Dopamine treatment does not need speed recovery of newborns from transient tachypnea

Nilufer Guzoglu; Nurdan Uras; Hatice T. Aksoy; Zeynep Eras; Serife S. Oguz; Ugur Dilmen

doi:10.1515/jpm-2015-0077

Article

Dopamine treatment does not need speed recovery of newborns from transient tachypnea

Nilufer Guzoglu , Nurdan Uras , Hatice T. Aksoy , Zeynep Eras , Serife S. Oguz and Ugur Dilmen

Published/Copyright: July 22, 2015

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From the journal Journal of Perinatal Medicine Volume 44 Issue 4

Abstract

Objective: Transient tachypnea of the newborn (TTN) results from inadequate neonatal lung fluid clearance. Low-dose dopamine induces natriuresis in the kidneys and it has been assumed that, at this low dosage, dopamine increases renal perfusion in critically ill patients. Medium doses have positive inotropic and chronotropic effects via increased β-receptor activation. Recent studies have demonstrated that dopamine stimulates the clearance of pulmonary edema. Furthermore, β-adrenergic agonists regulate Na⁺ channels and Na-K-ATPase activity in the pulmonary epithelium. This study investigated the effect of dopamine at different dosages on TTN treatment.

Methods: A prospective controlled study examined 60 infants with TTN older than 34 weeks of gestation who required at least 24 h of O₂ and nasal continuous positive airway pressure (nCPAP) treatment. The infants were randomized into three groups of 20: controls, infants treated with low-dose dopamine (3 μg/kg/min), and infants treated with a medium dose (5 μg/kg/min). The control and study groups were compared in terms of the requirement for mechanical ventilation, and the durations of nCPAP, oxygen requirement, and hospitalization.

Results: The requirement for mechanical ventilation, and durations of nCPAP, oxygen requirement, and hospitalization did not differ significantly among the three groups (P=0.54, 0.16 and 0.11, respectively).

Conclusion: Dopamine treatment in low-moderate doses does not improve the outcome in TTN. Thus, further studies in this area are needed.

Keywords: Dopamine; newborn; transient tachypnea

Corresponding author: Nilufer Guzoglu, MD, Erenler Mah. Asude Sehir Sitesi, B 11 Yahsihan, Kirikkale, Turkey, Tel.: +0090 5059219912, Fax: +0312 3124931, E-mail: nguzoglu@gmail.com; and Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey

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The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2015-2-25

Accepted: 2015-6-17

Published Online: 2015-7-22

Published in Print: 2016-5-1

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https://doi.org/10.1515/jpm-2015-0077

Keywords for this article

Dopamine; newborn; transient tachypnea