infants without BPD. The risk factors were both perinatal (such as steroid treatment, mechanical ventilation, surfactant treatment) and environmental (parental smoking, pet adoption, etc). The asthma incidence was 18.8%. Following multivariate analysis, it was determined that a family history of atopy was a strong risk factor for childhood asthma. Maternal antenatal steroid treatment was associated with a significantly reduced risk for asthma. GA and birth weight were not predictive of childhood asthma. These findings indicate that a history of familial atopy and antenatal steroid treatment are positively and negatively associated (independent of BPD) with childhood asthma in VLBW infants. The finding regarding antenatal steroid treatment warrants more extensive investigations.
©2010 by Walter de Gruyter Berlin New York
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- Roster of Perinatal Societies
- Roster of Perinatal Societies
- Congress Calendar
- Congress Calendar
Articles in the same Issue
- The Declaration of Dubrovnik
- The prediction and prevention of preterm birth and its consequences: an unmet challenge to perinatal medicine, science and society
- Original articles – Obstetrics
- Women's attitudes to and perceptions of oral health and dental care during pregnancy
- Low circulating maternal adiponectin in patients with pyelonephritis: adiponectin at the crossroads of pregnancy and infection
- Improving obstetric estimation of outcomes of extremely premature neonates: an evolving challenge
- Atosiban vs. ritodrine as a tocolytic in external cephalic version at term: a prospective cohort study
- Evaluation of placental function using near infrared spectroscopy during fetal growth restriction
- Association between women's self-diagnosis of labor and labor duration after admission
- Amniotic fluid volume in intra-amniotic inflammation with and without culture-proven amniotic fluid infection in preterm premature rupture of membranes
- The prognosis of pregnancy conceived despite the presence of an intrauterine device (IUD)
- Takayasu's arteritis in pregnancy: review of literature and discussion
- Role of parental folate pathway single nucleotide polymorphisms in altering the susceptibility to neural tube defects in South India
- Original articles – Fetus
- Cholinergic signal activated renin angiotensin system associated with cardiovascular changes in the ovine fetus
- The potential of 4D sonography in the assessment of fetal neurobehavior – multicentric study in high-risk pregnancies
- Predictive value of pulse oximetry for the development of fetal acidosis
- Racial/ethnic disparities in infant mortality
- Original articles – Newborn
- Antenatal steroid treatment reduces childhood asthma risk in very low birth weight infants without bronchopulmonary dysplasia
- Roster of Perinatal Societies
- Roster of Perinatal Societies
- Congress Calendar
- Congress Calendar
