Startseite Simultaneous onset and similar course of type 1 diabetes mellitus in monozygotic twins (a 4-year follow-up)
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Simultaneous onset and similar course of type 1 diabetes mellitus in monozygotic twins (a 4-year follow-up)

  • Annalisa Blasetti EMAIL logo , Rosa Maria Chiuri , Anna Maria Tocco , Giovanna Di Sabatino , Francesco Chiarelli und Alberto Verrotti
Veröffentlicht/Copyright: 21. Dezember 2011

Abstract

We report a rare case of monozygotic (MZ) twins who developed simultaneous onset of type 1 diabetes mellitus (T1DM). Laboratory finding showed similar values of blood sugar, pH, glycosylated hemoglobin, and C-peptide. Urinary sugar and ketones were detected in both. Endocrine and immunological assessment showed similar results. No evidence (clinical or serological) of recent viral or bacterial infection was found. In the 4 years of follow-up, the twins also showed a similar course of disease. Concordance rates for T1DM are high in MZ twins; nevertheless, a simultaneous onset and a similar course of disease are unusual, as well as the HLA allelic variants of our patients. This extraordinary concordance in a pair of MZ twins could be the consequence of a greater environmental similarity or the role of genetic factors other than HLA genes in our twins.


Corresponding author: Annalisa Blasetti, MD, PhD, Department of Pediatrics, University of Chieti, Italy, Via dei Vestini 5, 66100 Chieti, Italy Phone: +39 0871/358021-358015, Fax: +39 0871/574831

Received: 2011-8-5
Accepted: 2011-10-24
Published Online: 2011-12-21
Published in Print: 2012-06-01

©2012 by Walter de Gruyter Berlin Boston

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Heruntergeladen am 9.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/jpem.2011.376/pdf
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