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Effect of maternal vitamin A deficiency during pregnancy on neonatal kidney size

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Veröffentlicht/Copyright: 5. September 2012
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 41 Heft 2

Abstract

Background and aims: In animal studies, vitamin A deficiency (VAD) during pregnancy has been shown to be associated with a decrease in nephron number and kidney weight of the offspring. At present, it is unclear whether these observations are pertinent to humans. Thus, this study was performed to assess the vitamin A status of a cohort of Egyptian pregnant women and their newborns and to determine the potential effect of maternal VAD during pregnancy on the neonatal kidney size.

Methods: The maternal and cord blood samples were collected for the measurement of serum retinol concentration. Within the first 3 days after delivery, an abdominal ultrasound was performed in all newborns to determine the renal dimensions and volume.

Results: Sixteen (20%) mothers had VAD. The newborns delivered to VAD mothers had significantly lower mean values of cord retinol concentrations and dimensions of both kidneys than the newborns delivered to mothers with vitamin A sufficiency. The maternal serum retinol concentrations were positively correlated with the cord retinol concentrations, the dimensions of both kidneys, and the combined renal volume of their respective newborns.

Conclusion: Maternal VAD during pregnancy may decrease renal size in the infant at birth. The functional implications of this effect warrant further study.

Keywords: Pregnancy; renal size; serum retinol; vitamin A
Corresponding author: Ahmad M. Hamdy, Assistant Professor of Pediatrics, Consultant of Nutrition and Pediatric Gastroenterology and Endoscopy, Faculty of Medicine, Pediatrics Department, Ain Shams University, 66 Rabeaa Al-estesmary Building, Nsr City, Cairo, Egypt, Tel.: +2-02-22704206/Mobile: +2-01-22421384
Received: 2012-2-6
Revised: 2012-2-6
Accepted: 2012-8-16
Published Online: 2012-09-05
Published in Print: 2013-03-01

©2013 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/jpm-2012-0026
Schlagwörter für diesen Artikel
Pregnancy; renal size; serum retinol; vitamin A

Artikel in diesem Heft

  1. Masthead
  2. Masthead
  3. Recommendation and Guidelines for Perinatal Practice
  4. Presence of human milk bank is associated with elevated rate of exclusive breastfeeding in VLBW infants
  5. Reviews
  6. Bariatric surgery and pregnancy: the magical solution?
  7. Placenta accreta and the risk of adverse maternal and neonatal outcomes
  8. Original Articles - Obstetrics
  9. Correlation between an absence of cervical gland area on transvaginal sonography and cervical mucus hyaluronic acid levels in women with threatened preterm delivery
  10. Adult separation anxiety during pregnancy and its relationship to depression and anxiety
  11. Value of Doppler sonography near term: can umbilical and uterine artery indices in low-risk pregnancies predict perinatal outcome?
  12. Induction of labor after a prior cesarean delivery: lessons from a population-based study
  13. Clinical evaluation of soluble intercellular adhesion molecule-1 and insulin like growth factor-binding protein-1-based rapid immunoassays for the diagnosis of prelabor rupture of membranes
  14. Original Articles - Fetus
  15. The clinical value of KANET in studying fetal neurobehavior in normal and at-risk pregnancies
  16. Original Articles - Newborn
  17. Effect of maternal vitamin A deficiency during pregnancy on neonatal kidney size
  18. Polymorphism 1936A>G in the AKAP10 gene (encoding A-kinase-anchoring protein 10) is associated with higher cholesterol cord blood concentration in Polish full-term newborns
  19. Defining hypoxic ischemic encephalopathy in newborn infants: benchmarking in a South African population
  20. Comparison of left ventricular cardiac dimensions between small and appropriate for gestational age preterm infants below 30 weeks of gestation
  21. Letter to the Editor
  22. Vegan carriage of group B streptococcus: a questionnaire study utilising social media
  23. Book Review
  24. I hear a song in my head. A memoir in stories of love, fear, doctoring and flight
  25. Congress Calendar
  26. Congress Calendar
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