Is forty the new thirty? Population based study of advanced maternal age
-
Gabrijela Brzan Simenc
,
Ivan Verdenik
Abstract
Objective:
To compare perinatal outcomes in different advanced maternal age groups.
Patients and methods:
We used a population-based data set to compare perinatal outcomes in three maternal age groups: 30–34.9, 35–39.9, and in women over 40 years.
Results:
Over a 10-year period there were 23,422 (25.2%) births in the 35–39.9 years group, 3987 (4.3%) in the over 40 years group, and 65,492 births (70.5%) in our reference group (30–34.9 years). A direct significant relationship was found between maternal age and BMI and between pregnancy complications such as diabetes and hypertensive disorders, whereas an inverse relationship was found between older age and nuliparity and spontaneous conceptions. Also, older mothers had a higher incidence of both types of cesareans, and more early as well as late preterm births. Perinatal mortality was similar in all groups.
Conclusions:
Advanced maternal age is associated with higher, gradually increasing, incidence, of adverse perinatal outcomes.
Author’s statement
Conflict of interest: Authors state no conflict of interest.
Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.
Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.
References
[1] Blickstein I. Motherhood at or beyond the edge of reproductive age. Int J Fertil Womens Med. 2003;48:17–24.Search in Google Scholar
[2] National Vital Statistics Reports, Vol. 64, No. 6, June 17, 2015.Search in Google Scholar
[3] Khalil A, Syngelaki A, Maiz N, Zinevich Y, Nicolaides KH. Maternal age and adverse pregnancy outcome: a cohort study. Ultrasound Obstet Gynecol. 2013;42:634–43.10.1097/OGX.0000000000000018Search in Google Scholar
[4] Salem Yaniv S, Levy A, Wiznitzer A, Holcberg G, Mazor M, Sheiner E. A significant linear association exists between advanced maternal age and adverse perinatal outcome. Arch Gynecol Obstet. 2011;283:755–9.10.1007/s00404-010-1459-4Search in Google Scholar PubMed
[5] Delbaere I, Verstraelen H, Goetgeluk S, Martens G, De Backer G, Temmerman M. Pregnancy outcome in primiparae of advanced maternal age. Eur J Obstet Gynecol Reprod Biol. 2007;135:41–6.10.1016/j.ejogrb.2006.10.030Search in Google Scholar PubMed
[6] Jacobsson B, Ladfors L, Milsom I. Advanced maternal age and adverse perinatal outcome. Obstet Gynecol. 2004;104:727–33.10.1097/01.AOG.0000140682.63746.beSearch in Google Scholar PubMed
[7] American College of Obstetricians and Gynecologists. Weight gain during pregnancy. Committee Opinion No. 548. Obstet Gynecol. 2013;121:210–2.10.1097/01.AOG.0000425668.87506.4cSearch in Google Scholar
[8] International Association of Diabetes and Pregnancy Study Groups Consensus Panel. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010;33:676–82.10.2337/dc09-1848Search in Google Scholar PubMed PubMed Central
[9] The World Health Organization guideline. Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy. Available at: http://apps.who.int/iris/bitstream/10665/85975/1/WHO_NMH_MND_13.2_eng.pdf?ua=1%2520%2520. Accessed Nov 20 2016.Search in Google Scholar
[10] Cakmak Celik F, Aygun C, Kucukoduk S, Bek Y. Maternal and neonatal outcomes in advanced maternal age: a retrospective cohort study. J Matern Fetal Neonatal Med. 2016;22:1–5.10.1080/14767058.2016.1253058Search in Google Scholar PubMed
[11] Klemetti R, Gissler M, Sainio S, Hemminki E. At what age does the risk for adverse maternal and infant outcomes increase? Nationwide register-based study on first births in Finland in 2005–2014. Acta Obstet Gynecol Scand. 2016;95:1368–75.10.1111/aogs.13020Search in Google Scholar PubMed
[12] Dietl A, Cupisti S, Beckmann MW, Schwab M, Zollner U. Pregnancy and Obstetrical Outcomes in Women Over 40 Years of Age. Geburtshilfe Frauenheilkd. 2015;75: 827–32.10.1055/s-0035-1546109Search in Google Scholar PubMed PubMed Central
©2018 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- Editorial
- Corner of Academy
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- Original articles – Obstetrics
- Is forty the new thirty? Population based study of advanced maternal age
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- Epidural analgesia at trial of labor after cesarean (TOLAC): a significant adjunct to successful vaginal birth after cesarean (VBAC)
- Postpartum infection in relation to maternal characteristics, obstetric interventions and complications
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- Five years’ experience in an anesthesiology antenatal clinic for high-risk patients
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- Induction of labor in patients with an unfavorable cervix after a cesarean using an osmotic dilator versus vaginal prostaglandin
- The misoprostol vaginal insert compared with oral misoprostol for labor induction in term pregnancies: a pair-matched case-control study
- Adiponectin concentration in mid-trimester amniotic fluid varies with the α-amylase level and maternal and neonatal outcomes
- Placental examination in nonmacerated stillbirth versus neonatal mortality
- Neurodevelopmental outcome at the age of 4 years according to the planned mode of delivery in term breech presentation: a nationwide, population-based record linkage study
- An observation of umbilical coiling index in a low risk population in Nigeria
Articles in the same Issue
- Frontmatter
- Editorial
- Editorial
- Corner of Academy
- Peripartum cardiomyopathy – from pathogenesis to treatment
- Original articles – Obstetrics
- Is forty the new thirty? Population based study of advanced maternal age
- The laboratory control of anticoagulant thromboprophylaxis during the early postpartum period after cesarean delivery
- Epidural analgesia at trial of labor after cesarean (TOLAC): a significant adjunct to successful vaginal birth after cesarean (VBAC)
- Postpartum infection in relation to maternal characteristics, obstetric interventions and complications
- A technological advance for 21st century obstetricians: the electronically-controlled vacuum extractor
- Five years’ experience in an anesthesiology antenatal clinic for high-risk patients
- Clinical analyses of 383 cases with maternal cardiac diseases
- Induction of labor in patients with an unfavorable cervix after a cesarean using an osmotic dilator versus vaginal prostaglandin
- The misoprostol vaginal insert compared with oral misoprostol for labor induction in term pregnancies: a pair-matched case-control study
- Adiponectin concentration in mid-trimester amniotic fluid varies with the α-amylase level and maternal and neonatal outcomes
- Placental examination in nonmacerated stillbirth versus neonatal mortality
- Neurodevelopmental outcome at the age of 4 years according to the planned mode of delivery in term breech presentation: a nationwide, population-based record linkage study
- An observation of umbilical coiling index in a low risk population in Nigeria
